Dermatology and Cosmetic

Editorial Note

Mansour Nassiri Kashani

No Absract No Absract

Management of urticaria: Iranian Society of Dermatology clinical practice guideline

Alireza Firooz

Urticaria is a common and challenging skin disorder. Diagnosis and treatment of urticaria is not limited to the field of dermatology. General physicians, internal medicine specialists, allergologists and clinical immunologists are also commonly involved in the management of patients with urticaria.
Iranian Society of Dermatology developed a clinical practice guideline concerning diagnosis and treatment of urticaria that was published in 2018. The current guideline is the result of scientific papers that got published from April 2018 to August 2022.

Tolerability and efficacy of an oral collagen supplement for the improvement of biophysical and ultrasonographic parameters of skin

Aniseh Samadi

Background and Aim: Oral hydrolyzed collagen is one of the newest and most popular systemic supplementations for skin rejuvenation. However, there are limited information in case of Middle Eastern consumers. The purpose of this study was to evaluate the tolerability and efficacy of an oral collagen supplement for improvement of skin elasticity, hydration and roughness.

Methods: It was a 12-week, before-after clinical study, conducted on 20 participants (18 women and two men) aged 44.15±5.36 years with skin type III-IV. Skin elasticity parameters (R0, R2, R5 and R7), skin hydration and friction, as well as the thickness and echo density of the dermis, were measured after six and 12 weeks daily intake of the study product, as well as four weeks after stopping its use (week 16). Participants’ satisfaction was assessed on the basis of their answers to the standard questionnaire, and tolerability of the product was assessed by monitoring the adverse effects.

Results: A significant improvement was detected in R2, R5 and skin friction at week 12 (P<0.041, P<0.012 and P<0.01, respectively). At week 16, the values remained at an increased level, which indicates the stability of the results. The increase of dermis density in week 16 was also significant (P=0.03). Moderate overall satisfaction was reported with the treatment, and a few gastrointestinal complications were reported.

Conclusion: The study demonstrated that oral collagen peptides could significantly improve the skin elasticity, roughness, and dermis echo density, and they also proved to be safe and well-tolerated.

Demographic and histological characteristics of patients with tattoo-granuloma in Razi Hospital

Amirhossein Rahimnia

Background and Aim: One of the most important pathologies of tattooing is granulomatous reaction to the tattoo which is usually represented by symptoms like pain, inflation, redness and tenderness at the tattoo area. Granulomatous reaction to tattoo occurs at all ages and has been seen among both male and female. Due to the new rise in popularity of cosmetic tattoos and its pathologies, we intend to explore a descriptive study of the demographic and histopathologic characteristics of the granulomatous reactions due to cosmetic tattoos.

Methods: Razi hospital patients with proven tattoo granuloma pathology in a 3-year period were identified and studied and their demographic-histological characteristics were recorded. The study is of a cross-sectional type. 196 patients were enrolled in the study, a questionnaire was prepared for each patient and information was collected through them.

Results: The mean ± standard deviation age of the patients was 45.46±8.54. The mean ± standard deviation tattoo time was 4.18±4.33. The mean ± standard deviation frequency of tattooing was 1.64±1.8. The most common tattoo area was eyebrow in 88.3% of the patients and least common was upper eyelid in 0.6%. The most common pathology result was tattoo granuloma in 41.7% of the patients and the least common was Lichenoid in 2.8%.

Conclusion: Considering the highest frequency of pathological diagnosis of tattoo-granuloma (Sarcoidal and foreign body) with 41.7% in our study and observing the relationship between tattoo-granuloma and sarcoidosis in previous studies, complete examination of patients, long-term follow-up of patients which will have sarcoidosis in the future and examining the clinical response to treatment seems logical and beneficial. It is also important to consider whether the treatment of current lesions will play a role in preventing sarcoidosis in the future or not.

Histopathological and immunohistochemical evaluation of the effect of polar extract of Plantago lanceolata on open wound healing in Wistar rat skin

Soroush Mohitmafi

Background and Aim: The purpose of this study is to investigate the histopathology and immunohistochemistry of the effect of 5% Plantago labceolata. extract on open wound healing in rat skin.

