Journal of Dental Medicine

Assessment of relationship between maxillary and mandibular base length and dental crowding in individuals with different sagittal skeletal patterns in northern Iran

niki

Background and Aims: Dental crowding is considered a significant factor in the development of malocclusion. Identifying the factors contributing to its formation aids in selecting appropriate treatment strategies and achieving stable post-treatment results. Since the relationship between jaw base length and this factor remains unclear, the objective of this study was to investigate the association between the jaw base length and dental crowding in individuals with different skeletal patterns in the sagittal dimensio in north of Iran.
Materials and Methods: In this cross-sectional study, 42 individuals from each skeletal class (I, II, and III) were enrolled based on crowding of >4 mm and ≤4 mm, selected through census from all patients referred to the Orthodontic Department of Babol Dental School (Iran) between 2011 and 2025. These samples were examined for the association between jaw base length in each skeletal classification and dental crowding. Lateral cephalograms from before treatment were used to measure the jaw base length. T-tests, one-way ANOVA, and Bonferroni post hoc tests were employed to examine the desired associations, with a significance level of 0.05.
Results: A total of 126 patients (64.3% female) were evaluated. The relationship between jaw base length and crowding was not significant with respect to age, but it was reported as significant in females in the mandible (P=0.024). The present study indicated that the length of the maxillary and mandibular bases in the entire sample did not show a direct and significant correlation with the degree of dental crowding. However, subgroup analysis based on skeletal classes revealed significant differences in maxillary and mandibular base lengths between skeletal classes I, II, and III at both crowding levels (≤4 mm and >4 mm) (P=0.008, 0.011, and P<0.001, respectively). In the mandible, class III had the greatest length and class II had the shortest. In the maxilla, class III had the shortest length and class II had the greatest.
Conclusion: These findings suggest that sagittal skeletal patterns play a significant role in the dimensional changes of the jaws. Furthermore, in classes I and III, examining the mandibular base length is more important, as its reduction may be associated with more severe crowding. The maxillary and mandibular base lengths in the entire sample did not exhibit a direct and significant correlation with the severity of dental crowding. These variables were not significant with respect to age but were reported as significant in females in the mandible. Therefore, a single anatomical index like base length cannot solely predict the severity of crowding.

Application of plant-derived polyphenolic compounds in dental materials: Functional modulators for durability, biocompatibility, and biofilm control

Babak Akbari

This narrative review provides a comprehensive overview of the potential of plant-derived polyphenols in restorative and preventive dentistry. As natural bioactive compounds such as polyphenols reshape the oral microbial ecology by attenuating virulence, inhibiting quorum-sensing communication, disrupting extracellular polymeric substance (EPS) formation, and reducing acidogenicity within dental biofilms. Beyond their antimicrobial effects, polyphenols can protect host tissues, namely, enamel, dentin, and gingiva, by cross-linking collagen fibrils, suppressing matrix metalloproteinase (MMP) activity, and modulating inflammatory pathways. Experimental, in situ, and clinical evidence consistently demonstrated improved bond durability at the dentin–resin interface. The most compelling data support the use of primers containing proanthocyanidins, quercetin, epigallocatechin gallate (EGCG), and resveratrol. In preventive applications, catechin-based varnishes have demonstrated remineralization effects comparable to those of fluoride varnishes. Conversely, pomegranate extract–enriched mouthrinses, in the presence of fluoride, could enhance both anti-demineralization and antibiofilm activity. In the context of implants and dental prostheses, the polyphenol-functionalized coatings, particularly those based on tannic or caffeic acid, would reduce biofilm formation and provide corrosion resistance for metallic surfaces. Nevertheless, several formulation challenges remain, including rapid oxidation, limited solubility, and discoloration, all of which require careful management. Strategies such as dose optimization, solvent selection, covalent stabilization, and microencapsulation are recommended to overcome these limitations. For broader and more effective clinical translation, standardization of multispecies laboratory models and harmonization of clinical endpoints are essential. Furthermore, future longitudinal trials are needed to bridge the gap between laboratory findings and clinical performance. Ultimately, with the design of innovative delivery systems and long-term monitoring of parameters such as restoration survival, secondary caries, periodontal health, and color stability, polyphenols hold promise to define a new generation of antibacterial, biocompatible, and aesthetically stable dental materials.

