Iranian Journal of Health and Environment
سلامت و محیط زیست
ijhe
Medical Sciences
http://ijhe.tums.ac.ir
1
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2008-2029
2008-3718
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2023
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ارتباط بین مواجهه با کادمیم و خطر رخداد سرطان پستان :مطالعه مروری نظاممند و متاآنالیز
Relationship between cadmium exposure and breast cancer risk: a systematic review and meta-analysis
عمومى
General
مرور ساختاریافته
Systematic Review
<div style="text-align: justify;"><span style="font-size:11pt"><span style="line-height:115%"><span style="tab-stops:68.55pt 182.65pt"><span style="direction:rtl"><span style="unicode-bidi:embed"><span calibri="" style="font-family:"><b><span lang="FA" style="font-size:12.0pt"><span style="line-height:115%"><span b="" lotus="" style="font-family:">زمینه و هدف: </span></span></span></b><span lang="FA" style="font-size:12.0pt"><span style="line-height:115%"><span b="" lotus="" style="font-family:">سرطان پستان شایعترین بدخیمی در زنان در سراسر جهان است</span></span></span><span lang="AR-SA" style="font-size:12.0pt"><span style="line-height:115%"><span b="" lotus="" style="font-family:">.</span></span></span><span lang="FA" style="font-size:12.0pt"><span style="line-height:115%"><span b="" lotus="" style="font-family:"> کادمیم یکی از فلزهای سنگین بسیار پایدار و سمی است که قرارگرفتن در معرض آن ممکن است منجر به افزایش خطر سرطان پستان شود. </span></span></span><span lang="AR-SA" style="font-size:12.0pt"><span style="line-height:115%"><span b="" lotus="" style="font-family:">هدف از این مطالعه، خلاصهسازی کمی شواهد موجود برای ارتباط بین مواجهه با کادمیم و خطر رخداد سرطان پستان با استفاده از روش مرور نظاممند و متاآنالیز است.</span></span></span><b><span lang="FA" style="font-size:12.0pt"><span style="line-height:115%"><span style="font-family:"B Lotus""></span></span></span></b></span></span></span></span></span></span><br>
<b><span dir="RTL" lang="FA" style="font-size:12.0pt"><span style="line-height:107%"><span b="" lotus="" style="font-family:">روش بررسی: </span></span></span></b><span dir="RTL" lang="AR-SA" style="font-size:12.0pt"><span style="line-height:107%"><span b="" lotus="" style="font-family:">در این پژوهش، مطالعات مشاهدهای که تا می ماه سال</span></span></span><span dir="RTL" lang="FA" style="font-size:12.0pt"><span style="line-height:107%"><span b="" lotus="" style="font-family:">۲۰۲۲</span></span></span> <span dir="RTL" lang="AR-SA" style="font-size:12.0pt"><span style="line-height:107%"><span b="" lotus="" style="font-family:">ارتباط بین کادمیم و سرطان پستان را بررسی کرده و در بانکهای اطلاعاتی بینالمللی منتشر شده بودند، جستجو و بازیابی شدند. </span></span><span style="background:white"><span style="line-height:107%"><span b="" lotus="" style="font-family:">برای تعیین هتروژنسیتی</span></span></span></span> <span dir="RTL" lang="FA" style="font-size:12.0pt"><span style="line-height:107%"><span b="" lotus="" style="font-family:">از آزمونهای آماری I<sup>2</sup> و Chi<sup>2</sup>، </span></span></span><span style="font-size:11pt"><span style="line-height:115%"><span style="direction:rtl"><span style="unicode-bidi:embed"><span calibri="" style="font-family:"><span lang="AR-SA" style="font-size:12.0pt"><span style="line-height:115%"><span b="" lotus="" style="font-family:">برای بررسی وجود تورش انتشار از نمودار قیفی و تست بگ و تست ایگر و برای تشخیص ریشه ناهمگنی ها </span></span></span><span lang="FA" style="font-size:12.0pt"><span style="line-height:115%"><span b="" lotus="" style="font-family:">از روش متارگرسیون و آنالیز حساسیت استفاده شد. </span></span></span><b><span lang="FA" style="font-size:12.0pt"><span style="line-height:115%"><span style="font-family:"B Lotus""></span></span></span></b></span></span></span></span></span><br>
