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Hyperhomocysteinemia is a condition which , in the absence of kidney disease , indicates a disturpted sulfur amino acid metabolism , either because of vitamin deficiency (folate , B12 and B6 ) or a genetic defect. Epidemiologicevidence suggests that mild Hyperhomocysteinemia is associated with increased risk of arteriosclerotic disease and stroke . Hyperhomocysteinemia is an independent risk factor for CHD .Vitamin therapy with the above vitamins can reduce homocysteine level efficiently.