The major focus of this research is on the differential disruption of language abilities subsequent to brain damages as they relate to site and size of lesion, especially left hemisphere lesions which disrupt the production and processing of "Nouns" vs. "Verbs" as two functionally different lexical categories. Several clinical as well as experimental studies reported on different language have shown that nouns and verbs can be independently disrupted due to brain damage. A prevalent impairment in naming actions (Producing verbs) is reported in non-fluent aphasic patients, with lesions involving left frontal lobe, whereas a selective in naming objects (Producing nouns) has been observed in amnesic patients, with lesions involving the temporal lobe and the temporal lobe and the posterior association aresas. This research is a theoretical and fundamental based on descriptive and analytical method. The aphasic data in this research were obtained by assessing each patient&aposs aphasic symptoms using a standard Persian aphasia test (Paradis, Nilipoure, Paribakht, 1989) as well as post-test analysis of each patient&apos connected descriptive speech. The subjects were selected form among aphasics who referred to speech therapy centers in Tehran during a pe5iod of one year since autumn 1999. The subjects selected in the study were a homogenous group with left hemisphere lesions due to CVA. They were educated adult right handed. Speakers of Persian without any risk factor such as nicotine, alcohol or any addiction and diabetes with no gross depression or anxiety problems or face and oral paralysis and hemiaopsia. The subjects in this study comprised to adults ranging between 33 and 76 years of age. The results indicated that there are significant correlation between: 1) The production of nouns and left hemisphere lesion. 2) The production of verbs and left hemisphere lesion. 3) Brain lesion and language deficits. 4) The site of lesion and language abilities. Although the data are limited and the generalization of the study has certain restrictions, the present data indicate some specific and reliable avidence on the selective impairment of nouns and verbs due to different lesions in the left hemisphere.

Background and Aim: Fluent aphasia and Alzheimer patients have difficulties in perception and naming. Patient with fluent Aphasia and Alzheimer disease, both have difficulty in perception and naming. Their site of lesion is also identical, that is temporoparietal lobe which is damaged in both group. This study investigates the effects of semantic and phonological cues in facilitation of word finding.
Materials and Methods: The study was prescriptive - analytic cross-sectional with 14 patients. The participants were seven fluent aphasia with mean age 48.4 year old and seven Alzheimer patients with mean age 69/71 year old and mean Mini-Mental State Examination (MMSE) 16 score. Those were assessed with Persian Naming Test. The Aphasic patients were selected from Tehran University hospitals and Alzheimer ones were from Rouzbeh hospital and Alzheimer Association of Iran.
Results: Mean semantic and phonological cues in fluent aphasia patients were 2.71 and 12.29, respectively, which significantly different (p=0.01), but those results were 8.29 and 3.43 in Alzheimer patients, that were not significantly different (p>0.05). A main result of this study was significant difference between two cues in both groups.
Conclusion: Two groups of patients use two cues in word finding. The correct responses increase with phonological cue in fluent aphasia but semantic cue has the main role for naming in Alzheimer patients.

Background and Aim: Agrammatism is a phenomenon of neuropsychological relevance which has been recently investigated from conceptual and empirical aspects. The present study focuses on grammatical deficit in agrammatic aphasia. We evaluated the impairment of correct use of tenses of Persian verbs in agrammatic Broca&aposs aphasia.
Methods: Eight patients (mean age 57 years) participated in this descriptive - analytic study. They were classified as agrammatic Broca&aposs aphasia according to the Persian aphasia test, their CT Scan and MRI reports and other inclusion criteria. All patients but one were monolingual native speakers of Persian (Farsi). The other individual was bilingual whose dominant language was Persian. All subjects had a left unilateral brain lesion for at least one year after the onset of brain damage. The written sentence completion and picture sentence completion tests were designed and performed.
Results: Results do not indicate significant difference between Past Tenses of verb however, comparison of means showed best scores in Simple Past, Past Continuous, Present Perfect and Past Perfect, respectively. A main result of this study was significant difference between the mean of responses to Past Tense in comparison with Present Tense and Future (p=0.02).
Conclusion: Use of tense is impaired in agrammatic Broca&aposs aphasia in Persian. Our findings point out that use of Past Tense is impaired significantly more than the other tenses of verb.

Background and Aim: One of the common problems in many types of aphasia syndromes is word retrieval and/or production difficulty. So, designing a valid test that can examine this problem based on related processes and influencing factors is important. Picture confrontation naming is a typical method for assessing and treatment of word retrieval impairments. The aim of this study was determining the validity and reliability of oral picture-naming test in assessing word retrieval ability of aphasic adults.
Methods: Content and face validity of the test, that contains the line drawings of 115 Persian nouns, were assessed by speech therapists, graphists and painters. Then, the test was administered on 10 aphasics and 30 age-, gender- and education-matched normal subjects in two steps. Construct validity and internal consistency of test were investigated. External consistency was analyzed by test-retest method.
Results: The content and face validity of all items were more than 90 and 85 percents, respectively. There was a statistically significant difference between the mean scores of patients and normal subjects (p<0.001). The internal consistency of 0.98 was determined for the test. The intra-class correlation coefficient of this test was 0.98.
Conclusions: The oral picture-naming test had good content, face and construct validity. Also, internal and external consistencies were high. So, this test is a valid instrument for assessing naming ability of aphasic patients by a variety and big set of picture.

Background and Aim: Aphasia, after stroke in the left hemisphere, is a common symptom. These patients often experience incomplete recovery despite intensive speech therapy. Direct electrical stimulation of the brain is a technique to stimulate the brain in patients with neurological and psychiatric diseases. The aim of this study was to investigate the effects of this stimulation on recovery of naming ability, working memory, and aphasia quotient and the lasting duration in patients with non-fluent aphasia.

Methods: In this interventional study, 10 patients with after-stroke non-fluent aphasia were enrolled. Their aphasia quotient, working memory and naming ability scores were compared before and after sham and real treatments and two months after the real treatment. 10 sessions of 20-minutes sham electrical stimulation and 10 sessions of 20-minutes anodic and cathodic stimulation (2 mA) at the dorsal lateral perifrontal cortex was done for each patient. Data were analyzed using repeated-measures ANOVA and Friedman nonparametric tests.

Results: The ability of naming and working memory scores were increased significantly after treatment and two months after it compared with before study and after sham treatment (p<0.05 for all). There was no significant improvement in aphasia quotient.

Conclusion: The transcranial direct current stimulation can sustain improvement in naming function and working memory in patients with non-fluent aphasia. It can be used in the rehabilitation program of these patients.