Iranian Journal of Diabetes and Lipid Disorders
مجله دیابت و متابولیسم ایران
ijdld
Medical Sciences
http://ijdld.tums.ac.ir
1
admin
2345-4008
2345-4016
000
000
000
000
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fa
jalali
1402
2
1
gregorian
2023
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23
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online
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fulltext
fa
تأثیر هشت هفته تمرین تناوبی شدید (HIIT) بر آسپروزین، پروفایل لیپیدی و مقاومت به انسولین رتهای نر مدل دیابت نوع دو
Effect of Eight Weeks High Intensity Interval Training (HIIT) on Asprosin, Lipid Profile and Insulin Resistance in Type 2 Diabetic Male Rats
تخصصي
Special
پژوهشي
Research
<span style="font-size:11pt"><span style="line-height:95%"><span style="text-autospace:none"><span style="direction:rtl"><span style="unicode-bidi:embed"><span calibri="" style="font-family:"><b><span lang="AR-SA" style="font-size:12.0pt"><span style="line-height:95%"><span b="" lotus="" style="font-family:">مقدمه:</span></span></span></b><span lang="AR-SA" style="font-size:12.0pt"><span style="line-height:95%"><span b="" lotus="" style="font-family:"> ترشح آدیپوکاینها از مخازن بافت چربی نقش کلیدی در تنظیم سوختوساز متابولیک و چندین فرآیند فیزیولوژیکی دیگر از جمله دیابت، چاقی و بیماریهای قلبی-عروقی را داراست. در این مطالعه اثر هشت هفته تمرین تناوبی شدید</span></span></span> <span lang="AR-SA" style="font-size:12.0pt"><span style="line-height:95%"><span b="" lotus="" style="font-family:">(</span></span></span><span dir="LTR" style="font-size:10.0pt"><span style="line-height:95%"><span new="" roman="" style="font-family:" times="">HIIT</span></span></span><span lang="AR-SA" style="font-size:12.0pt"><span style="line-height:95%"><span b="" lotus="" style="font-family:">) بر آسپروزین، پروفایل لیپیدی و مقاومت به انسولین رتهای نر مدل دیابت نوع دو بررسی شد.</span></span></span></span></span></span></span></span></span><br>
<span style="font-size:11pt"><span style="line-height:95%"><span style="text-autospace:none"><span style="direction:rtl"><span style="unicode-bidi:embed"><span calibri="" style="font-family:"><b><span lang="AR-SA" style="font-size:12.0pt"><span style="line-height:95%"><span b="" lotus="" style="font-family:">روشها:</span></span></span></b><span lang="AR-SA" style="font-size:12.0pt"><span style="line-height:95%"><span b="" lotus="" style="font-family:"> تعداد 24 سر رت نر اسپراگداولی بهطور تصادفی به چهار گروه مساوی سالم (</span></span></span><span dir="LTR" style="font-size:10.0pt"><span style="line-height:95%"><span new="" roman="" style="font-family:" times="">C</span></span></span><span lang="AR-SA" style="font-size:12.0pt"><span style="line-height:95%"><span b="" lotus="" style="font-family:">)، سالم تمرین</span></span></span> <span lang="AR-SA" style="font-size:12.0pt"><span style="line-height:95%"><span b="" lotus="" style="font-family:">(</span></span></span><span dir="LTR" style="font-size:10.0pt"><span style="line-height:95%"><span new="" roman="" style="font-family:" times="">C+T</span></span></span><span lang="AR-SA" style="font-size:12.0pt"><span style="line-height:95%"><span b="" lotus="" style="font-family:">)، دیابت (</span></span></span><span dir="LTR" style="font-size:10.0pt"><span style="line-height:95%"><span new="" roman="" style="font-family:" times="">D</span></span></span><span lang="AR-SA" style="font-size:12.0pt"><span style="line-height:95%"><span b="" lotus="" style="font-family:">) و دیابت تمرین (</span></span></span><span dir="LTR" style="font-size:10.0pt"><span style="line-height:95%"><span new="" roman="" style="font-family:" times="">D+T</span></span></span><span lang="AR-SA" style="font-size:12.0pt"><span