http://jdc.tums.ac.ir Journal of Dermatology and Cosmetic - Journal articles for year 2014, Volume 5, Number 3 Yektaweb Collection - https://yektaweb.com en 2014/10/9 http://journals.tums.ac.ir/jdc/browse.php?a_id=5080&sid=1&slc_lang=en Background and Aim: Wart is one of the most common viral diseases of skin caused by human papilloma virus (HPV) and results in high costs for therapeutic, cosmetic and hygienic interventions. Euphorbia is an annual plant belonging to Euphorbiaceae family that has seventy species. All of them have latexes with high medicinal values. These plants have anti-viral and anti-tumor substances and 10 species of them are used in traditional medicine for treatment of ulcers, tumors, warts, and other diseases. In this study, the therapeutic effect of Euphorbia macrolada latex on common warts is compared with the standard keratolytic treatment. Methods: The latex of E. macrolada was prepared from Dehgolan region in Kurdistan Province and used directly. The standard keratolytic solution, which contained 16.7 g salicylic acid, 16.7 g lactic acid and up to 100 g collodion was prepared and delivered by the Hamedan Behzisti Pharmacy. A double-blind trial was conducted in Farshchian Hospital, Hamedan, Iran on 88 patients (44 in each group). They were instructed to apply the solutions on their warts twice daily for maximum of 8 weeks. Results: All lesions in both groups were cured after 8 weeks. The meanstandard deviation (SD) of time to cure was 4.51.4 weeks in E. macrolada group and 5.11.6 weeks in the control group. None of these differences were statistically significant (P>0.05). No adverse effects was observed in any of patients. Conclusion: The findings indicated that E. macrolada had a therapeutic effect on common warts. Based on the results of this study, latex of this plant can be used as a complementary or alternative medicine in the treatment of patients with common warts. Ameneh Yazdanfar http://journals.tums.ac.ir/jdc/browse.php?a_id=5081&sid=1&slc_lang=en Background and Aim: Moisturizers have important roles in the treatment of dry skin. Their safety has to be evaluated on human volunteers in order to assess their potential skin irritation. Measurements of skin biophysical parameters can be used as fast and noninvasive methods to assess any harmful effect of cosmetic formulations on the skin sites where those products are applied. Methods: Two moisturizers were selected from Iran's market to determine the changes in Trans Epidermal Water Loss (TEWL), stratum corneum hydration, pH, melanin and hemoglobin contents by biometric assessments with MPA 580 Cutometer®. Results: There was no any significant change in TEWL, skin pH, melanin and hemoglobin contents before and after products application. Stratum corneum hydration was increased after application of Neu Derm Renutrive Honey Shea from 0.09 to 0.39 (P0.001). Neu Derm Optimal Hydrosense increased stratum corneum hydration from 0.23 to 0.48 (P0.001). Conclusion: Application of the studied moisturizers on human volunteers did not show any adverse effect. So, those products could be recommended for safe use. Significant changes in the stratum corneum hydration associated with application of each moisturizer were related to humectant ingredients which were used in each product. Saman Ahmad Nasrollahi http://journals.tums.ac.ir/jdc/browse.php?a_id=5082&sid=1&slc_lang=en Background and Aim: Pityriasis versicolor (PV) is a fungal infection of the skin that is caused by Malassezia species in tropical and subtropical areas. Various treatments such as ketoconazole 2% shampoo are effective in the treatment of PV. In this study, the therapeutic effects of ketoconazole 2% shampoo and Octopirox 1% shampoo on PV were compared. Methods: Fourty-two patients participated in the study. Twenty-five patients were treated using Octopirox 1% shampoo and 17 patients were treated by ketoconazole 2% shampoo. Each shampoo was administered for 5 minutes after daily showers for three weeks. At the end of the treatment period, patients were evaluated on the basis of the results KOH test and clinical examinations. Results: At the end of the treatment period in ketoconazole 2% shampoo group, 64.7% of patients were cured. In Octopirox 1% shampoo group, 44% of patients were cured. The detected difference was not statistically significant (P=0.187). Conclusion: Both shampoos were effective in eliminating the symptoms, but ketoconazole 2% shampoo was more effective in improving the associated hyperpigmentation and erythema than Octopirox 2% shampoo. No side effects were observed in either group. Nasrin Hamidizadeh http://journals.tums.ac.ir/jdc/browse.php?a_id=5083&sid=1&slc_lang=en Background and Aim: Malignant melanoma is a rare and most malignant type of skin cancer which is originated from melanocytes. It is capable of infiltrating into interior organs and could cause