Evaluation of the effect of tranexamic acid with Gelfoam carrier in preventing dry socket syndrome following surgical removal of impacted mandibular third molars

Masoud Hassanzadeh

Background and Aims: Dry socket is one of the most common complications following dental surgery. Therefore, effective prevention of dry socket can significantly improve patient recovery after tooth extraction. The aim of this study was to evaluate the effect of tranexamic acid combined with a Gelfoam carrier on the prevention of dry socket following surgical removal of impacted mandibular third molars.
Materials and Methods: This parallel randomized clinical trial was conducted in 2023 on 72 patients (40 in the intervention group and 32 in the control group) at the Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, Islamic Azad University, Tehran Unit. In the intervention group, 250 mg of tranexamic acid powder was placed into the extraction socket and covered with Gelfoam, whereas the control group received sterile gauze only. The diagnosis of dry socket was made 2–3 days postoperatively by an independent surgeon. Statistical analysis was performed using the chi-square test, likelihood ratio, and Fisher’s exact test, with a significance level set at P<0.05.
Results: The incidence of dry socket was 7.5% in the intervention group and 34.4% in the control group. All statistical tests demonstrated a significant reduction in the occurrence of dry socket in the intervention group (P≤0.005). These findings are consistent with the physiological mechanism of tranexamic acid in inhibiting fibrinolysis and stabilizing the blood clot, resulting in a marked reduction compared with the control group.
Conclusion: Topical application of the tranexamic acid in combination with Gelfoam following extraction of impacted third molars is an effective, simple, and cost-effective method for the prevention of dry socket. For broader clinical recommendation, further studies with larger sample sizes, comparisons with existing standard preventive methods, and longer follow-up periods are suggested.

Survey of the level of awareness of parents of 6-12-year-old children in Khorramabad schools about fissure sealants in the academic year 2021

Samad Darabian

Background and Aims: Many oral health problems, including tooth decay mostly begin in childhood. Since decay in pits and fissures accounts for a higher percentage, it is of great importance to expand fissure sealant therapy, raise awareness and parents' attitudes towards preventive methods, especially fluoride and fissure sealant therapy. Therefore, the aim of the present study was to evaluate the awareness of parents of 6-12 year old children in Khorramabad city in Iran about the fissure sealant method for preventing tooth decay.
Materials and Methods: The present study was descriptive-analytical. In this study, 601 parents of 6-12 year old children in Khorramabad schools were evaluated using cluster sampling in the academic year 2021. The designed questionnaire included demographic information and questions that estimated the level of parental awareness about fissure sealants. Then, data were analyzed by the SPSS version 23 software and Pearson correlation, ANOVA, and T-test statistical tests.
Results: The mean age of the participants was 40.54 ± 8.09. 339 of the subjects had a bachelor's degree or higher. 17.3% of parents had a good level of knowledge. In this study, a statistically significant relationship was observed between the knowledge score and the variables of education level (P<0.02), oral hygiene education history (P<0.001), and time of visiting the dentist (P<0.05). However, no significant relationship was observed between the age, parental relationship, and economic status (P>0.05).
Conclusion: The findings of this study showed that the awareness score of most of the individuals participated in the study was low about fissure sealants, especially in the individuals with low level of education or no education. Therefore, more attention and serious attempts should be done to increase the parental awareness in this regard.

An investigation of the impact of oral health in children under six years old on family quality of life and its associated factors in Qazvin city, 2022

