Tehran University Medical Journal
مجله دانشکده پزشکی، دانشگاه علوم پزشکی تهران
Tehran Univ Med J
Medical Sciences
http://tumj.tums.ac.ir
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10.18869/acadpub.tumj
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مقایسه ژنهای کدکننده سایتوکینهای سلولهای TH1 و TH2 بهروش PCR در بافت پولیپ بینی افراد آلرژیک و غیرآلرژیک
The comparison of TH1 and TH2 cytokines gene expression in allergic and non-allergic patients with nasal polyps by PCR
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<p dir="rtl" style="text-align: justify direction: rtl unicode-bidi: embed" class="MsoNormal"><strong><span style="font-size: 10pt">زمینه و هدف:</span><em><span style="font-size: 10pt"> </span></em></strong><span style="font-size: 10pt">مطالعات زیادی در مورد
نقش سیستم ایمنی بهعنوان زمینهساز ایجاد پولیپ بینی در دست اجرا است. بهمنظور
بررسی عملکرد احتمالی سلولهای </span><span style="font-size: 7pt">T</span><span style="font-size: 8pt">h</span><span style="font-size: 7pt">1</span><span style="font-size: 10pt"> <span lang="AR-SA">(</span></span><span style="font-size: 7pt">T-H</span><span style="font-size: 8pt">elper </span><span style="font-size: 7pt">1</span><span style="font-size: 10pt">) و </span><span style="font-size: 7pt">T</span><span style="font-size: 8pt">h</span><span style="font-size: 7pt">2</span><span style="font-size: 10pt"> <span lang="AR-SA">(</span></span><span style="font-size: 7pt">T-H</span><span style="font-size: 8pt">elper </span><span style="font-size: 7pt">2</span><span style="font-size: 10pt">) در تشدید
بیماری و یا القا با زمینه آلرژی و بیماران پولیپوز در این مطالعه ژنهای سایتوکینی
دخیل در دو گروه مبتلا به پولیپ بینی آلرژیک و غیر آلرژیک بررسی شد.</span><span style="font-size: 9pt"> <br></span></p><p dir="rtl" style="text-align: justify direction: rtl unicode-bidi: embed" class="MsoNormal"><span style="font-size: 9pt"></span><strong><span style="font-size: 10pt">روش بررسی:</span><em><span style="font-size: 10pt"> </span></em></strong><span style="font-size: 10pt">75 بیمار مبتلا به پولیپ بینی با
میانگین سنی بیماران 38 سال (از 18 تا 81 سال) مورد مطالعه قرار گرفتهاند. از این
بیماران تست غلظت تام </span><span style="font-size: 7pt">I</span><span style="font-size: 8pt">g</span><span style="font-size: 7pt">E</span><span style="font-size: 10pt"> (</span><span style="font-size: 8pt">Immunoglobin </span><span style="font-size: 7pt">E</span><span style="font-size: 10pt">) سرم و </span><span style="font-size: 7pt">I</span><span style="font-size: 8pt">g</span><span style="font-size: 7pt">E</span><span style="font-size: 10pt"> اختصاصی سرم و تست جلدی جهت تایید دو گروه آلرژیک (38 نفر) و غیر
آلرژیک (37 نفر) انجام شد. بهمنظور ارزیابی همبستگی احتمالی واکنشهای آلرژیک در
مجاری تنفسی فوفانی و پولیپ بینی بروز این ژنها با روش </span><span style="font-size: 8pt">Reverse
Transcriptase-Polymerase Chain Reaction </span><span style="font-size: 7pt">(RT-PCR)</span><span style="font-size: 10pt"> بررسی گردید.</span><strong><span style="font-size: 10pt"> <br></span></strong></p><p dir="rtl" style="text-align: justify direction: rtl unicode-bidi: embed" class="MsoNormal"><strong><span style="font-size: 10pt"></span></strong><strong><span style="font-size: 10pt">یافتهها:</span></strong><span style="font-size: 10pt"> </span><span style="font-size: 10pt">فراوانی بروز ژنهای سایتوکینهای اینترفرون گاما (5/39%
