Showing 5 results for Mansoori
M Farahvash , P Mansoori , S Arad ,
Volume 55, Issue 6 (1 1997)
Abstract
Port wine stains are benign but cosmetically devasting congenital angiomas. The argon laser is a therapeutic device newly applied to this condition. Our program was begun 6 years ago. From the beginning, the study was conceived as a clinical investigation of both the port wine stain and its argon laser therapy. A total of 218 patients with port wine stains have been studied and many aspects of their clinical condition detailed. Employing the Argon laser, test spots have been carried out in patients and the results have been analyzed with clinical aspects of the lesions. Altogether, 501 treatments were performed in 218 patients. Good to excellent results were obtained in 81 patients. Moderate Result was obtained in 31 weak result in 65 patients. Most common complication were hyperpigmentation and depressed scar.
P Mansoori , M Mortazavi ,
Volume 56, Issue 2 (30 1998)
Abstract
Griseofulvin is a well-known, effective, systemic antifungal agent which has not been used topically in the current clinical practice. In order to treat the common superficial fungal infection of tinea versicolor, a new topical formulation of griseofulvin (1%) was tried in 105 patients during a double blind study and its efficacy compared with placebo (its vehicle) and clotrimazol (1%) solutions. As a result, 17.9% of patients treated by griseofulvin, 38.9% of patients on clotrimazole and 3.3% of patients receiving placebo were completely cured. This study suggests that in proper solvent, topical griseofulvin might show its antifungal action.
Saehi Nodeh A, Moazzeni S M, Mansoori P,
Volume 62, Issue 2 (12 2004)
Abstract
Background: Alopecia areata is a common, inflamatory and chronic disease of hair and nails, which in some cases result in growth inhibition and lose of hairs. Several factors such as genetic factors, autoimmunity, atopy, stress, fear etc, are known as effective factors in induction and severity of the disease, but the ethiology of this disease is not known exactly so far. Some evidences such as presence of an autoantibodies against hair follicules and infiltration of immunocompetent cells in affected areas of the disease lead that most investigators classify alopecia as autoimmune disease. In one investigation in immunology department of Tarbiat Modarres university concerning the humoral immunity in alopecia pathogenesis some evidences were found for the presences of a neoantigen in affected hair follicles. Since various studies indicates that cellular arm of the immune system is more important in alopecia areata pathogenesis, in this investigation we studied the existence of neoantigens in affected hair follicles using lymphocyte transformation test (LTT).
Materials and Methods: The proliferation responses of peripheral blood mononuclear cells (MNC) from alopecia patients and normal individuals were investigated against the follicular extracts of affected and normal hairs separately.
Results: Our results indicate a non significant difference between proliferation responses of MNC’s from alopecia patients and normal controls against follicular extract of normal hairs. These responses were not significantly different against folliclar extracts of affected hairs as well. Regarding our results.
Conclusion: We could not show the existence of a neoantigen in alopecia hair follicles, but the obtained results can not completely reject the role of a neoantigen in alopecia pathogenesis as well, because in LTT the responding cells are of memory type and these cells may be very low in peripheral blood. The immune response in this disease may be restricted to affected areas such as hair follicles, so non-different proliferation response of peripheral blood lymphocytes can not exactly reflect the quality of immune response in affected areas. More investigations are needed to clear this matter.
M. Keshavarz, P. Hasanain, M. Parviz, M. Mansoori, N. Soltani, N. Mirazi,
Volume 64, Issue 6 (3 2006)
Abstract
Background: Diabetes mellitus is a chronic disease that is associated with numerous complications like peripheral neuropathies. It has been shown that hyperglycemia may contribute to its development but the exact pathophysiology underlying this complication has not been fully understood. Since it has been suggested that oral magnesium supplementation can prevent hyperglycemia induced by diabetes, this study was designed to examine the protective effect of oral magnesium administration on thermal hyperalgesia in streptozocin (STZ) induced diabetic rats.
Methods: Male adult wistar rats were divided equally into control, magnesium-treated control, diabetic and magnesium-treated diabetic groups. In magnesium-treated diabetic rats, magnesium sulfate (10 gr/L) was added into drinking water since diabetes was established (10 days after STZ injection) and continued for 8 weeks. Mg-treated control animals received magnesium sulfate in the same dose and time period. The other two groups control and diabetic animals, only received tap water.
Results: A significant decrease in thermal pain threshold and plasma magnesium levels and also a dramatic increase in plasma glucose levels were seen in diabetic rats eight weeks after diabetes induction. Eight weeks magnesium therapy after the diagnosis of diabetes, could prevent reduction in thermal pain threshold and also restore plasma magnesium and glucose levels in magnesium-treated diabetic animals.
Conclusion: Oral magnesium can prevent hypomagnesaemia, hyperglycemia and thermal hyperalgesia in diabetic rats.
Mansoori M, Parviz M, Keshavarz M, Soltani N, Gharibzadeh Sh,
Volume 65, Issue 13 (Vol 65, Supplement 1 2008)
Abstract
Background: Diabetes mellitus is a common metabolic disorder accompanied with
structural and functional changes in central and peripheral nervous system. Researches
showed, memory disturbance were occurred in the course of diabetes. On the other hand,
magnesium deficit has been described in diabetic patients. Some researches were showed
that, appropriate magnesium supplementation can play a positive role in diabetic control.
Methods: Locally produced male rats were used. Diabetes was induced with intravenous
injection of 40 mg/kg streptozotosin. In treatment groups, the animals were received
magnesium sulfate via drinking water (10 g/l). Eight weeks after diabetes confirmation,
the animals were assessed on Morris Water Maze.
Results: A significant decrease in time of platform finding (latency) and distance of
swimming in all four experimental days were seen in all groups. Mean latency in diabetic
group was significantly higher than the other. This weak response was almost completely
prevented by magnesium sulfate administration.
Conclusion: It seems that after eight weeks magnesium sulfate administration (10g/l),
spatial memory of the animals was improved in comparison to diabetic group that can
suggest role of magnesium in recovery of diabetic animal memory.