style="line-height:95%"><span b="" lotus="" style="font-family:">) تقسیم شدند. دیابت با روش ترکیبی رژیم پُرچرب و تزریق استرپتوزوتوسین با دوز کم القا شد. گروه تمرین به مدت هشت هفته برنامهی </span></span></span><span dir="LTR" style="font-size:10.0pt"><span style="line-height:95%"><span new="" roman="" style="font-family:" times="">HIIT</span></span></span><span lang="AR-SA" style="font-size:12.0pt"><span style="line-height:95%"><span b="" lotus="" style="font-family:"> را روی تردمیل انجام دادند. دادهها با استفاده از آزمون آماری </span></span></span><span dir="LTR" style="font-size:10.0pt"><span style="line-height:95%"><span new="" roman="" style="font-family:" times="">ANOVA</span></span></span><span style="font-size:12.0pt"><span style="line-height:95%"><span b="" lotus="" style="font-family:"> یک</span></span></span><span dir="LTR" style="font-size:12.0pt"><span style="line-height:95%"></span></span><span lang="AR-SA" style="font-size:12.0pt"><span style="line-height:95%"><span b="" lotus="" style="font-family:">طرفه و آزمون بونفرونی و در سطح معنیداری <span style="border:none windowtext 1.0pt; background:white; padding:0cm"><span style="color:black">05/0</span></span></span></span></span><span dir="LTR" style="border:none windowtext 1.0pt; font-size:10.0pt; padding:0cm"><span style="background:white"><span style="line-height:95%"><span new="" roman="" style="font-family:" times=""><span style="color:black">P</span></span></span></span></span><span dir="LTR" style="border:none windowtext 1.0pt; font-size:12.0pt; padding:0cm"><span style="background:white"><span style="line-height:95%"><span new="" roman="" style="font-family:" times=""><span style="color:black"><</span></span></span></span></span> <span lang="AR-SA" style="font-size:12.0pt"><span style="line-height:95%"><span b="" lotus="" style="font-family:">تحلیل شد.</span></span></span></span></span></span></span></span></span><br>
<span style="font-size:11pt"><span style="line-height:95%"><span style="direction:rtl"><span style="unicode-bidi:embed"><span calibri="" style="font-family:"><b><span lang="AR-SA" style="font-size:12.0pt"><span style="line-height:95%"><span b="" lotus="" style="font-family:">یافته</span></span></span></b><b><span dir="LTR" style="font-size:12.0pt"><span style="line-height:95%"><span new="" roman="" style="font-family:" times=""></span></span></span></b><b><span lang="AR-SA" style="font-size:12.0pt"><span style="line-height:95%"><span b="" lotus="" style="font-family:">ها:</span></span></span></b><span lang="AR-SA" style="font-size:12.0pt"><span style="line-height:95%"><span b="" lotus="" style="font-family:"> <span style="border:none windowtext 1.0pt; background:white; padding:0cm"><span style="color:black">نتایج نشان داد که القای دیابت باعث افزایش آسپروزین سرم شد</span></span>(000</span></span></span><span lang="FA" style="font-size:12.0pt"><span style="line-height:95%"><span b="" lotus="" style="font-family:">۱</span></span></span><span lang="AR-SA" style="font-size:12.0pt"><span style="line-height:95%"><span b="" lotus="" style="font-family:">/0=</span></span></span><span dir="LTR" style="font-size:10.0pt"><span style="line-height:95%"><span new="" roman="" style="font-family:" times="">P</span></span></span><span lang="AR-SA" style="font-size:12.0pt"><span style="line-height:95%"><span b="" lotus="" style="font-family:">)، آسپروزین پلاسما در گروه <span style="border:none windowtext 1.0pt; background:white; padding:0cm"><span style="color:black">سالم تمرین</span></span> نسبت به گروه سالم (03/0=</span></span></span><span dir="LTR" style="font-size:10.0pt"><span style="line-height:95%"><span new="" roman="" style="font-family:" times="">P</span></span></span><span