Dermatology and Cosmetic
پوست و زیبایی
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Medical Sciences
http://jdc.tums.ac.ir
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2008-7470
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2024
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نقش RNA بلند غیرکدکننده در پاتوژنز، پیشآگهی و درمان سرطان پوست غیرملانومی
The role of incRNAs in pathogenesis, prognosis and treatment of non-melanoma skin cancer
عمومى
General
مروري
Review
<span style="font-size:10pt"><span style="direction:rtl"><span style="unicode-bidi:embed"><span new="" roman="" style="font-family:" times=""><span lang="AR-SA" style="font-size:12.0pt"><span b="" mitra="" style="font-family:">اختلال در تنظیم </span></span>RNA<span lang="AR-SA" style="font-size:12.0pt"><span b="" mitra="" style="font-family:"> بلند غیرکدکننده ممکن است منجر به بیماریهای مختلفی ازجمله سرطان شود. اخیراً بسیاری از </span></span>lincRNA<span lang="AR-SA" style="font-size:12.0pt"><span b="" mitra="" style="font-family:">ها بهدلیل نقش مهمشان در ملانوم، </span></span>Cutaneous Squamous Cell Carcinoma (CSCC)<span lang="AR-SA" style="font-size:12.0pt"><span b="" mitra="" style="font-family:"> و </span></span>Basal Cell Carcinoma (BCC)<span lang="AR-SA" style="font-size:12.0pt"><span b="" mitra="" style="font-family:"> کشف شدهاند. این </span></span>RNA<span lang="AR-SA" style="font-size:12.0pt"><span b="" mitra="" style="font-family:"> بلند غیرکدکننده در تکثیر سلولهای سرطانی پوست، رگزایی، تهاجم و متاستاز نقش دارند. </span></span></span></span></span></span><br>
<span style="font-size:10pt"><span style="direction:rtl"><span style="unicode-bidi:embed"><span new="" roman="" style="font-family:" times=""><span lang="AR-SA" style="font-size:12.0pt"><span b="" mitra="" style="font-family:">برخی از </span></span>RNA<span lang="AR-SA" style="font-size:12.0pt"><span b="" mitra="" style="font-family:">های بلند غیرکدکننده وجود دارند که در </span></span>Nonmelanoma Skin Cancer (NMSC)<span lang="AR-SA" style="font-size:12.0pt"><span b="" mitra="" style="font-family:"> تنظیم مثبتی دارند؛ از جمله </span></span>PICSAR<span lang="AR-SA" style="font-size:12.0pt"><span b="" mitra="" style="font-family:">، </span></span>PRECSIT<span lang="AR-SA" style="font-size:12.0pt"><span b="" mitra="" style="font-family:">، </span></span>LINC01048<span lang="AR-SA" style="font-size:12.0pt"><span b="" mitra="" style="font-family:">، </span></span>MALAT1<span lang="AR-SA" style="font-size:12.0pt"><span b="" mitra="" style="font-family:">، </span></span>LINC00319<span lang="AR-SA" style="font-size:12.0pt"><span b="" mitra="" style="font-family:">، </span></span>AK144841<span lang="AR-SA" style="font-size:12.0pt"><span b="" mitra="" style="font-family:"> در </span></span>SCC<span lang="AR-SA" style="font-size:12.0pt"><span b="" mitra="" style="font-family:"> و </span></span>H19<span lang="AR-SA" style="font-size:12.0pt"><span b="" mitra="" style="font-family:">، </span></span>CASC15<span lang="AR-SA" style="font-size:12.0pt"><span b="" mitra="" style="font-family:"> و </span></span>SPRY4-IT<span lang="AR-SA" style="font-size:12.0pt"><span b="" mitra="" style="font-family:"> در </span></span>BCC<span lang="AR-SA" style="font-size:12.0pt"><span b="" mitra="" style="font-family:">. در مقابل، برخی از </span></span>RNA<span lang="AR-SA" style="font-size:12.0pt"><span b="" mitra="" style="font-family:"> بلند غیرکدکننده وجود دارند که در </span></span>SCC<span lang="AR-SA" style="font-size:12.0pt"><span b="" mitra="" style="font-family:"> تنظیم منفی میکنند؛ ازجمله </span></span>TINCR<span lang="AR-SA" style="font-size:12.0pt"><span b="" mitra="" style="font-family:">، </span></span>SMRT-2<span lang="AR-SA" style="font-size:12.0pt"><span b="" mitra="" style="font-family:"> و </span></span>LINC00520<span lang="AR-SA" style="font-size:12.0pt"><span b="" mitra="" style="font-family:">.</span></span></span></span></span></span><br>
<span style="font-size:10pt"><span style="page-break-after:auto"><span style="direction:rtl"><span style="unicode-bidi:embed"><span new="" roman="" style="font-family:" times=""><span lang="AR-SA" style="font-size:12.0pt"><span b="" mitra="" style="font-family:">بسیاری از </span></span>RNA<span lang="AR-SA" style="font-size:12.0pt"><span b="" mitra="" style="font-family:"> غیرکدکنندهها بهطور خاص در برخی بافتها یا سلولها بیان میشوند و برخی دیگر با مرحلهبندی تومور، مقاومت دارویی و پیشآگهی ارتباط دارند ازاینرو، </span></span>RNA<span lang="AR-SA" style="font-size:12.0pt"><span b="" mitra="" style="font-family:"> غیرکدکننده میتواند بهعنوان ابزارهای تشخیصی و پیشآگهی در سرطانهای پوست استفاده شود.</span></span><span lang="FA" style="font-size:12.0pt"><span style="font-family:"B Mitra""></span></span></span></span></span></span></span><br>
<div><span style="font-size:11pt"><span style="line-height:110%"><span new="" roman="" style="font-family:" times="">Dysregulation of long non-coding RNA may lead to various diseases including cancer. Recently, many lincRNAs have been discovered for their important roles in melanoma, cutaneous squamous cell carcinoma (SCC), and basal cell carcinoma (BCC). These long non-coding RNAs are involved in skin cancer cell proliferation, angiogenesis, invasion, and metastasis.</span></span></span><br>
<span style="font-size:11pt"><span style="line-height:110%"><span new="" roman="" style="font-family:" times="">Some long non-coding RNAs are upregulated in Non-melanoma Skin Cancer (NMSC), including PICSAR, PRECSIT, LINC01048, MALAT1, LINC00319, AK144841 in SCC and H19, CASC15, SPRY4-IT in BCC. In contrast, some long non-coding RNAs are down-regulated in SCC, including TINCR, SMRT-2, and LINC00520.</span></span></span><br>
<span style="font-size:11pt"><span style="line-height:110%"><span new="" roman="" style="font-family:" times="">Many non-coding RNAs are specifically expressed in certain tissues or cells, and others are associated with tumor staging, drug resistance, and prognosis. Hence, non-coding RNAs can be used as diagnostic and prognostic tools in skin cancers.</span></span></span></div>
RNA بلند غیرکدکننده, سرطان پوست غیرملانومی, BCC, SCC
non-coding rnas, non-melanoma skin cancer, bcc, scc
231
242
http://jdc.tums.ac.ir/browse.php?a_code=A-10-1-350&slc_lang=fa&sid=1
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Tamimi
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تمیمی
Pegahtamimi.md@gmail.com