Iranian Journal of Health and Environment
سلامت و محیط زیست
ijhe
Medical Sciences
http://ijhe.tums.ac.ir
1
admin
2008-2029
2008-3718
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fa
jalali
1402
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gregorian
2023
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fa
مقایسه کارایی تابش های فرابنفش خلاء و C در تجزیه داروی رمدسیویر موجود در آب آلوده
Comparing the efficiency of vacuum ultraviolet and ultraviolet-C for the degradation of Remdesivir in the contaminated water
تصفیه آب
تصفیه آب
پژوهشي
Research
<div style="text-align: justify;"><span style="line-height:150%"><span style="direction:rtl"><span style="unicode-bidi:embed"><b><span lang="FA" style="font-size:12.0pt"><span style="line-height:150%"><span b="" lotus="" style="font-family:"><span style="color:#0d0d0d">زمینه و هدف:</span></span></span></span></b><span lang="FA" style="font-size:12.0pt"><span style="line-height:150%"><span b="" lotus="" style="font-family:"><span style="color:#0d0d0d"> اکسیداسیون پیشرفته مبتنی بر تابش فرابنفش خلاء<b> </b>(</span></span></span></span><span dir="LTR" new="" roman="" style="font-family:" times=""><span style="color:#0d0d0d">Vacuum Ultraviolet (VUV)</span></span><span lang="FA" style="font-size:12.0pt"><span style="line-height:150%"><span b="" lotus="" style="font-family:"><span style="color:#0d0d0d">) دسته جدیدی از فرآیندهای تصفیه پیشرفته بوده، لذا هدف مطالعه حاضر، مقایسه کارایی فرایندهای </span></span></span></span><span dir="LTR" new="" roman="" style="font-family:" times=""><span style="color:#0d0d0d">VUV</span></span><span lang="FA" style="font-size:12.0pt"><span style="line-height:150%"><span b="" lotus="" style="font-family:"><span style="color:#0d0d0d"> و تابش فرابنفش </span></span></span></span><span dir="LTR" new="" roman="" style="font-family:" times=""><span style="color:#0d0d0d">C</span></span><span style="font-size:12.0pt"><span style="line-height:150%"><span b="" lotus="" style="font-family:"><span style="color:#0d0d0d"> (</span></span></span></span><span dir="LTR" new="" roman="" style="font-family:" times=""><span style="color:#0d0d0d">Ultraviolet-C (UVC)</span></span><span lang="FA" style="font-size:12.0pt"><span style="line-height:150%"><span b="" lotus="" style="font-family:"><span style="color:#0d0d0d">) در ترکیب با پراکسید هیدروژن (</span></span></span></span><span dir="LTR" new="" roman="" style="font-family:" times=""><span style="color:#0d0d0d">H<sub>2</sub>O<sub>2</sub></span></span><span lang="FA" style="font-size:12.0pt"><span style="line-height:150%"><span b="" lotus="" style="font-family:"><span style="color:#0d0d0d">) و پروکسی مونوسولفات (</span></span></span></span><span dir="LTR" new="" roman="" style="font-family:" times=""><span style="color:#0d0d0d">PMS</span></span><span lang="FA" style="font-size:12.0pt"><span style="line-height:150%"><span b="" lotus="" style="font-family:"><span style="color:#0d0d0d">) در تخریب داروی ضدویروسی رمدسیویر بوده است. </span></span></span></span></span></span></span><br>
<span style="line-height:150%"><span style="direction:rtl"><span style="unicode-bidi:embed"><b><span lang="FA" style="font-size:12.0pt"><span style="line-height:150%"><span b="" lotus="" style="font-family:"><span style="color:#0d0d0d">روش بررسی:</span></span></span></span></b><span lang="FA" style="font-size:12.0pt"><span style="line-height:150%"><span b="" lotus="" style="font-family:"><span style="color:#0d0d0d"> مطالعه تجربی از نوع توصیفی-تحلیلی با فتوراکتور </span></span></span></span><span dir="LTR" new="" roman="" style="font-family:" times=""><span style="color:#0d0d0d">VUV</span></span><span lang="FA" style="font-size:12.0pt"><span style="line-height:150%"><span b="" lotus="" style="font-family:"><span style="color:#0d0d0d"> و </span></span></span></span><span dir="LTR" new="" roman="" style="font-family:" times=""><span style="color:#0d0d0d">UVC</span></span><span lang="FA" style="font-size:12.0pt"><span style="line-height:150%"><span b="" lotus="" style="font-family:"><span style="color:#0d0d0d"> در ترکیب با </span></span></span></span><span dir="LTR" new="" roman="" style="font-family:" times=""><span style="color:#0d0d0d">H<sub>2</sub>O<sub>2</sub></span></span><sub> </sub><span lang="FA" style="font-size:12.0pt"><span