Sarasgani M R, Firoozrai M, Hashemi S J,
Volume 66, Issue 3 (2 2008)
Abstract
Background: Amino acids have different effects on the growth of some dermatophytes. Some may encourage growth, while others inhibit it. The concentrations of some amino acids also are an important factor for their effect. To investigate the effects of amino acids on the growth of dermatophytes, the dermatophytes Trichophyton schoenleinii and Microsporum canis, obtained from Iran.
Methods: In this study, two concentrations (1g/dL and 0.1g/dL) of 23 amino acids were added to the Sabouraud glucose agar media of these dermatophytes. The experiment was carried out three times. After two weeks, the means of the colonies were compared with the control, which had no amino acids added to the Sabouraud glucose media.
Results: The results showed that L-cysteine hydrochloride, L-cysteine, L-aspartic acid, L-glutamic acid and DL-tryptophan and L-tyrosine had the most inhibitory effects on the studied dermatophytes, while arginine L-lysine and L-methionine had moderate effects and the rest of amino acids had less inhibitory, or even stimulatory, effects on the growth of the dermatophytes. M. canis and T. schoenleinii has a different sensitivity to amino acids. This data indicates that sulfur-containing amino acids and acetic amino acids have greater inhibitory effect against these two dermatophytes.
This may be an indicator that such amino acids used in, for example, sweetener may have an important role in immunity to these dermatophytes. Thus, some amino acids may be used as a possible treatment for dermatophytosis.
Conclusion: Among the amino acids L-cysteine hydrocholoride, glutamic acid, aspartic acid, and tryptophan are the most inhibitory effect s against of T. schoenleinii and M. canis.