lang="AR-SA" style="font-size:12.0pt"><span style="line-height:95%"><span b="" lotus="" style="font-family:">)</span></span></span> <span lang="AR-SA" style="font-size:12.0pt"><span style="line-height:95%"><span b="" lotus="" style="font-family:">و دیابت نسبت به دیابت تمرین (0</span></span></span><span lang="FA" style="font-size:12.0pt"><span style="line-height:95%"><span b="" lotus="" style="font-family:">4</span></span></span><span lang="AR-SA" style="font-size:12.0pt"><span style="line-height:95%"><span b="" lotus="" style="font-family:">/0=</span></span></span><span dir="LTR" style="font-size:10.0pt"><span style="line-height:95%"><span new="" roman="" style="font-family:" times="">P</span></span></span><span lang="AR-SA" style="font-size:12.0pt"><span style="line-height:95%"><span b="" lotus="" style="font-family:">) کاهش یافت. بین گروه سالم و <span style="border:none windowtext 1.0pt; background:white; padding:0cm"><span style="color:black">سالم</span></span></span></span></span> <span lang="AR-SA" style="border:none windowtext 1.0pt; font-size:12.0pt; padding:0cm"><span style="background:white"><span style="line-height:95%"><span b="" lotus="" style="font-family:"><span style="color:black">تمرین</span></span></span></span></span><span lang="AR-SA" style="font-size:12.0pt"><span style="line-height:95%"><span b="" lotus="" style="font-family:"> از نظر </span></span></span><span dir="LTR" style="font-size:10.0pt"><span style="line-height:95%"><span new="" roman="" style="font-family:" times="">HOMA-IR</span></span></span> <span lang="AR-SA" style="font-size:12.0pt"><span style="line-height:95%"><span b="" lotus="" style="font-family:">تفاوت معنادار وجود نداشت (9/0= </span></span></span><span dir="LTR" style="font-size:10.0pt"><span style="line-height:95%"><span new="" roman="" style="font-family:" times="">P</span></span></span><span lang="AR-SA" style="font-size:12.0pt"><span style="line-height:95%"><span b="" lotus="" style="font-family:">)،</span></span></span> <span lang="AR-SA" style="font-size:12.0pt"><span style="line-height:95%"><span b="" lotus="" style="font-family:">اما در گروه <span style="border:none windowtext 1.0pt; background:white; padding:0cm"><span style="color:black">دیابت تمرین </span></span>نسبت به دیابت کاهش یافت (0</span></span></span><span lang="FA" style="font-size:12.0pt"><span style="line-height:95%"><span b="" lotus="" style="font-family:">001</span></span></span><span lang="AR-SA" style="font-size:12.0pt"><span style="line-height:95%"><span b="" lotus="" style="font-family:">/0=</span></span></span><span dir="LTR" style="font-size:10.0pt"><span style="line-height:95%"><span new="" roman="" style="font-family:" times="">P</span></span></span><span lang="AR-SA" style="font-size:12.0pt"><span style="line-height:95%"><span b="" lotus="" style="font-family:">). </span></span></span><span lang="FA" style="font-size:12.0pt"><span style="line-height:95%"><span b="" lotus="" style="font-family:">در</span></span></span><span lang="AR-SA" style="font-size:12.0pt"><span style="line-height:95%"><span b="" lotus="" style="font-family:">گروه <span style="border:none windowtext 1.0pt; background:white; padding:0cm"><span style="color:black">دیابت تمرین </span></span>نسبت به گروه دیابت میانگین </span></span></span><span dir="LTR" style="font-size:10.0pt"><span style="line-height:95%"><span new="" roman="" style="font-family:" times="">HDL</span></span></span><span lang="AR-SA" style="font-size:12.0pt"><span style="line-height:95%"><span b="" lotus="" style="font-family:"> افزایش (00</span></span></span><span lang="FA" style="font-size:12.0pt"><span style="line-height:95%"><span b="" lotus="" style="font-family:">01</span></span></span><span