Volume 2, Issue 2 (17 2003)
ijdld 2003, 2(2): 111-115 |
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Larijani B, Yarahmadi S, Javadi E, Shooshtaryzadeh P, Akhsvan hejazi S M, Gholazmpor Dahaki M. AUTOIMMUNE THYROID DISORDERS IN PATIENTS WITH DIABETES TYPE 1 . ijdld 2003; 2 (2) :111-115
URL: http://ijdld.tums.ac.ir/article-1-465-en.html
URL: http://ijdld.tums.ac.ir/article-1-465-en.html
Bagher Larijani 
, Shahin Yarahmadi , Ebrahim Javadi , Payman Shooshtaryzadeh * 1, Seyed Majid Akhsvan hejazi , Mahyar Gholazmpor Dahaki
, Shahin Yarahmadi , Ebrahim Javadi , Payman Shooshtaryzadeh * 1, Seyed Majid Akhsvan hejazi , Mahyar Gholazmpor Dahaki
Abstract: (10413 Views)
Background: Diabetes type 1 is characterized by autoimmune destruction or primary dysfunction of pancreatic cells. The more common form is the autoimmune type, which can be associated with other endocrine malfunction such as adrenal insufficiency and Hashimoto’s thyroiditis. Autoimmune thyroiditis is characterized by presence of anti TG, anti TPO and anti TSH antibodies in the plasma. This study has investigated the prevalence of autoimmune thyroid disorders in type 1 diabetic patients.
Methods: 200 type 1 diabetics and 200 age/sex matched non-diabetic controls were recruited. Blood samples were taken to determine serum levels of thyroid hormones (T3RU, T3, T4, and TSH) and antithyroid antibodies.
Results: TG-Ab and TPO-Ab levels were significantly higher (P<0.001) in diabetics compared to controls (mean TG-Ab: 955.7±495.5 in diabetics and 451.0±189.5 in controls mean TPO-Ab: 463.2±182.3 in diabetics and 112.4±38.3 in controls). Clinical and subclinical hyperthyroidism was four times more common in diabetics. Conclusion: It seems reasonable that type 1 diabetic patients, especially those at younger ages, be screened for thyroid hormones and anti-thyroid antibodies
Methods: 200 type 1 diabetics and 200 age/sex matched non-diabetic controls were recruited. Blood samples were taken to determine serum levels of thyroid hormones (T3RU, T3, T4, and TSH) and antithyroid antibodies.
Results: TG-Ab and TPO-Ab levels were significantly higher (P<0.001) in diabetics compared to controls (mean TG-Ab: 955.7±495.5 in diabetics and 451.0±189.5 in controls mean TPO-Ab: 463.2±182.3 in diabetics and 112.4±38.3 in controls). Clinical and subclinical hyperthyroidism was four times more common in diabetics. Conclusion: It seems reasonable that type 1 diabetic patients, especially those at younger ages, be screened for thyroid hormones and anti-thyroid antibodies
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