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Showing 3 results for Amplitude
Saleheh Soleimanian, Saeed Farahani, Mansoureh Adel Ghahraman, Abbas Kebriaiezadeh, Soghrat Faghihzadeh,
Volume 17, Issue 1 (11-2008)
Abstract
Background and Aim: Blocking of the adenosine receptor in central nervous system by caffeine can lead to increasing the level of neurotransmitters like glutamate. As the adenosine receptors are present in almost all brain areas like central auditory pathway, it seems caffeine can change conduction in this way. The purpose of this study was to evaluate the effects of caffeine on latency and amplitude of auditory brainstem response(ABR).
Materials and Methods: In this clinical trial study 43 normal 18-25 years old male students were participated. The subjects consumed 0, 2 and 3 mg/kg BW caffeine in three different sessions. Auditory brainstem responses were recorded before and 30 minute after caffeine consumption. The results were analyzed by Friedman and Wilcoxone test to assess the effects of caffeine on auditory brainstem response.
Results: Compared to control group the latencies of waves III,V and I-V interpeak interval of the cases decreased significantly after 2 and 3mg/kg BW caffeine consumption. Wave I latency significantly decreased after 3mg/kg BW caffeine consumption(p<0.01).
Conclusion: Increasing of the glutamate level resulted from the adenosine receptor blocking brings about changes in conduction in the central auditory pathway.
Ghassem Mohammadkhani, Masumeh Roozbahani, Elahe Zoghi, Jamileh Fatahi, Soghrat Faghihzadeh,
Volume 17, Issue 2 (2-2009)
Abstract
Background and Aim: Tinnitus is an unpleasant sound which can cause some behavioral disorders. According to evidence the origin of tinnitus is not only in peripheral but also in central auditory system. So evaluation of central auditory system function is necessary. In this study Auditory brainstem responses (ABR) were compared in noise induced tinnitus and non-tinnitus control subjects.
Materials and Methods: This cross-sectional, descriptive and analytic study is conducted in 60 cases in two groups including of 30 noise induced tinnitus and 30 non-tinnitus control subjects. ABRs were recorded ipsilateraly and contralateraly and their latencies and amplitudes were analyzed.
Results: Mean interpeak latencies of III-V (p= 0.022), I-V (p=0.033) in ipsilatral electrode array and mean absolute latencies of IV (p=0.015) and V (p=0.048) in contralatral electrode array were significantly increased in noise induced tinnitus group relative to control group.
Conclusion: It can be concluded from that there are some decrease in neural transmission time in brainstem and there are some sign of involvement of medial nuclei in olivery complex in addition to lateral lemniscus.
Parisa Jalilzadeh Afshari, Ghassem Mohamadkhani, Nematollah Rouhbakhsh, Shohreh Jalaie, Ensieh Nasli Esfahani,
Volume 22, Issue 2 (7-2013)
Abstract
Background and Aim: Diabetes mellitus is a common disorder and causes a variety of central nervous system complications such as cognitive deficits. P300 auditory event related potential application is a well established neurophysiological approach in the assessment of cognitive performance. In this study, we compared the results of this application in patients with insulin-dependent (type I) diabetics mellitus and normal individuals.
Methods: In this non-interventional study, auditory P300 was measured in oddball paradigm by using two tone burst stimuli (1000 and 2000 Hz) on 25 patients with type I diabetics mellitus with the mean age of 28.76 years and 25 age-, education- and sex-matched healthy controls with the mean age of 29.68 years. The participants were enrolled by probable and category random sampling style.
Results: The mean P300 latency of the patients with type I diabetes mellitus was significantly prolonged compared with that of normal controls at all electrode sites and in both genders (p<0.001). The mean P300 amplitude of these patients was significantly lower compared with that of normal controls at all electrode sites and in both genders (p<0.001).
Conclusion: Significant prolongation in P300 latency of the patients with type I diabetes mellitus shows that auditory information processing and information categorizing are slower in them. Significant reduction in P300 amplitude of the patients with type I diabetes mellitus demonstrates that working memory in these patients cannot recognize new events and update its context in accordance with them.
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