Background & Aim: Number of patients with bloodborn disease is increased. Because of degenerative effects of the disease on body&aposs organs, and patient&aposs need to hospitalization, contamination risk for nurses and other patients is also increased. So investigation of the performance the principals of the safety injection by nurses are necessary.

Methods & Materials: This study is a descriptive research. Sample of the study were 85 nurses employed in emergency units of the selected hospitals. The research data gathering tools were a questionnaire included 7 question about demographic data and 3 checklists included 29, 20, 15 objects about performance of the safety injection in three steps (pre, during, and after injection). The statistical tests included t-test, Pearson correlation. Data analysis performed by SPSS software.

Results: This study showed that the majority of subjects were 23-30 years old (60%), female (70.6%), have BS (97.6%) in nursing and clinical experience under 5 years in hospital (55.3%) and emergency unit (80%) and didn’t participant in infection control course (75.3%) and work in rotation shift (82.4%). About half of the nurses (49.4%, 51.8%, 55.3%), had desirable performance in three steps of injection. Performance of safety injection had a significant correlation with sex (p=0.002), and preinjection step with during injection step and after injection (p=0.000), (p=0.001) respectively.

Conclusion: According to the results of this study, the half of nurses had desirable performance in injection process, but the half of them had undesirable performance. It is suggested that nurses and managers pay more attention and try to performance standard and world precautions and principals of safety injection to prevent convection of bloodborn diseases.