<span style="font-size:11pt"><span style="line-height:115%"><span style="direction:rtl"><span style="unicode-bidi:embed"><span calibri="" style="font-family:"><b><span lang="FA" style="font-size:12.0pt"><span style="line-height:115%"><span b="" lotus="" style="font-family:">یافتهها: </span></span></span></b><span lang="AR-SA" style="font-size:12.0pt"><span style="line-height:115%"><span b="" lotus="" style="font-family:">در این مطالعه مشاهده شد که نسبت به گروه پایه، خطر نسبی رخداد سرطان پستان در افراد مواجهه یافته/مواجهه با دوز بالاتر از سطح پایه کادمیم، برابر </span></span></span><span lang="FA" style="font-size:12.0pt"><span style="line-height:115%"><span b="" lotus="" style="font-family:">با (0/001</span></span></span><span lang="FA" style="font-size:12.0pt"><span style="line-height:115%"><span new="" roman="" style="font-family:" times="">≥</span></span></span> <span dir="LTR" style="line-height:115%"><span new="" roman="" style="font-family:" times="">p</span></span><span lang="FA" style="font-size:12.0pt"><span style="line-height:115%"><span b="" lotus="" style="font-family:">؛ 1/14 </span></span></span><span lang="FA" style="font-size:12.0pt"><span style="line-height:115%"><span new="" roman="" style="font-family:" times="">–</span></span></span><span lang="FA" style="font-size:12.0pt"><span style="line-height:115%"><span b="" lotus="" style="font-family:"> 1/06: </span></span></span><span dir="LTR" style="line-height:115%"><span new="" roman="" style="font-family:" times="">CI</span></span><span lang="FA" style="font-size:12.0pt"><span style="line-height:115%"><span b="" lotus="" style="font-family:"> 95 %)1/10 است، بنابراین بین مواجهه با کادمیم و یا دریافت سطح مواجهه بیش از اندازه پایه و ابتلا به سرطان پستان ارتباط آماری معنیداری مشاهده شد. </span></span></span><span lang="AR-SA" style="font-size:12.0pt"><span style="line-height:115%"><span b="" lotus="" style="font-family:">در بررسی احتمال رخداد تورش انتشار، </span></span></span><span lang="FA" style="font-size:12.0pt"><span style="line-height:115%"><span b="" lotus="" style="font-family:">نتیجه</span></span></span> <span lang="AR-SA" style="font-size:12.0pt"><span style="line-height:115%"><span b="" lotus="" style="font-family:">آزمون ایگر برابر با (0/001 </span></span></span><span lang="AR-SA" style="font-size:12.0pt"><span style="line-height:115%"><span new="" roman="" style="font-family:" times="">≤</span></span></span> <span dir="LTR" style="line-height:115%"><span new="" roman="" style="font-family:" times="">p</span></span><span lang="FA" style="font-size:12.0pt"><span style="line-height:115%"><span b="" lotus="" style="font-family:">)</span></span></span> <span lang="AR-SA" style="font-size:12.0pt"><span style="line-height:115%"><span b="" lotus="" style="font-family:">و نتیجه آزمون بگ برابر با (0/099 = </span></span></span><span dir="LTR" style="line-height:115%"><span new="" roman="" style="font-family:" times="">p</span></span><span lang="FA" style="font-size:12.0pt"><span style="line-height:115%"><span b="" lotus="" style="font-family:">)</span></span></span> <span lang="AR-SA" style="font-size:12.0pt"><span style="line-height:115%"><span b="" lotus="" style="font-family:">بود.</span></span></span></span></span></span><br>
<span style="tab-stops:167.8pt"><span style="direction:rtl"><span style="unicode-bidi:embed"><span calibri="" style="font-family:"><b><span lang="FA" style="font-size:12.0pt"><span style="line-height:115%"><span b="" lotus="" style="font-family:">نتیجهگیری: </span></span></span></b></span></span></span></span></span></span><span dir="RTL" lang="FA" style="font-size:12.0pt"><span style="line-height:107%"><span b="" lotus="" style="font-family:">براساس </span></span></span><span style="font-size:11pt"><span style="line-height:115%"><span style="tab-stops:167.8pt"><span style="direction:rtl"><span style="unicode-bidi:embed"><span calibri="" style="font-family:"><span lang="FA" style="font-size:12.0pt"><span style="line-height:115%"><span b="" lotus="" style="font-family:">شواهد موجود؛ مواجهه با کادمیم منجر به افزایش خطر ابتلا به سرطان پستان میگردد و این افزایش خطر از نظر آماری معنیدار است.</span></span></span><b><span lang="FA" style="font-size:12.0pt"><span style="line-height:115%"><span style="font-family:"B Lotus""></span></span></span></b></span></span></span></span></span></span><br>