Razie Hosseininavaz

Background and Aims: Oral health is recognized as an integral component of general health andlike other health aspects, can significantly impact the quality of life of both the individual and their family. Due to their rapid physical and psychological development, children are particularly vulnerable to the adverse consequences of oral health problems. Accordingly, the present study aimed to investigate the impact of children's oral health on family quality of life and the factors influencing this relationship among children under six years old in Qazvin, Iran.
Materials and Methods: This cross-sectional study was conducted on the parents of 80 six-year-old children in Qazvin city in 2022. A convenience sampling method was employed, recruiting participants from among those attending the Dental School of Qazvin University of Medical Sciences. Initially, the child's demographic information (age, gender, birth order, and family socioeconomic status) was collected from the parents. Subsequently, they completed the Family Impact Scale (FIS) questionnaire. This questionnaire assesses the impact of a child's oral and dental problems on the family, utilizing four subscales. Subsequently, questions were asked regarding general health, oral and dental health, dental visits, and the services received. The collected data were then analyzed using descriptive and analytical statistics including variance, Pearson correlation, and T tests.
Results: 80 parents were enrolled in the study of whom 39 had a son and 41 had a daughter. The mean age of the studied children was 4.72±1.06 years, with an age range of 3 years (the youngest being 3 and the oldest 6 years old). Among the dimensions of family quality of life (FIS), the family finances subscale had the highest mean score (0.53 ± 0.68), while the family conflict subscale had the lowest (0.73±0.44). The overall mean score for family quality of life was 0.52±0.6. No statistically significant relationship was found between the outcome variable (oral health-related quality of life) and the independent variable of family economic status (P>0.05). However, a statistically significant relationship was observed with the independent variable of the child's birth order (P=0.002), indicating that the impact of the child's oral health on family quality of life would increase with a higher birth order. Furthermore, a significant relationship was found between the child's age and two subscales of family quality of life: family activity (P=0.03) and family conflict (P=0.006). Specifically, a younger child's age was associated with a greater impact of their oral health on the family's quality of life. There was a significant relationship between the child's general health and oral/dental health from the parents' perspective and the impact of the obtained FIS score (P=0.001 and P=0.04, respectively).
Conclusion: The findings indicated that a child's oral health status could impact the family quality of life, and this impact was associated with the child's age and birth order.

Investigation of the prevalence of missed MB2 canals in root canal-treated maxillary first molars using CBCT in patients referred to Borujerd dental school (2014-2018)

Hiva Ebrahimi

Occurrence of ameloblastoma in an old man in an unexpected site: A case report

kimia mashayekh

Ameloblastoma is one of the most common benign tumors originating from odontogenic tissues. Despite being benign, it has a locally aggressive behavior and a high tendency to relapse. While, this tumor is mainly found in the posterior region of the mandible, its occurrence in the maxilla is rare and is associated with more diagnostic and therapeutic challenges. This report presents a rare case of ameloblastoma in the maxilla of a 64-year-old male patient who presented with painless swelling and significant extension of the lesion to the midpalate. Clinical, radiological, and histopathological findings were reviewed and after necessary evaluations, the diagnosis of ameloblastoma was confirmed. The anatomical complexity of the maxilla, proximity to vital structures, and surgical limitations make the management of these tumors more difficult. The present report emphasizes the importance of early diagnosis, careful histological examination, and the need for a multidisciplinary therapeutic approach in dealing with this type of tumor.

Awareness, performance and oral health behaviors among pharmacists and pharmacy staff in Isfahan regarding oral health

Background and Aims: Pharmacies can serve as an appropriate setting for the provision of oral health care, including preventive services, early detection, and referrals. The present study aimed to assess the awareness, performance and oral health behaviors as well as self-perceived oral health among pharmacists and pharmacy staff in Isfahan.
Materials and Methods: This cross-sectional study was conducted in 2024 using a random sampling method across pharmacies in Isfahan. In total, 176 pharmacists and pharmacy staff completed a standard self-administered questionnaire in person, regarding their awareness, performance, and behaviors related to oral health, as well as their self- perceived oral health. Data were analyzed using Chi-square test, Mann–Whitney U test, and Spearman correlation coefficient in SPSS software version 27 (P<0.05).
Results: Oral health knowledge was rated as poor in 34 individuals (19.3%), moderate in 89 (50.6%), and good in 53 (30.1%). Pharmacists’ knowledge score was significantly higher than that of other pharmacy staff (P=0.002). The most commonly reported service provided to clients by participants was offering analgesics for pain relief (61.9%). While, less than half of the participants reported providing information on oral hygiene (36.9%) or referring clients to a dentist (40.9%). Oral health behaviors including brushing teeth at least twice a day (80.4%), regular use of fluoride toothpaste (97.2%), visiting a dentist during the past year (55.1%), and non smoking (67.0%) were favorable among most participants. However, flossing (50.6%) and frequent snacking (65.3%) were unfavorable in majority of individuals.
Conclusion: Considering the moderate level of oral health knowledge and the presence of some unfavorable behaviors such as insufficient use of dental floss and frequent snacking, it is recommended to implement educational programs to improve knowledge and promote positive oral health behaviors

