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Showing 5 results for Mineral Trioxide Aggregate

S. Rahimi , B. Jodeiri ,
Volume 18, Issue 3 (5-2005)

Background and Aim: The goal of endodontics is to seal the root canal system from the orifice to apical constriction completely and tridimensionally.Hence perforations during root canal therapy, because of caries or resorptions must be sealed and obturated with ideal materials. The aim of this study was to histologically compare two kinds of mineral trioxide aggregate Root MTA and Pro Root MTA for furcal perforation repair in developed teeth in dog.

Materials and Methods: In this experimental study, thirty teeth consisting of second, third and fourth mandibular premolars of five German shepherd dogs were selected. Twenty-four teeth were randomly divided into four experimental groups (6 teeth each). One pair of Root MTA and Pro Root MTA groups studied in one month and the other in three months intervals. Positive and negative control groups was each contained three teeth. In positive control group, perforations were not treated and negative control group contained intact teeth. In experimental groups perforations repaired after one week exposure to oral cavity with Root MTA or Pro Root MTA. After time intervals animals were subjected to vital perfusion and 6 m histologic sections were prepared. Inflammation and hard tissue formation were ranked by Cox criteria. Data were analysed using Mann-Whitney and Chi-Square statistical tests with P<0.05 as the limit of significance.

Results: There was statistically significant lower inflammation and higher hard tissue formation in three months Root MTA and Pro Root MTA groups compared to one month interval (P<0.05). There was no statistically significant difference in inflammation and hard tissue formation between Root MTA and Pro Root MTA in each intervals (P>0.05).

Conclusion: Mineral Trioxide Aggregate is an adequate material for furcal perforation repair in dog’s teeth. Root MTA could be a good substitute for Pro Root MTA considering the lower cost and similar characteristics.

Mr. Sharifian , M. Zarrabian , H. Razmi , M. Ghobadi , Mj. Kharrazifard , F. Hemmatzadeh , R Afzalifar ,
Volume 20, Issue 2 (5-2007)

Background and Aim: Mineral Trioxide Aggregate (MTA) is a material used in many endodontic problems. Recently a number of studies, have reported that Portland Cement (PC) and MTA have similar physical, chemical and biologic properties. In addition, a material known as Root MTA which is produced in Iran has been claimed to have similar properties to Pro Root MTA. If these claims are true, possible use of PC and Root MTA in clinic instead of Pro Root MTA will be quite cost effective. The aim of this study was to investigate the toxicity of Pro Root MTA, Root MTA and Portland Cement on L929 mouse fibroblasts.

Materials and Methods: In this experimental study 0, 4, 24 hours and 7 days' extracts of materials were transferred to cell culture plates containing L929 fibroblasts. After 24 hours incubation, cells were stained by Neutral Red (NR), and optical density (OD) of each cell was read with ELISA reader. Data were analyzed using Tukey HSD and one way analysis of variance. P<0.05 was considered as the level of significance.

Results: In all surveyed groups and negative control group, at all time points separated cells from the base of the well were round. Refraction which is a characteristic of cellular death was not observed, whereas the separated cells from the base of well in positive control group showed refractional characteristic.

Conclusion: Based on the findings of this study Pro Root MTA, PC and Root MTA have the same biocompatibility. PC seems to have the potential to be used in the same clinical situation as MTA. However in order to replace MTA with these less expensive materials more in vitro and in vivo studies are suggested.

M. Bidar , J. Tavakol Afshari , F. Shahrami ,
Volume 20, Issue 4 (1-2008)

Background and Aim: Osteoblasts and periodontal ligament cells play a major role in wound healing after root end resection. The interaction of osteoblasts with filling materials is critical in healing of surgical lesions. The aim of this study was to evaluate the morphology and adhesion of human osteoblasts (MG-63 cell line) in contact with IRM, gray MTA, white MTA and Portland cement (PC) as root end filling materials.

Materials and Methods: In this in vitro study, human osteoblasts of osteosarcoma were provided from the cell bank of Iran Pasteur Institute, and cultured in RPMI 1640 medium. Test materials were mixed according to the manufacturer's instructions and placed in contact with osteoblast cells. After the first, third and seventh days discs of materials with grown cells were fixed and examined by scanning electron microscopy.

Results: Results showed that after 7 days most of the osteoblasts were attached to the surface of both gray and white MTA and PC and appeared flat or round, however cells adjacent to IRM were round without any adhesion and spread.

Conclusion: Based on the results of this study, human osteoblasts have a favorable response to gray and white MTA and Portland cement compared to IRM.

Mohamad Saieed Sheykhrezaie, Pegah Saraf, Mohamad Hosein Nekofar, Alireza Mohamadi,
Volume 25, Issue 4 (1-2013)

Background and Aims: The purpose of this study was to evaluate the sealing ability of different thicknesses of orthograde MTA plugs in comparison with 5 mm gutta-percha.

Materials and Methods: Fifty extracted single rooted human teeth were collected. After root canal preparation, the samples were randomly divided into 4 experimental (n=10) and two control groups (n=5). In group 1, the apical 5 mm of the canals were obturated using laterally condensed gutta-percha and sealer AH26. Groups 2, 3 and 4 received 2, 3 and 4-mm thick orthograde MTA plug, respectively. Thereafter, the coronal portion of specimens was exposed to the microbial solution containing streptococcus sanguis and the root tips were placed in phenol red lactose broth. The color changes were observed within 60 days. The data were analyzed with Fisher exact test.

Results: The leakage was found in all samples (100%) in group 1 and 72.7%, 30.8% and 50% of the samples in groups 2, 3 and 4, respectively. Significant difference was found between 3 mm thickness of MTA plug and gutta percha and sealer (P=0.02).

Conclusion: According to the findings, it seems that 3 mm thickness of orthograde MTA plug had better sealing ability than the other thicknesses of MTA plug as well as the 5 mm of gutta-percha.

Noushin Shokouhinejad, Hassan Razmi, Mehrfam Khoshkhounejad, Pegah Firouzmanesh,
Volume 30, Issue 3 (10-2017)

Background and Aims: The aim of this study was to assess the microhardness of BioMTA (OrthoMTA, RetroMTA) in distances of 0.5, 2 and 3.5 mm from the exposed surface to blood, phosphate buffer saline (PBS) or distilled water and to compare to that of ProRoot MTA.
Materials and Methods: One hundred and thirty five semicylindrical polymethyl methacrylate were filled with either ProRoot MTA, OrthoMTA, or RetroMTA. Fifteen molds in each group were exposed to blood, 15 molds to PBS and the other 15 to distilled water. The microhardness of the materials at 0.5, 2 and 3.5 mm distance from the exposed surface to phosphate-buffered saline (PBS) as a synthetic tissue fluid, blood, and distilled water was assessed. The data were analyzed using one-way ANOVA and Tukey post hoc tests.
Results: Exposure to blood significantly decreased the microhardness of all materials at all three points of 0.5, 2 and 3.5 mm (P<0.001). At level of 0.5 and 2 mm distant from blood, OrthoMTA showed significantly the least microhardness value; however, at the point of 3.5 mm, the microhardness of RetroMTA was higher than the two other materials (P<0.001). After exposure of samples to distilled water or PBS, no significant difference was found between the materials at any levels of 0.5, 2, and 3.5 mm (P<0.01).
Conclusion: Blood exposure resulted in the decrease of microhardness of internal part of the materials.

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