Dermatology and Cosmetic

Editorial Note

Mansour Nassiri Kashani

No Abstract

Evaluation of topical cream stability obtained from aqueous extract of Sargassum tenerrimum brown algae

Moazameh Kordjazi

Background and Aim: Marine seaweeds are a valuable source of bioactive ingeredients with the possibility of different effects in cosmeceutical industries such as skin health products. One of the main characteristics of the skin is moisture which plays an important role in maintaining metabolism, enzymatic activity, mechanical properties, appearance and protective barrier. The objective of the present study was to formulate the water extract of brown algae Sargassum tenerrimum with antioxidant and antibacterial properties as a moisturizing cream to evaluate physicochemical stability and microbial growth.

Methods: Algae were collected from the Persian Gulf intertidal zone and was washed with seawater, then transferd to Seafood Processing Laboratory in Gorgan University of Agricultural Sciences and Natural Resources for extraction process, after that formulation of 1% moisturizing cream was made at Center for Research and Training in Skin Diseases and LeprosyTehran University of Medical Scinces. Statistical analysis of antibacterial properties of water extract was performed by SPSS software version 22 and one way ANONA was used to analyse the data. The comparison between the means were investigated by Duncan’s test used for measuring significant differences at 5 percent level. Finally, the charts were created by using Excel software. The results of the study were reported as mean ± standard deviation.

Results: According to the results, the prepared 1% cream was completely stable and homogeneous in room temperature and oven for 6 months and successfully passed microbial tests.

Conclusion: In view of the above mentioned, the manufactured cream efficacy was well done and can be introduce as a skin moisturizing agent.

The use of adult stem cells in the treatment of skin diseases

Mahdieh Ghiasi

The skin, as the outer layer, protects the body against external factors. Wounds can negatively affect its performance. Wound healing includes three stages of inflammation, proliferation, and regeneration, which begin immediately after injury. Also, some factors such as infection, obesity and diabetes can disrupt the natural healing process that leads to chronic wounds. Various surgical and non-surgical treatments have been used to manage chronic wounds, including hyperbaric oxygen therapy, ultrasound therapy, laser therapy, and skin grafting. These treatments have advantages and disadvantages. Recently, stem cells have been used as a surgical treatment for chronic wound healing. Stem cells are highly proliferative cells that can maintain their ability to divide and regenerate for a long time. Among the different types of stem cells, MSCs have many advantages such as ease of harvest, availability, and multilineage differentiation capacity for cell therapy. In addition, they showed some properties that could be useful in the clinical application of ASCs, including angiogenesis, immune system modulation, and improved tissue regeneration. This study was conducted by collecting data from reliable scientific sources from April 1401 to January 1402 at the Research Institute of Neurosciences, Brain and Spinal Cord Injury Research Center of Tehran University of Medical Sciences. Several studies have shown that ASCs can be a suitable candidate for wound healing due to their special characteristics. The purpose of this review is to discuss the use of ASCs in wound repair and healing as a new strategy in the treatment of skin problems.

A review of hyaluronic acid/polycaprolactone dermal fillers for skin beauty applications

Nahid Hassanzadeh Nemati

Cosmetic dermatology has seen significant advancements in developing new materials and techniques to enhance skin beauty and combat signs of aging. One notable development is creating and analyzing fillers made by combining hyaluronic acid and polycaprolactone. This innovative filler type has gained popularity due to its unique properties, exceptional skin rejuvenation capabilities, and effectiveness in facial contouring. This study gathered information on dermal fillers and the effects of using hyaluronic acid and polycaprolactone by referencing papers from various databases such as Civilica, PubMed, Google Scholar, Science Direct, and SID. The authors conducted a study to explore the benefits and drawbacks of utilizing hyaluronic acid and polycaprolactone and their impact on filler durability and injectability. Research conducted by experts and studies on cosmetic fillers has highlighted the positive effects of hyaluronic acid and polycaprolactone, two powerful substances widely discussed in the beauty industry. Further research could improve the understanding and utilization of hyaluronic acid/polycaprolactone fillers, enhancing skin cosmetic treatments and increasing patient satisfaction.

Chitosan; a promising natural biopolymer in skin care products

Faezeh Kashanian

Chitosan biopolymer, due to its antimicrobial, anti-inflammatory, and antioxidant properties, has become an ideal candidate for use in a wide range of cosmetic products and has opened up new horizons in the design of cosmetic formulations. The ability of this polymer to electrostatically interact with negatively charged surfaces (such as damaged skin) leads to the formation of polymeric films and ultimately imparts smoothness and moisture to cosmetic products. This review article revisits the potential of chitosan and its derivatives as raw materials in cosmetic and skincare products.

A review of the properties of Algae polymers in the treatment and dressing of skin wounds

Bahareh Nowruzi

Worldwide, 16,000 deaths occur daily due to wound injuries, leading to increased concern in low- and middle-income countries. Today, with the increasing demand of consumers to use natural biological compounds instead of using harmful and carcinogenic chemical compounds, algae were introduced to the market as an effective clinical skin alternative. In fact, ease of cultivation and low nutritional requirements make algal polysaccharides an attractive alternative for advanced wound dressings. Micro and macroalgae are a new source of biological saccharide polymers for wound healing. The hydrophilic nature of these polymers due to their capacity to trap water molecules in their structure makes hydrogels that have a high ability to absorb and release liquid. In this review article, by studying the latest articles, some algae polysaccharides that are widely used as wound healing dressings such as alginates, fucoidans, carrageenans, laminarin, agar-agar and olvan are discussed. These compounds are not only used as functional biomaterials for controlled drug delivery, but also for cell stabilization and preparation of scaffolds for tissue engineering.

Janus kinase inhibitors and malignancy

Zahrabeigom Moosavi

Development of janus kinase inhibitors (JAKi), has significantly modified treatment of various dermatological conditions by targeting essential pathogenesis of inflammatory and autoimmune diseases. Despite therapeutic potentials of these drugs, concerns about safety appeared soon postmarketing consumption. Therefore implementing strong studies to evaluate their safety and efficacy became mandatory. Many studies have been done up to now focusing on JAKi’s serious or acceptable side effects, however, they are often retrospective or have short follow up. Due to importance of JAKi’s role in the treatment of many skin diseases, we decided to present a review on the main points of recent studies, particularly systematic reviews and clinical trials regarding serious side effects.

Cutaneous reaction due to spider bites in a seven-year-old boy in Qeshm Island: A case report

Ismaeil Alizadeh

Background and Aim: Spiders are one of the largest orders of arachnids, found worldwide on all continents except Antarctica. Many species of spiders live in close proximity to humans and generally inject poison into other animals, including humans, to protect themselves or to hunt.
Case Report: In this paper, a seven-year-old boy is presented who came to the hospital complaining of skin reactions in the eye, knee, and lower leg area. Skin lesions appeared on the boy's body after a few hours. After 24 hours, the skin lesions intensified, and inflammation and redness along with itching occurred on the boy's body. Finally, after 5 days, the skin lesions disappeared completely by washing with soap and water along with the use of Calamine lotion and the bite site improved.
Conclusion: Increasing awareness among physicians, about the symptoms of this nuisance insects can help to accelerate treatment process.