Assessment of anterior and overall Bolton ratios in various vertical skeletal patterns in population from northern Iran

Reza Faraji

Background and Aims: Bolton ratios—the anterior and overall ratios—are important indicators for assessing the dental proportionality between the maxilla and mandible, playing a crucial role in achieving ideal occlusion and successful orthodontic outcomes. Given individual variations in facial growth patterns and their potential influence on these ratios, the present study aimed to evaluate the relationship between Bolton ratios and vertical skeletal patterns in the population from northern Iran, as well as to investigate the effect of gender on these ratios.
Materials and Methods: In this observational-analytical study, 173 Class I orthodontic patients
(121 females and 52 males) with a mean age of 16.02 ± 4.51 years were evaluated. Based on the vertical facial pattern using the Jarabak index, the subjects were categorized into three groups: short face (n=52), normal face (n=67), and long face (n=54). The anterior and overall Bolton ratios, and overbite were measured from dental casts. Data were analyzed using Chi-square, ANOVA, t-test, and Pearson’s correlation coefficient in SPSS ver. 26, with a significance level set at 0.05.
Results: No statistically significant differences were found in the anterior and overall Bolton ratios among the three vertical facial groups (P=0.062 and P=0.36, respectively) or between genders (P=0.53 and P=0.42, respectively). In contrast, the mean overbite significantly differed among the groups (P<0.001). Comparison of the anterior (79.16 ± 3.88%) and overall (90.09 ± 6.89%) Bolton ratios with the original Bolton standards revealed statistically significant differences (P=0.001 and P=0.02, respectively).
Conclusion: According to the findings, neither the vertical skeletal pattern nor gender had a significant effect on Bolton ratios. Nevertheless, the observed differences between the ratios in this northern Iranian population and the original Bolton standards underscore the importance of using population-specific norms in orthodontic treatment planning.

Detection of SARS-CoV-2 RNA in aerosols of clinical and non-clinical areas of a dental clinic during the post-pandemic period

Seyed Hamed Mirhoseini

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Background and Aims: The SARS-CoV-2 virus, capable of airborne transmission through aerosols, poses a significant challenge in clinical settings such as dental clinics. The use of high-speed instruments, including handpieces and ultrasonic scalers, generates considerable aerosols that, if contaminated, may facilitate infection transmission. This study aimed to detect the presence of the SARS-CoV-2 virus in the clinical and non-clinical areas of a dental clinic.

Materials and Methods: In this cross-sectional study, 20 air samples were collected from various sections of the Dental School of Arak University of Medical Sciences. Sampling was performed using a pump equipped with a filter for two hours at a flow rate of 5 L/min and a height of 1.5 m above the floor. The samples were transported under a cold chain, the viral RNA was extracted, and then were analyzed using a specific RT-PCR kit.

Results: Out of 20 collected air samples, 3 samples (15%) tested positive for SARS-CoV-2 RNA. Two from clinical departments (restorative and fixed prosthodontics) and one from a non-clinical area
(pre-clinic).

Conclusion: The findings of this study indicated that SARS-CoV-2 RNA was detectable in some air samples from both clinical and non-clinical areas of the dental clinic. These results highlight the importance of strict adherence to infection control protocols across all sections of dental clinics to minimize the risk of airborne transmission.

Prevalence of ponticulus posticus in different skeletal malocclusions types in population from northern Iran

Reza Faraji

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Background and Aims: Ponticulus posticus is a bony anomaly in the atlas vertebra that may have significant clinical implications, particularly when extreme head movements are required during treatment. The present study aimed to evaluate the prevalence of ponticulus posticus in different types of skeletal malocclusions in the population from northern Iran.