style="line-height:150%"><span b="" lotus="" style="font-family:"><span style="color:#0d0d0d">و </span></span></span></span><span dir="LTR" new="" roman="" style="font-family:" times=""><span style="color:#0d0d0d">PMS</span></span><span lang="FA" style="font-size:12.0pt"><span style="line-height:150%"><span b="" lotus="" style="font-family:"><span style="color:#0d0d0d"> برای تخریب رمدسیویر مورد بررسی قرار گرفت. همچنین تاثیر متغیرهای </span></span></span></span><span dir="LTR" new="" roman="" style="font-family:" times=""><span style="color:#0d0d0d">pH</span></span><span lang="FA" style="font-size:12.0pt"><span style="line-height:150%"><span b="" lotus="" style="font-family:"><span style="color:#0d0d0d">، غلظت </span></span></span></span><span dir="LTR" new="" roman="" style="font-family:" times=""><span style="color:#0d0d0d">H<sub>2</sub>O<sub>2</sub></span></span><span lang="FA" style="font-size:12.0pt"><span style="line-height:150%"><span b="" lotus="" style="font-family:"><span style="color:#0d0d0d">، غلظت رمدسیویر، حضور رادیکالخوارها و آنیونها و همچنین زمان ماند هیدرولیکی در فرایند پیوسته در حذف رمدسیویر سنجش شد.</span></span></span></span></span></span></span><br>
<span style="line-height:150%"><span style="direction:rtl"><span style="unicode-bidi:embed"><b><span lang="FA" style="font-size:12.0pt"><span style="line-height:150%"><span b="" lotus="" style="font-family:"><span style="color:#0d0d0d">یافتهها:</span></span></span></span></b><span lang="FA" style="font-size:12.0pt"><span style="line-height:150%"><span b="" lotus="" style="font-family:"><span style="color:#0d0d0d"> نتایج نشان داد که </span></span></span></span><span dir="LTR" new="" roman="" style="font-family:" times=""><span style="color:#0d0d0d">pH</span></span><span lang="FA" style="font-size:12.0pt"><span style="line-height:150%"><span b="" lotus="" style="font-family:"><span style="color:#0d0d0d"> بهینه در فرایند </span></span></span></span><span dir="LTR" new="" roman="" style="font-family:" times=""><span style="color:#0d0d0d">UVC</span></span><span lang="FA" style="font-size:12.0pt"><span style="line-height:150%"><span b="" lotus="" style="font-family:"><span style="color:#0d0d0d"> و </span></span></span></span><span dir="LTR" new="" roman="" style="font-family:" times=""><span style="color:#0d0d0d">VUV</span></span><span lang="FA" style="font-size:12.0pt"><span style="line-height:150%"><span b="" lotus="" style="font-family:"><span style="color:#0d0d0d"> و مشتقات آنها برابر با 7 بوده و با افزودن </span></span></span></span><span dir="LTR" new="" roman="" style="font-family:" times=""><span style="color:#0d0d0d">PMS</span></span><span lang="FA" style="font-size:12.0pt"><span style="line-height:150%"><span b="" lotus="" style="font-family:"><span style="color:#0d0d0d"> و </span></span></span></span><span dir="LTR" new="" roman="" style="font-family:" times=""><span style="color:#0d0d0d">H<sub>2</sub>O<sub>2</sub></span></span><sub> </sub><span lang="FA" style="font-size:12.0pt"><span style="line-height:150%"><span b="" lotus="" style="font-family:"><span style="color:#0d0d0d">به میزان </span></span></span></span><span dir="LTR" new="" roman="" style="font-family:" times=""><span style="color:#0d0d0d">mM</span></span><span lang="FA" style="font-size:12.0pt"><span style="line-height:150%"><span b="" lotus="" style="font-family:"><span style="color:#0d0d0d"> 1، راندمان تخریب رمدسیویر از 0/4 </span></span></span></span><span lang="FA" style="font-size:12.0pt"><span style="line-height:150%"><span new="" roman="" style="font-family:" times=""><span style="color:#0d0d0d">±</span></span></span></span><span lang="FA" style="font-size:12.0pt"><span style="line-height:150%"><span b="" lotus="" style="font-family:"><span style="color:#0d0d0d"> 92/2 درصد پس از </span></span></span></span><span dir="LTR" new="" roman="" style="font-family:" times=""><span style="color:#0d0d0d">min</span></span><span lang="FA" style="font-size:12.0pt"><span style="line-height:150%"><span b="" lotus="" style="font-family:"><span style="color:#0d0d0d"> 30 به ترتیب به 2/1 </span></span></span></span><span lang="FA" style="font-size:12.0pt"><span style="line-height:150%"><span new="" roman="" style="font-family:" times=""><span style="color:#0d0d0d">±</span></span></span></span><span