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:: Volume 17, Issue 1 (10 2008) ::
aud 2008, 17(1): 45-52 Back to browse issues page
Effects of caffeine on auditory brainstem response
Saleheh Soleimanian1 , Saeed Farahani * 2, Mansoureh Adel Ghahraman2 , Abbas Kebriaiezadeh3 , Soghrat Faghihzadeh4
1- M.Sc. in Audiology, Faculty of Rehabilitation, Tehran University of Medical Sciences, Iran
2- Audiology Department, Faculty of Rehabilitation, Tehran University of Medical Scineces, Iran
3- Toxicology and Pharmacology Department, Faculty of Pharmacy, Tehran University of Medical Scineces,
4- Biostatistic Department, Tarbiat Modarres University, Iran
Abstract:   (9676 Views)

Background and Aim: Blocking of the adenosine receptor in central nervous system by caffeine can lead to increasing the level of neurotransmitters like glutamate. As the adenosine receptors are present in almost all brain areas like central auditory pathway, it seems caffeine can change conduction in this way. The purpose of this study was to evaluate the effects of caffeine on latency and amplitude of auditory brainstem response(ABR).
Materials and Methods: In this clinical trial study 43 normal 18-25 years old male students were participated. The subjects consumed 0, 2 and 3 mg/kg BW caffeine in three different sessions. Auditory brainstem responses were recorded before and 30 minute after caffeine consumption. The results were analyzed by Friedman and Wilcoxone test to assess the effects of caffeine on auditory brainstem response.
Results: Compared to control group the latencies of waves III,V and I-V interpeak interval of the cases decreased significantly after 2 and 3mg/kg BW caffeine consumption. Wave I latency significantly decreased after 3mg/kg BW caffeine consumption(p<0.01).
Conclusion: Increasing of the glutamate level resulted from the adenosine receptor blocking brings about changes in conduction in the central auditory pathway.

Keywords: caffeine, auditory brainstem response, interpeak latency, absolute latency, amplitude
Full-Text [PDF 134 kb]   (4182 Downloads)    
Type of Study: Research |
Received: 2008/02/17 | Accepted: 2008/09/7 | Published: 2013/10/9
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Creative Commons License This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
Volume 17, Issue 1 (10 2008) Back to browse issues page
شنوایی شناسی - دانشگاه علوم پزشکی تهران Bimonthly Audiology - Tehran University of Medical Sciences
Creative Commons Attribution-NonCommercial 3.0

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