Materials and Methods: In this observational-analytical study, 246 lateral cephalometric radiographs of eligible individuals referred to two oral and maxillofacial radiology centers in Babol, northern Iran, in 2021, were included using convenience sampling and evaluated. Skeletal classification was determined using the ANB angle and Wits analysis. The presence of ponticulus posticus was evaluated across different skeletal classes, genders, and age groups. Data were analyzed using the Chi-square test in SPSS software with a significance level set at 0.05.

Results: Among the total sample, ponticulus posticus was observed in 104 cases (42.3%), of which 62 cases (25.2%) were of the partial type and 42 cases (17.1%) were of the complete type. The prevalence of this anomaly was significantly higher in males than in females (P<0.001). However, there was no statistically significant association between the presence of ponticulus posticus and skeletal class (P=0.222) or age group (P=0.483).

Conclusion: The findings of the present study indicated that ponticulus posticus was a relatively common anomaly, with a higher prevalence in males, and therefore should be taken into consideration. However, this anomaly neither appear to be a result of age-related calcification, nor can be used as a predictive indicator for determining skeletal class type.

Evaluation of the prevalence of root resorption in teeth adjacent to impacted maxillary canines using cone-beam computed tomography

Reza Faraji

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Background and Aims: Root resorption of teeth adjacent to impacted canines, although relatively uncommon, is a potentially harmful condition that may lead to tooth loss. Early diagnosis and the use of accurate imaging techniques play a crucial role in preventing from root resorption complications. This study aimed to evaluate the prevalence of root resorption in teeth adjacent to impacted maxillary canines using cone-beam computed tomography (CBCT) images.

Materials and Methods: In this retrospective observational-analytical study, 60 CBCT images of patients with impacted maxillary canines (15 bilateral case and 45 unilateral cases) were examined using a convenience sampling method among those referred to oral and maxillofacial radiology clinics in northern Iran, Babol, in 2023. Variables such as age, gender, position and direction of canine eruption, presence of root resorption in adjacent teeth, type of affected tooth, severity, and location of resorption were evaluated. Data were analyzed using the chi-square test in SPSS software at a significance level of 0.05.

Results: Among the studied CBCT (66.7% female; 70% over 18 years of age), 75 cases of impaction (41 cases on the right and 34 cases on the left) were observed. Root resorption in the teeth adjacent to the impacted maxillary canines was observed in only 7 patients (11.7%). All resorptions were mild and observed in the lateral incisors. In terms of vertical position, 85.7% of the cases occurred in the middle third of the root. There was no statistically significant association between root resorption and gender, age, or the position or direction of canine eruption (P>0.05).

Conclusion: Given the potential for root resorption in lateral incisors and in the middle third of the root, it is recommended that oral and maxillofacial surgeons and orthodontists perform a thorough initial evaluation of the canine’s position and adjacent teeth using CBCT imaging prior to treatment to prevent possible complications.

The effect of first premolar extractions on overall and anterior Bolton ratios in patients with bimaxillary dentoalveolar protrusion

Reza Faraji

Background and Aims: Bimaxillary dentoalveolar protrusion (BDP) is a common orthodontic anomaly characterized by protrusive dental arches and lip prominence. Extraction of the first premolars is a frequently employed treatment approach in these patients. However, the effect of this intervention on Bolton ratios-particularly the overall and anterior ratios-remains unclear. This study aimed to evaluate the impact of first premolar extractions on Bolton ratios in patients with BDP.
Materials and Methods: This experimental study was conducted on archived physical models of 34 Class I patients with BDP and functional lip incompetency (>4 mm) accompanied by lip protrusion, available at the Orthodontics Department of School of Dentistry, Babol, in 2024. All patients had a full complement of teeth from the first incisor to the first molar in each quadrant. After digitizing the models, mesiodistal tooth widths and the overall and anterior Bolton ratios were calculated. Digital simulation of first premolar extraction was performed, followed by reassessment of Bolton ratios. Pre- and post-treatment values were statistically compared using paired t-tests in SPSS (significance level set at 0.05).
Results: Among 34 studied casts, 67.6 % belonged to females. The mean overall Bolton ratio decreased significantly from 90.33 ± 2.23% to 87.72 ± 2.39%, and the anterior ratio declined from 78.19 ± 2.96% to 77.85 ± 3.03% (P<0.001). Additionally, 15 patients exhibited residual space post-treatment, primarily in the mandibular arch.
Conclusion: Based on the results of the present study, first premolar extraction significantly reduced both the overall and anterior Bolton ratios in patients with bimaxillary dentoalveolar protrusion. However, the likelihood of residual space—particularly in the lower arch-should be carefully considered during orthodontic treatment planning to ensure long-term stability and success.

