Dermatology and Cosmetic
پوست و زیبایی
jdc
Medical Sciences
http://jdc.tums.ac.ir
1
admin
2008-7470
2228-7388
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fa
jalali
1401
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gregorian
2022
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مقایسه اثربخشی محلولهای موضعی والپروئیک اسید 8/3% و ماینوکسیدیل 5% در درمان ریزش موی آندروژنتیک
Comparison of the efficacy of valproic acid 8.3% and minoxidil 5% topical solutions in the treatment of androgenetic alopecia
تخصصي
Special
پژوهشي
Research
<span style="font-size:10pt"><span style="direction:rtl"><span style="unicode-bidi:embed"><span new="" roman="" style="font-family:" times=""><span bold="" class="AbstractBoldChar" new="" roman="" style="font-family:" times=""><span style="font-weight:bold"><span lang="AR-SA" style="font-size:11.0pt"><span b="" mitra="" style="font-family:">زمینه و هدف:</span></span></span></span><span lang="AR-SA" style="font-size:12.0pt"><span b="" mitra="" style="font-family:"> ریزش مو یکی از درگیریها و مشکلات رایج بین بیماریهای مرتبط با پوست و مو است. ریزش مو ممکن است منجربه اضطراب، افسردگی، کاهش عزتنفس و نارضایتی از ظاهر گردد.</span></span></span></span></span></span><br>
<span style="font-size:11pt"><span style="page-break-after:auto"><span style="line-height:6pt"><span style="direction:rtl"><span style="unicode-bidi:embed"><span new="" roman="" style="font-family:" times=""><span lang="AR-SA" style="font-size:13.0pt"><span style="font-family:"B Nazanin""></span></span></span></span></span></span></span></span><br>
<span style="font-size:10pt"><span style="page-break-after:auto"><span style="direction:rtl"><span style="unicode-bidi:embed"><span new="" roman="" style="font-family:" times=""><span bold="" class="AbstractBoldChar" new="" roman="" style="font-family:" times=""><span style="font-weight:bold"><span lang="AR-SA" style="font-size:11.0pt"><span b="" mitra="" style="font-family:">روش اجرا: </span></span></span></span><span lang="AR-SA" style="font-size:12.0pt"><span b="" mitra="" style="font-family:">بیماران با ریزش موی آندروژنتیک، درصورت داشتن شرایط، وارد مطالعه شدند. سپس این افراد بهصورت تصادفی به دو گروه تقسیم شدند. از شرکتکنندگان در تحقیق خواسته شد طبق پروتکل درمانی (روزی دو بار) بهطور تصادفی محلول والپروئیک اسید 3/8% یا محلول ماینوکسیدیل 5% را روی موضع دچار ریزش استعمال نمایند. بررسی موها در شروع مطالعه و 2 ماه بعد از درمان با استفاده از دستگاه </span></span>FotoFinder_trichoscale<span lang="AR-SA" style="font-size:12.0pt"><span b="" mitra="" style="font-family:"> صورت گرفت.</span></span></span></span></span></span></span><br>
<span style="font-size:11pt"><span style="page-break-after:auto"><span style="line-height:6pt"><span style="direction:rtl"><span style="unicode-bidi:embed"><span new="" roman="" style="font-family:" times=""><span lang="AR-SA" style="font-size:13.0pt"><span style="font-family:"B Nazanin""></span></span></span></span></span></span></span></span><br>
<span style="font-size:10pt"><span style="page-break-after:auto"><span style="direction:rtl"><span style="unicode-bidi:embed"><span new="" roman="" style="font-family:" times=""><span bold="" class="AbstractBoldChar" new="" roman="" style="font-family:" times=""><span style="font-weight:bold"><span lang="AR-SA" style="font-size:11.0pt"><span b="" mitra="" style="font-family:">یافتهها:</span></span></span></span><span lang="AR-SA" style="font-size:12.0pt"><span b="" mitra="" style="font-family:"> 2 ماه بعد از درمان در گروه</span></span> <span lang="AR-SA" style="font-size:12.0pt"><span b="" mitra="" style="font-family:">والپروئیک اسید در مقایسه با قبل از درمان، شاخص </span></span>anagen hair count<span style="font-size:12.0pt"><span b="" mitra="" style="font-family:"> (02/0</span></span><span class="AbstractItalicChar" style="font-family:SimSun"><span style="font-style:italic"><span dir="LTR" new="" roman="" style="font-family:" times="">P</span></span></span>=<span lang="AR-SA" style="font-size:12.0pt"><span b="" mitra="" style="font-family:">)، شاخص </span></span>general hair count<span style="font-size:12.0pt"><span b="" mitra="" style="font-family:"> (03/0</span></span><span class="AbstractItalicChar" style="font-family:SimSun"><span style="font-style:italic"><span dir="LTR" new="" roman="" style="font-family:" times="">P</span></span></span>=<span lang="AR-SA" style="font-size:12.0pt"><span b="" mitra="" style="font-family:">) و شاخص </span></span>terminal hair count<span style="font-size:12.0pt"><span b="" mitra="" style="font-family:"> (012/0</span></span><span class="AbstractItalicChar" style="font-family:SimSun"><span style="font-style:italic"><span dir="LTR" new="" roman="" style="font-family:" times="">P</span></span></span>=<span lang="AR-SA" style="font-size:12.0pt"><span b="" mitra="" style="font-family:">) تغییر معنیدار نشان دادند، درحالی که شاخص</span></span><br>