در مقابل 2/16%، 30/0</span><span style="font-size: 7pt">P=</span><span style="font-size: 10pt">) و اینترلوکین 4 (7/44% در مقابل 9/18%، 02/0</span><span style="font-size: 7pt">P=</span><span style="font-size: 10pt">) در بیماران
آلرژیک بیشتر از غیر آلرژیک مشاهده گردید. بروز ژن سایتوکینهای اینترلوکین-10،
اینترلوکین-12 فراکسیونهای </span><span style="font-size: 7pt">P40</span><span style="font-size: 10pt"> و </span><span style="font-size: 7pt">P35</span><span style="font-size: 10pt"> بین دو گروه اختلاف معنیدار آماری نداشت.</span><strong><em><span style="font-size: 10pt"> <br></span></em></strong></p><p dir="rtl" style="text-align: justify direction: rtl unicode-bidi: embed" class="MsoNormal"><strong><span style="font-size: 10pt">نتیجهگیری:</span><em><span style="font-size: 10pt"> </span></em></strong><span style="font-size: 10pt">این تحقیق نشان میدهد که عدم
تعادل بین سلولهای </span><span style="font-size: 7pt">T</span><span style="font-size: 8pt">h</span><span style="font-size: 7pt">1</span><span style="font-size: 10pt"> <span lang="AR-SA">و </span></span><span style="font-size: 7pt">T</span><span style="font-size: 8pt">h</span><span style="font-size: 7pt">2</span><span style="font-size: 10pt"> نقش مهمی در پاتوفیزیولوژی پولیپ بینی دارد.
بنابراین اگرچه پولیپ بینی یک بیماری با اتیولوژیهای مختلف است ولی التهاب مزمن
مداوم عامل اصلی در ایجاد آن محسوب میشود.</span></p>
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<!--stripped--> <strong>Background:</strong><strong> </strong>Too many studies are in the process
of determining the probable role of immune system in the etiopathogenesis of
nasal polyposis. This study was designed to identify the probable participation
of Th1, Th2 lymphocytes in the induction and progression
of nasal polyposis.<br><strong>Methods:</strong> <strong> </strong>Seventy-five patients, 42 male and 33 female, with
nasal polyposis were examined for total serum IgE, specific serum IgE and reaction to skin test for differentiating allergic from
non-allergic participants in Rasoul Akram Hospital during 2010. To determine the possible correlation of allergic
reactions in the upper respiratory tract and nasal polyposis, cytokine gene
expression was evaluated on the extracted RNA by
RT-PCR. The data were analyzed by using c<sup>2</sup>, independent t-test, correlation and
Receiver operating characteristic (ROC)
curve.<br><strong>Results:</strong> <strong> </strong>The mean
age of participants was 38 years (18-81 years). IFN-γ
and IL-4 gene expressions were more prevalent
in allergic than non-allergic individuals (IFN-γ:
39.5% vs. 14.2%, P=0.3 and IL-4: 44.7% vs. 18.9%, P=0.02, respectively). IL-10 and IL-12 (P35 and P40 fractions) genes were not
significantly different between the two groups. IL-10 and IL-12 (P35, P40) genes did not differ significantly either.<br><strong>Conclusion: </strong> This research suggests that overproduction of
cytokines and an imbalance of Th1
and Th2 cell production may
play an important role in the pathophysiology of allergic or non-allergic nasal
polyp formation. Thus, although nasal polyposis is a multifactorial disease
with several different etiological factors, chronic persistent inflammation is
undoubtedly a major factor irrespective of the etiology.</p>
پولیپ بینی،سلولهای Th1 و Th2،سایتوکین،RT،PCR
Cytokines,nasal polyposis,RT-PCR,Th1,Th2 cells
576
580
http://tumj.tums.ac.ir/browse.php?a_code=A-10-25-197&slc_lang=fa&sid=1
Farhadi
M
محمد
فرهادی