lang="FA" style="font-size:12.0pt"><span style="line-height:150%"><span b="" lotus="" style="font-family:"><span style="color:#0d0d0d"> 98/3 و 0/3 </span></span></span></span><span lang="FA" style="font-size:12.0pt"><span style="line-height:150%"><span new="" roman="" style="font-family:" times=""><span style="color:#0d0d0d">±</span></span></span></span><span lang="FA" style="font-size:12.0pt"><span style="line-height:150%"><span b="" lotus="" style="font-family:"><span style="color:#0d0d0d"> 100 درصد افزایش یافت. همچنین در فرایند </span></span></span></span><span dir="LTR" new="" roman="" style="font-family:" times=""><span style="color:#0d0d0d">VUV</span></span><span lang="FA" style="font-size:12.0pt"><span style="line-height:150%"><span b="" lotus="" style="font-family:"><span style="color:#0d0d0d"> ترکیب شده با </span></span></span></span><span dir="LTR" new="" roman="" style="font-family:" times=""><span style="color:#0d0d0d">H<sub>2</sub>O<sub>2</sub></span></span><sub> </sub><span lang="FA" style="font-size:12.0pt"><span style="line-height:150%"><span b="" lotus="" style="font-family:"><span style="color:#0d0d0d">و </span></span></span></span><span dir="LTR" new="" roman="" style="font-family:" times=""><span style="color:#0d0d0d">PMS</span></span><span lang="FA" style="font-size:12.0pt"><span style="line-height:150%"><span b="" lotus="" style="font-family:"><span style="color:#0d0d0d"> نیز راندمان تخریب پس از </span></span></span></span><span dir="LTR" new="" roman="" style="font-family:" times=""><span style="color:#0d0d0d">min</span></span><span lang="FA" style="font-size:12.0pt"><span style="line-height:150%"><span b="" lotus="" style="font-family:"><span style="color:#0d0d0d"> 40 بهترتیب به 1/5 </span></span></span></span><span lang="FA" style="font-size:12.0pt"><span style="line-height:150%"><span new="" roman="" style="font-family:" times=""><span style="color:#0d0d0d">±</span></span></span></span><span lang="FA" style="font-size:12.0pt"><span style="line-height:150%"><span b="" lotus="" style="font-family:"><span style="color:#0d0d0d"> 77/8 و 1/3</span></span></span></span><span lang="FA" style="font-size:12.0pt"><span style="line-height:150%"><span new="" roman="" style="font-family:" times=""><span style="color:#0d0d0d">±</span></span></span></span><span lang="FA" style="font-size:12.0pt"><span style="line-height:150%"><span b="" lotus="" style="font-family:"><span style="color:#0d0d0d"> 85/2 درصد رسید. کینتیک تجزیه در فرآیندهای مورد بررسی به شرح</span></span></span></span><span dir="LTR" new="" roman="" style="font-family:" times=""><span style="color:#0d0d0d">VUV/H<sub>2</sub>O<sub>2</sub>> VUV/PMS > VUV> UVC/H<sub>2</sub>O<sub>2</sub> >UVC/PMS > UVC</span></span><span style="font-size:12.0pt"><span style="line-height:150%"><span b="" lotus="" style="font-family:"><span style="color:#0d0d0d"> بوده است. نتایج رادیکالخواری نیز نشان داد که رادیکال هیدروکسیل، اصلیترین گونه فعال اکسیژن بوده که منجر به تخریب رمدسیویر میشود. سیستم پیوسته </span></span></span></span><span dir="LTR" new="" roman="" style="font-family:" times=""><span style="color:#0d0d0d">VUV/H<sub>2</sub>O<sub>2</sub></span></span><sub> </sub><span lang="FA" style="font-size:12.0pt"><span style="line-height:150%"><span b="" lotus="" style="font-family:"><span style="color:#0d0d0d">نیز نشان داد که راندمان حذف رمدسیویر پس از </span></span></span></span><span dir="LTR" new="" roman="" style="font-family:" times=""><span style="color:#0d0d0d">min</span></span><span lang="FA" style="font-size:12.0pt"><span style="line-height:150%"><span b="" lotus="" style="font-family:"><span style="color:#0d0d0d"> 40 به 0/8 </span></span></span></span><span lang="FA" style="font-size:12.0pt"><span style="line-height:150%"><span new="" roman="" style="font-family:" times=""><span style="color:#0d0d0d">±</span></span></span></span><span lang="FA" style="font-size:12.0pt"><span style="line-height:150%"><span b="" lotus="" style="font-family:"><span style="color:#0d0d0d"> 94/7 درصد رسید.</span></span></span></span></span></span></span><br>