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<div style="text-align: justify;"><span style="font-size:11pt"><span style="line-height:150%"><span calibri="" style="font-family:"><b><span style="line-height:150%"><span new="" roman="" style="font-family:" times="">Background and Objective:</span></span></b><b> </b><span style="line-height:150%"><span new="" roman="" style="font-family:" times="">Breast cancer is the most common malignancy in women worldwide. Cadmium is one of the most persistent and toxic heavy metals, exposure to which may lead to an increased risk of breast cancer. This study aims to quantitatively summarize the available evidence for the relationship between cadmium exposure and the risk of breast cancer using a systematic review and meta-analysis.</span></span><b><span dir="RTL" lang="AR-SA" style="font-size:12.0pt"><span style="line-height:150%"><span style="font-family:"B Lotus""></span></span></span></b></span></span></span><br>
<span style="font-size:11pt"><span style="line-height:150%"><span calibri="" style="font-family:"><b><span style="line-height:150%"><span new="" roman="" style="font-family:" times="">Materials and Methods:</span></span></b><span style="line-height:150%"><span new="" roman="" style="font-family:" times=""> In this research, observational studies that investigated the relationship between cadmium and breast cancer until May 2022 and were published in international databases were searched and retrieved. To determine the heterogeneity, the statistical tests Chi<sup>2</sup> and I<sup>2</sup> were used, to determine the presence of publication bias Egger's and Begg's tests were used, and to detect the root of the heterogeneity, meta-regression, and sensitivity analysis were used. </span></span><span dir="RTL" lang="AR-SA" style="font-size:12.0pt"><span style="line-height:150%"><span style="font-family:"B Lotus""></span></span></span></span></span></span><br>
<span style="font-size:11pt"><span style="line-height:150%"><span calibri="" style="font-family:"><b><span style="line-height:150%"><span new="" roman="" style="font-family:" times="">Results:</span></span></b><span style="line-height:150%"><span new="" roman="" style="font-family:" times=""> In this study, it was observed that compared to the base group, the relative risk of breast cancer in people exposed/exposed to a dose higher than the base level of cadmium is equal to 1.10 (95% CI: 1.06-1.14; p ≤ 0.001), therefore, a statistically significant relationship was observed between exposure to cadmium or exposure to levels exceeding the baseline and developing breast cancer. In investigating the possibility of publication bias, the result of Egger's test was equal to (p ≥ 0.001), and the result of Bagg's test was equal to (p = 0.099).</span></span></span></span></span><br>
<span style="font-size:11pt"><span style="line-height:150%"><span calibri="" style="font-family:"><b><span style="line-height:150%"><span new="" roman="" style="font-family:" times="">Conclusion: </span></span></b><span style="line-height:150%"><span new="" roman="" style="font-family:" times="">According to the available evidence, exposure to cadmium leads to an increase in the risk of breast cancer, and this increase in risk is statistically significant.</span></span></span></span></span><br>
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خطر نسبی, سرطان پستان, کادمیم
Relative risk, Breast cancer, Cadmium
393
412
http://ijhe.tums.ac.ir/browse.php?a_code=A-10-2688-1&slc_lang=fa&sid=1
Parisa
Farahmandian
پریسا
فرهمندیان
parfar1376@Gmail.com