Showing 26 results for Psoriasis
Houshang Nemati, Mozafar Khazaei, Mehri Nazeri, Maryam Bozorgi,
Volume 13, Issue 1 (5-2022)
Abstract
Background and Aim: Psoriasis is a chronic inflammatory skin disease, influenced by genetic and immune-based factors that is associated with skin inflammation. Aloe vera gel is traditionally used to treat skin diseases including psoriasis.
Methods: In this study, ethanolic extract of aloe vera gel was evaluated for its anti-inflammatory and antioxidant activity in skin-derived A431 cells. First, after preparing the extract and then the green synthesis of gold nanoparticles using the extract, their effect on the expression of inflammatory genes as well as their antioxidant properties were investigated.
Results: The use of different concentrations of aloe vera extract caused a relative increase in EGFR and Nrf2 expression levels and decreased expression of NF-κB, TNF-α and IL-6 inflammatory genes in A431 skin cells. But the effect of synthesized nanoparticles was greater than aloe vera extract in altering the expression of signaling and inflammatory genes.
Conclusion: The synthesized extracts and nanoparticles had antioxidant properties and also reduced the expression of inflammatory genes in cells. However, the effect of nanoparticles was much greater than that of extracts in reducing inflammatory genes.
Ensieh Lotfali, Adel Shirani, Sina Molavizade, Sa’adat Shojaei,
Volume 13, Issue 1 (5-2022)
Abstract
Onychomycosis is a nail infection caused by dermatophyte and non-dermatophyte molds and yeasts. The nail involvement is a feature of psoriasis, although skin manifestations are the most principal findings in psoriasis. Onychomycosis and psoriasis are both common disorders in communities. It is possible that in some patients these two diseases are present at the same time. A review was performed using the keywords including nail psoriasis, onychomycoses, dermatophytes, non-dermatophyte molds and yeasts in valid medical databases, such as PubMed, Google scholar, Scopus and Science direct. Articles that were most relevant to the purpose of the study were selected and studied. We investigated the incidence and pathogenic function of fungal agents in causing fungal infections in psoriasis nails.
Mahbobeh Dehghan Nayeri, Mohammadhossein Bayazi,
Volume 14, Issue 1 (5-2023)
Abstract
Background and Aim: The purpose of this research was to compare the effectiveness of cognitive behavioral and emotion-focused group therapy on reducing the symptoms of psoriasis, psychological distress and perception of body image.
Methods: This was a semi-experimental research of pretest posttest type with a control group. The statistical population of this research included all patients who were diagnosed with psoriasis in spring of 2022 by referring to dermatologists in Mashhad. 45 psoriasis patients were selected by available sampling method and replaced randomly in two experimental groups (CBT and EFT) and control group (each groups 15). The experimental groups was treated for 8 sessions, one session of 90 minutes per week. The control group received no intervention. Parents completed the Psychological Distress Scale, Body Image Concern Inventory and the Physical Symptoms Questionnaire with Psoriasis Area Severity Index before and after the treatment sessions. The data were analyzed by Analysis of covariance.
Results: The findings showed that cognitive-behavioral and emotion-focused reduced psychological distress (P<0.01, F=21.06), improved perception of body image (P<0.01, F=33.65) and reducing the severity of psoriasis symptoms (P>0.01, F=12.67) are effective. Also, cognitive behavioral therapy is more effective method to reduce psychological distress and improve perception of body image (P<0.01). However, there is no significant difference between the effectiveness of cognitive-behavioral therapy and emotion-focused therapy in reducing psoriasis symptoms of patients (P<0.05).
Conclusion: Both therapies can play a key and effective role in controlling the symptoms of psoriasis.
Seyedhossein Jahanbakhsh, Arghavan Azizpoor, Maryam Nasimi, Amirhoushang Ehsani, Pedram Noormahamadpoor,
Volume 14, Issue 3 (11-2023)
Abstract
Background and Aim: The present study aims to assess the prevalence of obstructive sleep apnea in patients with psoriasis referring to Razi Hospital.
