Background & Aim: Male andropause begins with hormonal, physiological and chemical changes, and usually occurs in men between the ages of 40 to 55 years. These changes affect their quality of life. Hence, the current study investigated the quality of life of men with andropause and its related factors.

Methods & Materials: This preliminary cross-sectional study was conducted through the census method on 80 males aged 40 to 60 years, employed at the schools of Tehran University of Medical Sciences. Data were collected in 2014 using a demographic questionnaire, the Short-Form 36 (QOL) questionnaire, and the Persian version of the Aging Males' Symptoms (AMS) questionnaire. Data were analyzed by SPSS software v.22 through descriptive and inferential statistics (Independent t-test, one-way ANOVA, Pearson’s Correlation Coefficient and Stepwise multivariate Regression). The level of significance was set at 0.05.

Results: The mean age of the andropausal men was 47.6±4.79 years and the majority (38.8%) of the samples were in the 45-49 age group. The mean quality of life score was 61.75±13.52. Stepwise regression showed a significant relationship between age and the scores of overall quality of life, physical and psychological health dimensions. Moreover, significant associations were observed between the overall quality of life score and the andropause severity, and between physical health dimension and sleep hours per day.

Conclusion: This study indicates that andropause lowers the quality of life, and age, andropause severity and sleep hours affect the quality of life in the andropausal men.