telogen hair count<span style="font-size:12.0pt"><span b="" mitra="" style="font-family:"> (059/0</span></span><span class="AbstractItalicChar" style="font-family:SimSun"><span style="font-style:italic"><span dir="LTR" new="" roman="" style="font-family:" times="">P</span></span></span>=<span lang="AR-SA" style="font-size:12.0pt"><span b="" mitra="" style="font-family:">) و </span></span>vellus hair count<span style="font-size:12.0pt"><span b="" mitra="" style="font-family:"> (097/0</span></span><span class="AbstractItalicChar" style="font-family:SimSun"><span style="font-style:italic"><span dir="LTR" new="" roman="" style="font-family:" times="">P</span></span></span>=<span lang="AR-SA" style="font-size:12.0pt"><span b="" mitra="" style="font-family:">) تغییر معنیداری نشان نداد. این تغییرات در گروه مانوکسیدیل بیشتر بود.</span></span></span></span></span></span></span><br>
<span style="font-size:11pt"><span style="page-break-after:auto"><span style="line-height:6pt"><span style="direction:rtl"><span style="unicode-bidi:embed"><span new="" roman="" style="font-family:" times=""><span lang="AR-SA" style="font-size:13.0pt"><span style="font-family:"B Nazanin""></span></span></span></span></span></span></span></span><br>
<span bold="" class="AbstractBoldChar" new="" roman="" style="font-family:" times=""><span style="font-weight:bold"><span dir="RTL" lang="AR-SA" style="font-size:11.0pt"><span b="" mitra="" style="font-family:">نتیجهگیری:</span></span></span></span><span dir="RTL" lang="AR-SA" style="font-size:13.0pt"><span b="" nazanin="" style="font-family:"> محلول والپروئیک اسید 3/8 درصد میتواند در افزایش تعداد مو و کاهش درصد موهای تلوژن اثرات مثبتی نشان دهد. بهعلت مکانیسم تأخیری والپروئیک اسید، طول مدت درمان با این ترکیب میبایست بیشتر از ماینوکسیدیل بهعنوان کنترل مثبت درنظر گرفته شود.</span></span>
<p><span style="font-size:11pt"><span style="line-height:110%"><span new="" roman="" style="font-family:" times=""><span bold="" class="NormalLeftBoldChar" new="" roman="" style="font-family:" times=""><span style="font-weight:bold">Background and Aim:</span></span> Hair loss is one of the most common problems among the skin and hair related diseases. Hair loss can lead to anxiety, depression, low self-esteem and dissatisfaction with appearance.</span></span></span><br>
</p>
<p><span style="font-size:11pt"><span style="line-height:110%"><span new="" roman="" style="font-family:" times=""><span bold="" class="NormalLeftBoldChar" new="" roman="" style="font-family:" times=""><span style="font-weight:bold">Methods:</span></span> Patients with androgenetic alopecia who met the eligibility criteria entered the study. Participants were asked to randomly apply a solution of valproic acid 8.3% or a solution of minoxidil 5% on the affected areas according to the treatment protocol (twice a day). Before and 2 months after treatment, the participants were evaluated. The studied indices included the number of hair follicles in the specified area, the number of velus hairs, the number of terminal hairs, the average hair thickness, and the percentage of hairs in the anagen and telogen phases, as well as the skin reactions in the area. Hairs were examined at the beginning of the study and at 2 months after treatment using Foto Finder-trichoscale device.</span></span></span><br>
</p>
<p><span style="font-size:11pt"><span style="line-height:110%"><span new="" roman="" style="font-family:" times=""><span bold="" class="NormalLeftBoldChar" new="" roman="" style="font-family:" times=""><span style="font-weight:bold">Results:</span></span> Two months after treatment compared to baseline in the valproic group, anagen hair count index (<span b="" class="NormalLeftItalicChar" nazanin="" style="font-family:"><span style="font-style:italic"><span new="" roman="" style="font-family:" times="">P</span></span></span>=0.02), general hair count index (<span b="" class="NormalLeftItalicChar" nazanin="" style="font-family:"><span style="font-style:italic"><span new="" roman="" style="font-family:" times="">P</span></span></span>=0.03), and terminl hair count index (<span b="" class="NormalLeftItalicChar" nazanin="" style="font-family:"><span style="font-style:italic"><span new="" roman="" style="font-family:" times="">P</span></span></span>=0.012) showed significant changes. While telogen hair count (<span b="" class="NormalLeftItalicChar" nazanin="" style="font-family:"><span style="font-style:italic"><span new="" roman="" style="font-family:" times="">P</span></span></span>=0.059) and vellus hair count (<span b="" class="NormalLeftItalicChar" nazanin="" style="font-family:"><span style="font-style:italic"><span new="" roman="" style="font-family:" times="">P</span></span></span>=0.097) did not show significant changes. These changes were more significated in minoxidil group.</span></span></span></p>
<p><br>
<span bold="" class="NormalLeftBoldChar" new="" roman="" style="font-family:" times=""><span style="font-weight:bold"><span style="font-size:11.0pt">Conclusion:</span></span></span><span style="font-size:11.0pt"><span new="" roman="" style="font-family:" times=""> 8.3% valproic acid solution showed positive effects in increasing the number of hairs and decreasing the percentage of telogen hairs. Due to the delayed mechanism of valproic acid, the duration of treatment with this compound should be considered longer than minoxidil as a positive control.</span></span></p>
والپروئیک اسید, ریزش موی آندروژنتیک, محلول موضعی, الگوی ریزش موی مردانه
valproic acid, androgenetic alopecia, topical solution, male pattern hair loss
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http://jdc.tums.ac.ir/browse.php?a_code=A-10-1-289&slc_lang=fa&sid=1
Azin
Ayatollahi
آذین
آیتالهی