Methods: After extracting the plant extract using the mixed method, 40 healthy male rats with an average weight of 200-250 grams were selected and randomly divided into two main groups of 20. Group 1 is the treatment group and group 2 the control group each of the main groups being divided into 4 subgroups (days 3, 7, 14,21) were divided. For the histopathological and immunohistochemical investigation of the healing process, the wounds of the mice of the subgroups in both the main groups were removed in full thickness and with a diameter of 15 mm and examined for histological studies. After sectioning, with the qualitative staining method of hematoxylin eosin and Masson's trichrome,using antibodies against transforming growth factor beta and vascular endothelial growth factor of the study groups, and the obtained information was converted into quantitative information. and was subjected to statistical analysis.

Results: Finding this study has shown that about 95% of women had felt at least one problem in their hands. During COVID-19 pandemic, hand washing with disinfectants were repeated more and more, furthers skin of the hands will be two times more damaged as compared to normal conditions, so the need to increase hand health training as part of general health, especially in older adults' women in advance.

Conclusion: The results show that it is possible to use the polar extract of Plantago Lanceolata L. plant 5% for wound healing.

A review of the effects of Reishi mushroom (Ganoderma lucidum) on skin health and diseases

Sharareh Rezaeian

Reishi mushroom (Ganoderma lucidum) is a unique medicinal mushroom that has been used for the treatment of various diseases in Asian countries for more than 4 thousand years. Today, this mushroom is also used in treatments related to traditional medicine. In addition to its diverse biological properties, its positive effects in improving the quality of the skin and treating skin diseases have attracted the attention of researchers. Polysaccharides and triterpenes are among the most important and effective metabolites of this mushroom, which are important in skin treatment and health due to their antioxidant and anti-inflammatory functions. This review summarizes the latest research achievements on the role of this mushroom in skin health and treatment. A number of studies have shown that the extracts of Reishi mushroom can accelerate wound healing, relieve post-burn infections, and prevent skin flaps due to ischemia (re-perfusion) damage. The effect of Reishi mushroom extracts on the prevention and treatment of wrinkles and the effect on skin whitening has made them a natural ingredient for skin care. Also, studies conducted on the effects of Reishi mushroom in the treatment of some skin diseases such as atopic dermatitis (eczema), cutaneous sarcoidosis, and the potential use of this mushroom in the treatment of skin cancer have been discussed.

A review of different methods of skin care using cyanobacteria

Bahareh Nowruzi

Microalgae are photosynthetic microorganisms which are the result of permanent exposure to stressful conditions such as high or low temperature, high salinity, osmotic pressure, ultraviolet radiation (uv), contain valuable bioactive compounds in cosmetic products .the existing cosmetic products can be replaced with the cosmetic products that are compatible with the environment and can be included in the topical formulations of skin care such as moisturizers, Anti-wrinkles, anti - aging and anti - acne. In addition, the extracts from these microalgae are used to make sunscreen to treat skin pigmentation and improve wounds; therefore most commercial cosmetics have a wide range of natural compounds extracted from cyanobacteria and this leads to increasing antioxidant, regenerative, moisturizer, shielding and brighteners for both hair and skin. In this article the cosmetic use of cyanobacteria extract and dried powder in improving the appearance and health skin have been investigated. Furthermore, analyzing the brand of Spirulina has been discussed.

Cutaneous reaction due to Tarantula bites on human leg: a report of two cases

Esmaeil Alizadeh

Background: Tarantulas (Camel spiders) are order that belong to classes of arachnida and phylum of arthropoda. They can make a painful bite in human.

Case Report: This paper presents 34 and 40-year-old men with skin reactions in their left legs. After initial examinations, the symptoms were recognized as skin reaction caused by the bite of some nuisance insects. After one day, a lesion including 2 red dots appeared on the patient's leg. After a few hours, skin lesions were observed in both patient, and by washing with soap and water after 7 days, the symptoms completely disappeared and the bite improved.

Conclusion: Increasing awareness among physicians, about the symptoms of this nuisance insects can help to accelerate treatment process.