Comparison of the effects of different adhesive systems on the bond strength of repaired composite restorations

Solmaz Charmi

Background and Aims: Repairing existing composite restorations, rather than replacing them entirely, is regarded as a conservative and tissue-preserving approach in restorative dentistry. However, achieving a durable bond between the aged and newly applied composite resin remains a significant clinical challenge. This study aimed to compare the shear bond strength of repaired composite restorations using three different adhesive systems.
Materials and Methods: In this in vitro study, which conducted at the Faculty of Dentistry, Urmia University of Medical Sciences, 60 disk-shaped composite specimens were fabricated with standard dimensions. After undergoing artificial aging (storage in distilled water for 6 months), their surfaces were roughened mechanically using a diamond bur. The specimens were randomly divided into three groups (n=20) and repaired using fifth-generation (Adper Single Bond), seventh-generation (OptiBond All-In-One), and universal (Single Bond Universal) adhesives, followed by the application of new composite. All specimens were subjected to thermocycling, and the shear bond strength was measured using a universal testing machine. Fracture patterns of the samples were also examined using a stereomicroscope to determine the modes of failure. Data were analyzed using one-way ANOVA and Chi-square tests in SPSS at a significance level of 0.05.
Results: The mean shear bond strengths were 15.22 ± 4.47 MPa for Adper Single Bond, 14.05 ± 4.66 MPa for OptiBond All-In-One, and 13.44 ± 4.68 MPa for Single Bond Universal. No statistically significant differences were found among the groups (P=0.468). Fracture pattern distribution was also not significantly different (P=0.453), with predominantly cohesive or mixed failures observed across all groups. No adhesive failures were observed.
Conclusion: Under standardized surface preparation, none of the tested adhesive systems demonstrated a statistically significant advantage in the shear bond strength between the aged and new composite. Therefore, the choice of adhesive in composite repair procedures can be guided by practical considerations such as product availability, ease of application, and dentist preference.

Prevalence of work-related musculoskeletal disorders among dentists in Babol

Meisam Moradi

Background and Aims: Musculoskeletal disorders (MSDs) are among the most common occupational health problems faced by dentists. Given their impact on dentists’ health and performance, the present study aimed to investigate the prevalence of MSDs among general and specialist dentists practicing in Babol, Iran.
Materials and Methods: In this cross-sectional study, the standardized Nordic questionnaire, consisting of general and specific sections, was distributed in person among dentists practicing in Babol, based on data obtained from the local Medical Council. Distribution was carried out after a telephone invitation and confirmation of willingness to participate. The questionnaire included items regarding pain and discomfort in different body regions such as the neck, shoulders, and lower back. The frequency of participants with MSDs was assessed based on gender, right/left handedness, specialty, playing sports, and participating in a specific sport. The mean age, weight, height, body mass index, weekly working hours, and work experience of dentists with and without MSDs were also compared. Data were analyzed using SPSS software version 22, employing independent t-tests, Chi-square tests, and Fisher’s exact test, with a significance level set at 0.05.
Results: Of the 182 dentists approached, 17 declined participation and 5 met the exclusion criteria. A total of 160 dentists (mean work experience: 15.65 ±9.26 years) were included in the study; of these, 100 (62.5%) were male, 95 (59.4%) were general practitioners, and 65 (40.6%) were specialists. The overall prevalence of MSDs in this population was reported to be 90%. The most commonly affected region was the neck (76.4%), while the least affected was the ankle (3%). A statistically significant association was found between engaging in a specific type of regular physical activity and a reduced incidence of MSDs (P<0.001). No significant associations were observed with other variables such as gender, handedness, specialty, or field of specialization (P>0.05). Furthermore, no significant differences were found in the mean height, weight, body mass index, weekly working hours, or years of experience between dentists with and without MSDs (P>0.05).
Conclusion: Musculoskeletal disorders are highly prevalent among dentists in Babol. Given this high prevalence, the development and implementation of educational programs on ergonomics, along with recommendations for targeted physical activity appear to be essential.