mortality. The aim of this study is to analyze the survival of patients with malignant melanoma according to their age, gender, mitosis count, tumor thickness, level of lymphocyte infiltration, tumor location and the stage of the tumor. Methods: This is a descriptive-analytical study which has been done on, the data of 61 patients with malignant melanoma registered in pathology laboratory of Shahid Sadoughi hospital, Yazd. A questionnaire was used to collect the data via phone call, examining pathology slides and reviewing patients information. Results: The average survival time was 61.09±6.12 months.The mean age of the patients was 67.9±6.0 with the range of 18 to 89 years. Stage Ι had the best and stage ΙΙΙ and VΙ had the worst prognosis. The best survival rate was seen in malignant melanomas located on trunk, head and neck. Malignant melanoma of extremities had the worst prognosis. There was a statistically significant relationship between survival rate and stage (P=0.033) as well as the location of the tumor (P=0.0421). Conclusion: The survival of patients with malignant melanoma in Yazd had a statistically significant relationship with stage and the location of tumor but there was no significant relationship with mitosis count, gender, age, tumor depth and lymphocyte infiltration. Mohammd Ebrahimzade Ardakani http://journals.tums.ac.ir/jdc/browse.php?a_id=5084&sid=1&slc_lang=en Background and Aim: Vitiligo is a common skin disease and it is important to recognize and manage its social and psychological consequences. The aim of this study was to investigate the relationship between illness perception, depression and quality of life among vitiligo patients referred to the skin clinic of Farshchian Hospital in Hamedan. Methods: This cross sectional study was conducted on the patients with vitiligo referred to the skin clinic of Farshchian Hospital during the first quarter of 2014. The study sample consisted of 100 patients (32 male and 68 female patients) with vitiligo who were selected using convenience sampling. Measurement tools included the Revised Illness Perception Questionnaire (IPQ-R), World Health Organization Quality of Life-BREF (WHOQOL-BREF), and Beck Depression Inventory-II (BDI-II). The data were analyzed using Pearson's correlation test. Results: Illness perception have significant relationship with depression and quality of life in vitiligo patients. There was a significant difference in positive (P=0.031) and negative (P=0.002) illness perception scores between male and female vitiligo patients. Also, environmental dimension of quality of life in vitiligo patients was significantly different between men and women (P=0.031). Conclusion: Evaluation of quality of life and depression in patients with vitiligo to reduce the adverse consequences of the disesase on patients' lives is recommended. Hamze Ahmadian http://journals.tums.ac.ir/jdc/browse.php?a_id=5085&sid=1&slc_lang=en Psoriasis is a chronic inflammatory disease which may occur in childhood. In many psoriasis cases, the disease develops in individuals younger than 18 years old. Psoriasis in children presents with a variety of clinical manifestations. Becouse of its atypical presentations, early diagnosis of psoriasis is difficult in children. The plaque type psoriasis is the most common form of the disease in children. Different treatments such as phototherapy and systemic therapies have been proposed, but using any of them leads to serious complications in children. Therefore, early diagnosis and proper management of the disease are the main components of the treatment in pediatric psoriasis cases. Herein, we aimed to provide a general overview on the pediatric psoriasis, including its epidemiology, pathogenesis, clinical manifestations as well as the treatment and discussing the latest related information. Mehrdad Taghipour http://journals.tums.ac.ir/jdc/browse.php?a_id=5086&sid=1&slc_lang=en Paederus dermatitis is a common dermatitis in northern parts of Iran. Clinically, the most common presentation of paederus dermatitis is sudden onset of erythematous plaques with vesicles. The lesions usually affect exposed areas such as face, neck and arms. It is a common dermatitis between residents and tourists in northern provinces of Iran during spring and summer. Preventive measures include typical insect repellents precautions, such as using bed nets, long-sleeve clothing, and avoiding fluorescent lights. If the beetles are found on the skin, brushing them off, rather than crushing them, helps to prevent the dermatitis. Treatment includes washing the affected area immidiatley, applying cold and wet compresses, and in some cases, treatment with antibiotics, steroids, and antihistamines. Herein, we report a paederus dermatitis case in a 9-year old Kashani boy who had traveled to northern Iran as a tourist. We also review the related literature. Rezvan Talaee