lang="AR-SA" style="font-size:12.0pt"><span style="line-height:95%"><span b="" lotus="" style="font-family:">/0=</span></span></span><span dir="LTR" style="font-size:12.0pt"><span style="line-height:95%"><span new="" roman="" style="font-family:" times="">p</span></span></span><span lang="AR-SA" style="font-size:12.0pt"><span style="line-height:95%"><span b="" lotus="" style="font-family:">)</span></span></span> <span lang="AR-SA" style="font-size:12.0pt"><span style="line-height:95%"><span b="" lotus="" style="font-family:">و </span></span></span><span dir="LTR" style="font-size:10.0pt"><span style="line-height:95%"><span new="" roman="" style="font-family:" times="">TG</span></span></span><span lang="AR-SA" style="font-size:12.0pt"><span style="line-height:95%"><span b="" lotus="" style="font-family:">،</span></span></span> <span dir="LTR" style="font-size:10.0pt"><span style="line-height:95%"><span new="" roman="" style="font-family:" times="">LDL</span></span></span><span lang="AR-SA" style="font-size:12.0pt"><span style="line-height:95%"><span b="" lotus="" style="font-family:"> کاهش یافت (0</span></span></span><span lang="FA" style="font-size:12.0pt"><span style="line-height:95%"><span b="" lotus="" style="font-family:">01</span></span></span><span lang="AR-SA" style="font-size:12.0pt"><span style="line-height:95%"><span b="" lotus="" style="font-family:">/0=</span></span></span><span dir="LTR" style="font-size:10.0pt"><span style="line-height:95%"><span new="" roman="" style="font-family:" times="">P</span></span></span><span lang="AR-SA" style="font-size:12.0pt"><span style="line-height:95%"><span b="" lotus="" style="font-family:">). در گروه سالم تمرین نسبت به <span style="border:none windowtext 1.0pt; background:white; padding:0cm"><span style="color:black">سالم</span></span> میانگین </span></span></span> <span dir="LTR" style="font-size:10.0pt"><span style="line-height:95%"><span new="" roman="" style="font-family:" times="">HDL</span></span></span><span lang="AR-SA" style="font-size:12.0pt"><span style="line-height:95%"><span b="" lotus="" style="font-family:">افزایش</span></span></span> <span lang="AR-SA" style="font-size:12.0pt"><span style="line-height:95%"><span b="" lotus="" style="font-family:">(</span></span></span><span lang="FA" style="font-size:12.0pt"><span style="line-height:95%"><span b="" lotus="" style="font-family:">01</span></span></span><span lang="AR-SA" style="font-size:12.0pt"><span style="line-height:95%"><span b="" lotus="" style="font-family:">/0=</span></span></span><span dir="LTR" style="font-size:10.0pt"><span style="line-height:95%"><span new="" roman="" style="font-family:" times="">P</span></span></span><span lang="AR-SA" style="font-size:12.0pt"><span style="line-height:95%"><span b="" lotus="" style="font-family:">) اما </span></span></span><span dir="LTR" style="font-size:10.0pt"><span style="line-height:95%"><span new="" roman="" style="font-family:" times="">TG</span></span></span><span lang="AR-SA" style="font-size:12.0pt"><span style="line-height:95%"><span b="" lotus="" style="font-family:">،</span></span></span> <span dir="LTR" style="font-size:10.0pt"><span style="line-height:95%"><span new="" roman="" style="font-family:" times="">LDL</span></span></span><span lang="AR-SA" style="font-size:12.0pt"><span style="line-height:95%"><span b="" lotus="" style="font-family:"> تفاوت معنادار نداشت.</span></span></span></span></span></span></span></span><br>