Methods: Participants were assessed for demographic characteristics, Psoriasis Area and Severity Index (PASI), disease duration, place of residence, education level, and were also evaluated using the Stop-Bang and Berlin questionnaires to assess the risk of obstructive sleep apnea. The high and low-risk groups for obstructive sleep apnea were compared regarding these parameters.
Results: Based on the Stop-Bang criteria, 43 individuals (41.3%) had moderate risk, and 23 individuals (22.1%) had high risk of obstructive sleep apnea. According to the Berlin questionnaire, 48 individuals (46.2%) were at high risk for obstructive sleep apnea. The mean age of individuals with high risk of obstructive sleep apnea according to the STOP-BANG criteria was significantly higher than those with moderate risk (mean=58.3, standard deviation=10.6, compared to mean=48.1, standard deviation=16.1, P = 0.039) and low risk (mean=41.7, standard deviation=17.8, P< 0.001). Additionally, BMI differed significantly among the three groups based on the Stop-BANG criteria, with higher BMI observed in individuals at higher risk for obstructive sleep apnea (P<0.05). BMI was significantly higher in individuals with high risk of obstructive sleep apnea according to the Berlin criteria compared to those with low risk (mean 31.1 versus mean 26, P<0.001).
Conclusion: The findings of this study highlight obstructive sleep apnea as a comorbidity associated with psoriasis.
Negar Asghari Hosori, Zeinab Bagheri,
Volume 15, Issue 2 (8-2024)
Abstract
The limitations of common needles in drug delivery, such as pain, infection, and side effects, have become a stimulus to search for more efficient alternatives. Meanwhile, microneedles have brought new hope in skin drug delivery. These microstructures are temporarily placed in the upper layers of the skin and provide a painless and non-invasive way for drugs to pass through the skin barrier. Diversity in the design and ingredients of microneedles allows the release of a wide range of drugs with high efficiency and low side effects. On the other hand, nanomedicines are proposed as an ideal alternative due to the limitations of traditional drugs and the need for more targeted and less detrimental options. Nanomedicines are new drug delivery systems that are designed and produced in nanometer dimensions. These small particles can carry and release drugs directly to the target cells with high precision and efficiency. By reducing side effects and increasing the effectiveness of treatment, nanomedicines can play a key role in improving the quality of treatment for various diseases. Considering the unique advantages of the combination of microneedles and nanomedicines, it is an important issue to investigate different strategies for using these new systems in drug release. In this article, this issue has been investigated as well as the applications of nanomedicine transfer by microneedle in the treatment of diseases and the upcoming challenges of this emerging technology.
Shahin Hamzelou, Fatemeh Jafari, Maryam Nasimi,
Volume 15, Issue 4 (2-2025)
Abstract
Background and aim: In the severe cases psoriasis, there is a need for biologic treatments which target the immunological responses contributing to the disease pathophysiology. There is no study in definite indications for the treatment choice and the time to start the biologic treatment in Iranian psoriasis patients.
Methods: We designed a cross-sectional study and evaluated all psoriasis patients who had received biologic treatment. After determining the patients who were eligible to participate in the study, their records were studied and analyzed.
Results: 50 patients with the mean age of 42.86 (SD=14.33) participated in the study. Twenty-five patients had received phototherapy for the treatment of psoriasis. All patients had received topical agents and 47 (94%) had received systemic treatment. Adalimumab was the most common biologic treatment used for the treatment of psoriasis patients (74%). 24% of patients had received Infliximab and 4% had received Etanercept.
Conclusion: 50 patients with the mean age of 42.86 (SD=14.33) participated in the study. Twenty-five patients had received phototherapy for the treatment of psoriasis. All patients had received topical agents and 47 (94%) had received systemic treatment. Adalimumab was the most common biologic treatment used for the treatment of psoriasis patients (74%). 24% of patients had received Infliximab and 4% had received Etanercept.
