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Showing 2 results for Oral Lichen Planus (olp)

Sh. Jafari , M. Khatibi ,
Volume 13, Issue 1 (4-2000)

: Oral lichen planus (OLP) is a chronic and common disease of the oral mucosa, which its etiology, phathogenesis and exact treatment is not definitely known. T-cell mediated immunity is the most probable factor in pathogenesis of OLP. Since TNF-a primarily, as a cytokine, interfers T-Cel mediated immunopathologic reactions, it may also interfere with pathogenesis of OLP.In an observational case- control study, the values of TNF-a in serum of OLP patients were measured and compared with the values of healthy cases. 30 OLP patients and 30 healthy controls have examined with ELISA technique. Data was obtained by observation questionnaire and examination.The mean value of TNF-a in case and control groups were 26.2 and 7.9 pg/ml, respectively, which showed significant difference (PO.005).Considering the TNF-a values with respect to sex and age did not show any significant difference,however the lower TNF-a value was obtained with increasing the age, and higher value observed in females. Higher values of TNF-a found in OLP patients compared with control group. It means TNF-a is an effective factor in OLP. Due to these findings new treatment protocols have been suggested.

Yalda Elham, Neda Moslemi, Hoda Barati,
Volume 31, Issue 4 (1-2019)

Background and Aims: Lichen planus is a chronic inflammatory mucocutaneous disease with unknown etiology. One of the most common manifestations of patients with oral lichen planus is gingival involvement in the form of generalized erythematous areas. The aim of this study was to review the articles evaluating the role of plaque control on the gingival manifestations of oral lichen planus.
Materials and Methods: Motor searches of Ovid Medline and EM base databases, PubMed, Google Scholar, and Science Direct were searched for article published between January 1990 and December 2017 using of relevant key words. After reviewing the abstracts of articles, 20 full articles were selected and among them, 7 relevant articles were reviewed in this study.
Conclusion: From the literature, it was concluded that effective plaque control is the main part of lesions treatment and improvement of symptoms and gingival manifestations of oral Lichen planus.

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