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Comparison Of Therapeutic Effectiveness With Clotrimazole 1% Cream With Terbinafine 1% Cream In Patients Therapy Given To Tinea Corporis And Tinea Cruris In Kashan
Rezvan Talaee , Mohammad Dakhili, Mohammad Ali Asadi, Seyed Hamed Sharif Arani, Hossein Akbari, Afshin Salehi ,
Volume 9, Issue 4 (11-2015)
Abstract

Background and Aim: Dermatophytosis is a skin infection without involving of hair, and in fact, Tinea cruris is a form of body Dermatophytosis. For treatment of these two diseases, topical azole or Alylamines are usually used. The aim of this study was to determine the therapeutic effectiveness of Terbinafine 1% and clotrimazole 1%, respectively.

Materials and Methods: 100 patients suspected to Tinea body, and 50 patients direct suspected to Tinea cruris referred to Reference Laboratory of Kashan were selected randomly at one year, prepared smear with 10% KOH, and SCC culture media. 1% cream of Clotrimazole or Terbinafine prescribed 2 and 4 weeks. Then patients recovery was studied for clinical and laboratory results. The data was collected and analyzed by SPSS and Duncan procedure.

Results: After 2 weeks, clotrimazole was more effective than Terbinafine in the treatment of patients infected by Tinea of the body, but equally effective in patients therapy with Tinea cruris By Terbinafine. As a whole, Clotrimazole was more effective than Terbinafine. However, this differences was not significant (P>0/432).

Conclusion: Clotrimazole is our drug choice for therapy of Dermatophytosis and Tinea cruris, in spite of new drugs, for example Terbinafine.


Investigation of the Antifungal Effects of Carvacrol on Clinical Isolates of Trichophyton Rubrum
Davood Bahrami, Mahin Tavakoli, Bahram Ahmadi,
Volume 19, Issue 6 (3-2026)
Abstract
Background and Aim: Trichophyton rubrum is among the most frequently detected species that cause dermatophyte infections, especially chronic infections, so it requires early diagnosis and appropriate antifungal treatment. Due to the increasing resistance of different species of dermatophytes to antifungals, the use of herbal compounds with antifungal properties can be used as adjuvant therapy or even an alternative therapy. Carvacrol has a wide range of biological activities, including antifungal, antiviral, antibacterial, insecticidal, and antioxidant properties. Accordingly, we aimed to determine the antifungal effect of carvacrol on 12 strains of Trichophyton rubrum in comparison to the antifungal drug terbinafine in vitro. 
Materials and Methods: This investigation was conducted on Trichophyton rubrum isolates that had been previously identified morphologically and molecularly. The protocol used to perform in vitro susceptibility testing was the A38-M-CLSI standard using the Broth Microdilution method. The obtained results were analyzed using SPSS software, and the MIC50, MIC90, and GM of this compound against Trichophyton rubrum isolates were estimated compared to terbinafine.
Results: The minimum inhibitory concentration (MIC) was determined using different concentrations of carvacrol (in the concentration range of 0.25 to 2 μg/mL) and terbinafine (in the concentration range of 0.0625 to 0. 5 μg/mL). The MIC50 and MIC90 values for Carvacrol were determined to be 0. 5 and 2 μg/mL, respectively. Whereas, the corresponding values for terbinafine were calculated at 0.0625 and 0. 5 μg/mL. The GM values were 0.5 for cavacrol and 0.1 for terbinafine. Similar to terbinafine, the antifungal efficacy of the studied compound displayed significant differences against Trichophyton rubrum isolates (P-value<0.05).  
Conclusion: Although the MIC values for carvacrol were higher than those for terbinafine in vitro, it demonstrated significant antifungal activity against Trichophyton rubrum isolates. Therefore, this natural compound seems to be a good option for adjuvant therapy along with antifungals in dermatophyte infections, although the realization of this matter requires further investigation on the combined effect of carvacrol and terbinafine, determining the toxicity of carvacrol, and also examining this compound in vivo.

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