<span style="line-height:150%"><span style="direction:rtl"><span style="unicode-bidi:embed"><b><span lang="FA" style="font-size:12.0pt"><span style="line-height:150%"><span b="" lotus="" style="font-family:"><span style="color:#0d0d0d">نتیجهگیری:</span></span></span></span></b><span lang="FA" style="font-size:12.0pt"><span style="line-height:150%"><span b="" lotus="" style="font-family:"><span style="color:#0d0d0d"> با توجه به نرخ بالای حذف رمدسیویر و بهبود فرآیند حذف با افزودن </span></span></span></span><span dir="LTR" new="" roman="" style="font-family:" times=""><span style="color:#0d0d0d">H<sub>2</sub>O<sub>2</sub></span></span><span lang="FA" style="font-size:12.0pt"><span style="line-height:150%"><span b="" lotus="" style="font-family:"><span style="color:#0d0d0d">، میتوان فرآیند </span></span></span></span><span dir="LTR" new="" roman="" style="font-family:" times=""><span style="color:#0d0d0d">VUV/H<sub>2</sub>O<sub>2</sub></span></span><sub> </sub><span lang="FA" style="font-size:12.0pt"><span style="line-height:150%"><span b="" lotus="" style="font-family:"><span style="color:#0d0d0d">را یک تکنولوژی کارآمد برای حذف داروهای ضدویروسی معرفی کرد.</span></span></span></span></span></span></span><br>
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<div style="text-align: justify;"><span style="line-height:150%"><b><span new="" roman="" style="font-family:" times=""><span style="color:#0d0d0d">Background and Objective: </span></span></b><span new="" roman="" style="font-family:" times=""><span style="color:#0d0d0d">Vacuum Ultraviolet (VUV)-based advanced oxidation is a new category of advanced purification processes, so this study aimed to compare the efficiency of VUV and Ultraviolet-C (UVC) processes in combination with H<sub>2</sub>O<sub>2</sub> and PMS in degrading Remdesivir.</span></span></span><br>
<span style="line-height:150%"><b><span new="" roman="" style="font-family:" times=""><span style="color:#0d0d0d">Materials and Methods:</span></span></b><span new="" roman="" style="font-family:" times=""><span style="color:#0d0d0d"> The photoreactor was investigated with VUV and UVC lamps in combination with H<sub>2</sub>O<sub>2</sub> and PMS for Remdesivir degradation. Also, the effect of variables such as solution pH, H<sub>2</sub>O<sub>2</sub> dose, Remdesivir concentration, the presence of radical scavengers and anions, as well as hydraulic retention time was considered in the continuous process of Remdesivir removal.</span></span></span><br>
<span style="line-height:150%"><b><span new="" roman="" style="font-family:" times=""><span style="color:#0d0d0d">Results:</span></span></b><span new="" roman="" style="font-family:" times=""><span style="color:#0d0d0d"> The findings showed that</span></span> <span new="" roman="" style="font-family:" times=""><span style="color:#0d0d0d">the optimal pH in the processes of VUV, UVC, and their derivatives was equal to 7. By adding 1 mM of PMS and H<sub>2</sub>O<sub>2</sub> to the VUV process, the degradation efficiency of Remdesivir was increased from 92.2 ± 0.4% to 98.3 ±2.1% and 100 ± 0.3%, respectively, after 30 min. Also, in the UVC process combined with H<sub>2</sub>O<sub>2</sub> and PMS, the degradation efficiency reached 77.8 ± 1.5 and 85.2 ± 1.3% after 40 min, respectively. The degradation kinetics in the examined processes were as follows: VUV/H<sub>2</sub>O<sub>2</sub> > VUV/PMS > VUV > UVC/H<sub>2</sub>O<sub>2</sub> > UVC/PMS > UVC. The hydroxyl radical was the main reactive oxygen species that led to the decomposition of Remdesivir. The continuous operation of VUV/H<sub>2</sub>O<sub>2</sub> showed that the removal efficiency of Remdesivir reached 94.7 ±0.8% after 40 min.</span></span></span><br>
<span style="line-height:150%"><b><span new="" roman="" style="font-family:" times=""><span style="color:#0d0d0d">Conclusion:</span></span></b><span new="" roman="" style="font-family:" times=""><span style="color:#0d0d0d"> Considering the high rate of Remdesivir degradation by adding H<sub>2</sub>O<sub>2</sub>, the VUV/H<sub>2</sub>O<sub>2</sub> process can be introduced as an efficient technology for the removal of antiviral drugs.</span></span></span><br>
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آلایندههای نوظهور, رمدسیویر, فرایند اکسیداسیون پیشرفته, رادیکال هیدروکسیل
Emerging contaminants, Remdesivir, Advanced oxidation process, Hydroxyl radical
129
148
http://ijhe.tums.ac.ir/browse.php?a_code=A-10-232-2&slc_lang=fa&sid=1
Mahboobeh
Motalebi
محبوبه
مطلبی
m.motalebi@modares.ac.ir