Volume 4, Issue 3 (17 2005)
ijdld 2005, 4(3): 49-55 |
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Sheikholeslami H, Boostani K, Hashemipoor S, Hadjmanoochehri F, Ziaii A. COMPARING FREQUENCY OF CELIAC DISEASE IN PATIENTS WITH DIABETES MELLITUS TYPE I AND NON-DIABETIC , HEALTHY PERSONS. ijdld 2005; 4 (3) :49-55
URL: http://ijdld.tums.ac.ir/article-1-404-en.html
URL: http://ijdld.tums.ac.ir/article-1-404-en.html
Homayon Sheikholeslami 
, Kamal Boostani * 1, Sima Hashemipoor , Fatemeh Hadjmanoochehri , Amir Ziaii
, Kamal Boostani * 1, Sima Hashemipoor , Fatemeh Hadjmanoochehri , Amir Ziaii
Abstract: (7654 Views)
Background: Several studies and research have shown a higher prevalence of celiac disease (CD) and elevation of serum antibody (AGA-IgA & IgA-tTG & EMA-IgA ) in patient with diabetes mellitus type I (T1DM) in versus general and non-diabetic population. Thus screening of CD is recommended in T1DM). This study was conducted to compare frequency of celiac disease in patients with T1DM and healthy persons.
Methods: As a case-control study,60 patient with T1DM that reffered to endocrine clinic of Qazvin’s Boo-Ali hospital , in nearly one year period were enrolled as case group. 60 non-diabetic healthy subjects with age and sex matched, were selected as control group. Blood levels of Total IgA, AGA-IgA and IgA-tTG were measured in all of them, subjects who had elevated of both AGA-IgA and IgA-tTG underwent an upper GI endoscopy and biopsy was done from distal part of duodenum.
Results: Any one in case group hadn't IgA deficiency. 14 subjects in control and 12 subjects in case group had positive AGA-IgA that there was no significant difference between them . 2 subject of case group had positive IgA-tTG. Duodenal biopsy in 1 of 14 cases who had elevated AGA-IgA )1 of 2 cases who had elevated IgA-tTG) , revealed total villous atrophy indicating CD (Type IIIC with revised Marsh criteria 2001) and in other cases pathologic findings were normal or with nonspecific changes.
Conclusion: Frequency of CD in T1DM in our study is 1.67%. There is not any significant difference between case and control groups in prevalence of Celiac disease . But we conclused that screening with AGA-IgA is not a reliable screening test for CD , because there is not significant difference between T1DM and general population .
Methods: As a case-control study,60 patient with T1DM that reffered to endocrine clinic of Qazvin’s Boo-Ali hospital , in nearly one year period were enrolled as case group. 60 non-diabetic healthy subjects with age and sex matched, were selected as control group. Blood levels of Total IgA, AGA-IgA and IgA-tTG were measured in all of them, subjects who had elevated of both AGA-IgA and IgA-tTG underwent an upper GI endoscopy and biopsy was done from distal part of duodenum.
Results: Any one in case group hadn't IgA deficiency. 14 subjects in control and 12 subjects in case group had positive AGA-IgA that there was no significant difference between them . 2 subject of case group had positive IgA-tTG. Duodenal biopsy in 1 of 14 cases who had elevated AGA-IgA )1 of 2 cases who had elevated IgA-tTG) , revealed total villous atrophy indicating CD (Type IIIC with revised Marsh criteria 2001) and in other cases pathologic findings were normal or with nonspecific changes.
Conclusion: Frequency of CD in T1DM in our study is 1.67%. There is not any significant difference between case and control groups in prevalence of Celiac disease . But we conclused that screening with AGA-IgA is not a reliable screening test for CD , because there is not significant difference between T1DM and general population .
Keywords: Celiac disease, Diabetes mellitus type I, IgA anti-Glidine, IgA anti-tissue transglutaminase
Type of Study: Research |
Subject:
General
Received: 2004/11/13 | Accepted: 2005/06/10 | Published: 2013/10/1
Received: 2004/11/13 | Accepted: 2005/06/10 | Published: 2013/10/1
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