Volume 5, Issue 3 (17 2006)
ijdld 2006, 5(3): 226-235 |
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Hossein-Nezhad A, Maghbooli J, Arzaghi S M, Shafaei A, Rahmani M, Larijani B. RELATIONSHIP BETWEEN VITAMIN D DEFICIENCY AND GESTATIONAL DIABETES MELLITUS. ijdld 2006; 5 (3) :226-235
URL: http://ijdld.tums.ac.ir/article-1-363-en.html
URL: http://ijdld.tums.ac.ir/article-1-363-en.html
Arash Hossein-Nezhad 
, Jila Maghbooli , Seyed Masoud Arzaghi , Alireza Shafaei , Mazaher Rahmani , Bagher Larijani * 1
, Jila Maghbooli , Seyed Masoud Arzaghi , Alireza Shafaei , Mazaher Rahmani , Bagher Larijani * 1
Abstract: (12309 Views)
Background: Although there is increasing evidences that vitamin D is related to the occurrence of diabetes mellitus, its relation to glucose metabolism in pregnancy is not well studied. This study investigated 25-hydroxyvitamin D deficiency status in GDM pregnant women.
Methods: As a cross sectional study we recruited 741 pregnant women referred to five university educating hospital clinics. The universal screening was performed with a GCT-50g and those with plasma glucose level ≥130mg/dl, were diagnosed as GDM, if they had an impaired GTT-100g based on Carpenter and Coustan criteria. The levels of insulin was studied during OGTT-100g. Serum concentrations of 25-hydroxy vitamin D was measured too.
Results: Univeriate analysis revealed that 25 (OH) vit D concentrations were positively correlated with HOMA and ISOGTT index. Subjects with hypovitaminosis D (<12.5nmol/dl) had greater prevalence of GDM than others.
Conclusion: The results reveal a positive association between 25(OH) vit D concentrations and insulin sensitivity. Vit D deficiency is more prevalent in patients with GDM than normal pregnant women, So vit D supplementation may control glucose levels and improves outcome of pregnancy.
Methods: As a cross sectional study we recruited 741 pregnant women referred to five university educating hospital clinics. The universal screening was performed with a GCT-50g and those with plasma glucose level ≥130mg/dl, were diagnosed as GDM, if they had an impaired GTT-100g based on Carpenter and Coustan criteria. The levels of insulin was studied during OGTT-100g. Serum concentrations of 25-hydroxy vitamin D was measured too.
Results: Univeriate analysis revealed that 25 (OH) vit D concentrations were positively correlated with HOMA and ISOGTT index. Subjects with hypovitaminosis D (<12.5nmol/dl) had greater prevalence of GDM than others.
Conclusion: The results reveal a positive association between 25(OH) vit D concentrations and insulin sensitivity. Vit D deficiency is more prevalent in patients with GDM than normal pregnant women, So vit D supplementation may control glucose levels and improves outcome of pregnancy.
Type of Study: Research |
Subject:
General
Received: 2006/03/16 | Accepted: 2006/06/17 | Published: 2013/10/3
Received: 2006/03/16 | Accepted: 2006/06/17 | Published: 2013/10/3
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