<span style="font-size:11pt"><span style="line-height:95%"><span style="direction:rtl"><span style="unicode-bidi:embed"><span calibri="" style="font-family:"><b><span lang="AR-SA" style="font-size:12.0pt"><span style="line-height:95%"><span b="" lotus="" style="font-family:">نتیجهگیری:</span></span></span></b><span lang="AR-SA" style="font-size:12.0pt"><span style="line-height:95%"><span b="" lotus="" style="font-family:"> غلظت آسپروسین در رتهای مبتلا به دیابت دو افزایش مییابد و </span></span></span><span dir="LTR" style="font-size:10.0pt"><span style="line-height:95%"><span new="" roman="" style="font-family:" times="">HIIT</span></span></span><span lang="AR-SA" style="font-size:12.0pt"><span style="line-height:95%"><span b="" lotus="" style="font-family:"> میتواند با کاهش آسپروزین، شاخص مقاومت به انسولین و بهبود پروفایل لیپیدی عوارض ناشی از دیابت را کاهش دهد.</span></span></span></span></span></span></span></span>
<span style="font-size:11pt"><span style="line-height:92%"><span calibri="" style="font-family:"><b><span new="" roman="" style="font-family:" times="">Background:</span></b><span new="" roman="" style="font-family:" times=""> The release of adipokines from adipose tissue depots plays a key role in regulating metabolic homeostasis and several other physiological processes, including diabetes, obesity, and vascular diseases. This study investigated the effect of eight weeks of high intensity interval training (HIIT) on asprosin, lipid profile and insulin resistance in type 2 diabetic male rats.</span></span></span></span><br>
<span style="font-size:11pt"><span style="line-height:92%"><span calibri="" style="font-family:"><b><span new="" roman="" style="font-family:" times="">Methods:</span></b><span new="" roman="" style="font-family:" times=""> 24 male Sprague Dawley rats were randomly divided into four equal groups: control (C), control traning (C+T), diabet (D) and diabet traning (D+T). Diabetes was induced by the combined method of high fat diet and low dose strepotozocin injection. The traning group performed the HIIT program on the treadmill for eight weeks. Data were analyzed using one-way ANOVA and bonferroni post hoc test at a significance level of P<0.05.</span></span></span></span><br>
<span style="font-size:11pt"><span style="line-height:92%"><span calibri="" style="font-family:"><b><span new="" roman="" style="font-family:" times="">Results:</span></b><span new="" roman="" style="font-family:" times=""> The results showed increased plasma asprosin in D group compared to C (P=0.0001) and decreased in C+T group compared to C (P=0.03) and D+T group compared to D (P=0.04). There was no significant difference in HOMA-IR between the C and C+T group (P=0.9) but decreased in D+T compared to D (P=0.0001). HDL increased in D+T group compared to the D (P=0.0001) and decreased TG and LDL (P=0.001). There was no significant difference between TG and LDL in the C group compared to the C+T, but HDL increased in C+T (P=0.01).</span></span></span></span><br>
<span style="font-size:11pt"><span style="line-height:92%"><span calibri="" style="font-family:"><b><span new="" roman="" style="font-family:" times="">Conclusion:</span></b><span new="" roman="" style="font-family:" times=""> Plasma asprosin increases in rats with type 2 diabetes and HIIT can reduce the complications of diabetes by improved lipid profile and reduce asprosin and insulin resistance.</span></span></span></span><br>
<span style="font-size:11pt"><span style="line-height:92%"><span calibri="" style="font-family:"><b><span style="font-family:"Times New Roman",serif"></span></b></span></span></span>
تمرینات تناوبی با شدت بالا, آسپروزین, مقاومت به انسولین, پروفایل لیپیدی, دیابت نوع دو
High-Intensity Interval Training, Asprosin, Insulin Resistance, Lipid Profile, Type 2 Diabetes
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http://ijdld.tums.ac.ir/browse.php?a_code=A-10-1899-1&slc_lang=fa&sid=1
Mahboobeh
Rangraz tabatabaei
محبوبه
رنگرز طباطبایی
mah.r.taba@gmail.com