Evaluation of the anti-viral effects of combinations of cetylpyridinium chloride and nano-silver colloid on herpes simplex virus type 1

Elaheh Beyabanaki

Background and Aims: Despite documentation on the antiviral effects of cetylpyridinium chloride (CPC) and nano-silver colloid (Ag) on herpes simplex virus type 1, the synergistic effect of these two materials at different concentrations is unknown. This study aimed to evaluate the antiviral effect of various concentration combinations of cetylpyridinium chloride and nano-silver colloid on herpes simplex virus type 1.
Materials and Methods: This laboratory study conducted at the molecular virology department of Iran Pasteur Institute in the year 1400. After testing the cytotoxicity of different concentrations of CPC and Ag, the disinfecting effect of safe concentrations of each substance individually and also in the form of three compounds, was examined on the cells infected with herpes simplex virus type 1. The study groups included groups 1 to 6 with 0.01 µg/ml to 1000 µg/ml of Ag, groups 7 to 12 with 0.1 µg/ml to 10000 µg/ml of CPC, and combination groups of Ag 10 µg/ml + CPC 10 µg/ml (G13), Ag 10 µg/ml + CPC 1 µg/ml (G14), and Ag 1 µg/ml + CPC 10 µg/ml (G15). Data were analyzed using One-Way ANOVA and Games-Howell and Tukey HSD pair comparison tests at a significance level of 0.05.
Results: Based on the MTT test and the cell viability exposed to herpes simplex virus type 1, the highest number of living cells belonged to the 10 µg/ml Ag group, followed by 10 µg/ml CPC, 10 µg/ml Ag + 10 µg/ml CPC, 1 µg/ml Ag + 10 µg/ml CPC, and 10 µg/ml Ag + 1 µg/ml CPC groups. In terms of antiviral effect, there was a significant difference between group 1 and groups 3, 4, 5, 6, and 10 (P<0.001), between groups 2 and 3 (P=0.40), between groups 2 and 4 (P=0.041), between group 2 and groups 5 and 6 (P=0.035), between group 7 and groups 10, 11, and 12 (P<0.001), between group 8 and groups 10, 11, and 12 (P<0.001), and between group 9 and groups 10, 11, and 12 (P<0.001). Among combination groups, the most antiviral effect and the least cell toxicity was found in the 10 µg/ml Ag + 10 µg/ml CPC group, while the least antiviral effect was observed in the Ag 10 µg/ml + CPC 1 µg/ml group.
Conclusion: The highest cell viability rate belonged to the 10 µg/ml Ag group, followed by the 10 µg/ml CPC group, and their combination resulted in a reduction of its effect in this area. The antiviral effect of these materials individually was greater than in their combined state. Additionally , the most antiviral effect and the least cell toxicity was found in the 10 µg/ml Ag + 10 µg/ml CPC group among the combination groups.

New perspective of dentistry: Artificial intelligence and its role in the diagnosis of dental diseases; A review article

Mona Fazel Ghaziani

Background and Aims: In recent years, the use of artificial intelligence (AI) has become increasingly common in dentistry because it facilitates the process of diagnosis and clinical decision-making. It is necessary for dentists to be aware of the advantages and disadvantages of artificial intelligence before implementing it. The present study aimed to comprehensively review the various applications of artificial intelligence in the diagnosis of dental diseases along with its challenges and disadvantages.
Materials and Methods: For this review article, a complete search was conducted on the PubMed and Google Scholar databases and studies published in recent years as well as studies published in 2024 were collected using the keywords "artificial intelligence," "dentistry," "diagnosis." Finally, the relevant articles were selected and evaluated, focusing on artificial intelligence in dentistry and the diagnosis of dental diseases.
Results: Advances in artificial intelligence in dental imaging, particularly through machine learning (ML) and artificial neural networks (ANN), have dramatically transformed the way dental disease is diagnosed. These technologies help dentists to analyze complex information and produce more accurate results by using algorithms that allow systems to learn and respond to data. The most recent development in this area is deep learning (DL), which uses multiple layers of neural networks to process unlabeled data and predict outcomes. These techniques are used in various fields such as diagnostic imaging, periodontology, dental caries detection, and osteoporosis screening, which help to improve the quality of dental services. Despite the benefits of AI in clinical dentistry, three controversial challenges remain and need to be addressed: ease of use, return on investment, and evidence of performance, or reliability.
Conclusion: Based on the results, the most important advantage of AI is the diagnosis of dental diseases. AI has great potential to reduce the pressure on health systems by automating routine tasks and improving patient care. However, this technology can never replace human expertise and must be guided by ethical principles. Ultimately, AI is recognized as a valuable tool in dentistry and the final decision-making always remains with the dentist.

The impact of orthodontic treatment-related pain on patients’ orthodontic quality of life in Babol

Meisam Moradi

Background and Aims: Despite the functional and aesthetic benefits, orthodontic treatment is often associated with pain and discomfort that can adversely affect patients’ quality of life. Given the growing emphasis on the patient-reported outcomes in clinical care, this study aimed to investigate the association between the pain intensity caused by orthodontic treatment and orthodontic-related quality of life in patients undergoing fixed orthodontic therapy.
Materials and Methods: This descriptive-analytical cross-sectional study was conducted in 2022 on patients receiving fixed orthodontic treatment with a metallic MBT system (slot 0.022 inch) at a private clinic in Babol, Iran. A total of 85 patients aged 15–25 years were selected using convenience sampling. Pain intensity was assessed using a visual analog scale (VAS) ranging from 0 to 10. Quality of life was evaluated using the persian version of the Orthodontic Quality of Life questionnaire, with a scoring range of 22 to 88. Data were analyzed using independent samples t-test and Pearson’s correlation coefficient in SPSS, with a significance level set at P<0.05.
Results: Among the participants, 72.9% were female, 68.2% were under the age of 20, and 31.8% were aged between 20 and 25 years. The mean pain score was 4.75 ± 1.91, and the mean Oral Health Related Quality of Life (OHRQoL) score was 37.95 ± 9.51. A significant negative correlation was found between the pain intensity and overall OHRQoL, as well as all of its subdomains (oral function, social impact, dentofacial aesthetics, and self-awareness of appearance) (P≤0.001). No statistically significant differences in pain or OHRQoL scores were observed based on gender or age group (P>0.05).
Conclusion: Orthodontic pain has a significant negative impact on patients’ quality of life. Early pain management strategies and supportive interventions during the initial phases of orthodontic treatment can enhance patients’ overall treatment experience and improve compliance.

Assessment of awareness and attitudes of general dentists in Yazd toward digital dentistry: Emphasis on educational needs

Fatemeh Karamad

Background and Aims: Given the rapid growth of digital technologies in dentistry, assessing dentists’ awareness and attitudes toward this transformation is essential. This study aimed to evaluate the awareness and attitudes of general dentists in Yazd-Iran toward digital dentistry in 2025.
Materials and Methods: In this descriptive-analytical study, 135 general dentists in Yazd-Iran were selected through convenience sampling. Data were collected via an online questionnaire including demographic information and the questions related to awareness and attitude. Dat were analyzed using SPSS version 27 and the statistical analysis tests were Mann-Whitney, Kruskal-Wallis, and Chi-square to examine the variables.
Results: A total of 59 men and 76 women with a mean age of 31.92 ± 7.87 years participated in the study. The mean knowledge score was 7.76 ± 2.77 out of 12. Higher knowledge and a more positive attitude were significantly associated with older age, longer work experience, and male gender (P<0.05). Overall, 74.1% of participants were unaware of the well-known CAD/CAM system, 74.8% were unfamiliar with digital implant software, and 60% did not have adequate knowledge of correct application of intraoral scanners. While, 81.5% reported an overall positive attitude, only 11.9% considered their knowledge to be aligned with modern digital technologies.
Conclusion: General dentists demonstrated a moderate level of awareness and the existing knowledge gaps warrant greater attention in both undergraduate and continuing education. Enhancing knowledge among specific groups-such as younger, less experienced, and female dentists—is essential. Significant differences in attitudes were observed according to the age, gender, and years of professional experience.