Volume 18, Issue 5 (7-2019)
ijdld 2019, 18(5): 236-245 |
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Shahidi F, Yazdani F, Gaieni A, Karimi P.
COMPARISON OF THE EFFECT OF EIGHT WEEKS OF MODERATE CONTINUOUS AND SEVER INTERVAL TRAINING ON CARDIAC ANGIOGENESIS IN WISTAR MALE DIABETIC RATS
. ijdld 2019; 18 (5) :236-245
URL: http://ijdld.tums.ac.ir/article-1-5850-en.html
URL: http://ijdld.tums.ac.ir/article-1-5850-en.html
1- Department of Physiology, Faculty of Physical Education and Sport Sciences, Shahid Rajaee Tarbiat Modarres University, Tehran, Iran
2- Department of Physiology, Faculty of Physical Education and Sport Sciences, Shahid Rajaee Tarbiat Modarres University, Tehran, Iran ,Yaziferi@gmail.com
3- Department of Physiology, Faculty of Physical Education and Sports Science, University of Tehran, Tehran, Iran
4- Department of Medicine, Faculty of Neuroscience, Tabriz University of Medical Sciences, Tabriz, Iran
2- Department of Physiology, Faculty of Physical Education and Sport Sciences, Shahid Rajaee Tarbiat Modarres University, Tehran, Iran ,
3- Department of Physiology, Faculty of Physical Education and Sports Science, University of Tehran, Tehran, Iran
4- Department of Medicine, Faculty of Neuroscience, Tabriz University of Medical Sciences, Tabriz, Iran
Abstract: (2656 Views)
Background: Diabetic cardiomyopathy is the first cause of death in diabetic patients and angiogenesis is the most important mechanism for the recovery of heart blood flow in physiologic and pathologic conditions. The purpose of this study was to compare the effect of eight weeks of moderate continuous and sever interval training on heart angiogenesis in Wistar male diabetic rats.
Methods: 32 Wistar rats were randomly assigned into 4 groups: healthy non-exercised, diabetic no exercise, diabetic + moderate continuation and diabetic + severe interval exercises. Two types of exercises were calibrated and the exercise intensity was determined based on the maximum oxygen consumption and 5 days a week. The pro-angiogenic (VEGF, MMP2, TGFβ1) and anti-angiogenic (TIMP2) agents of the left ventricle of the heart were taken from the rat after 48 hours of the last training session. Western blot method was used to evaluate the synthesis of proteins involved in angiogenic route. Data were measured by one-way variance analysis with repeated measurements (P =0/000).
Results: The results showed that the levels of proangiogenic VEGF, MMP2, TGFβ1 significantly increased, but the anti-angiogenic factor of TIMP2 decreased (P <0.05). In addition, the maximum level of oxygen consumed in both continuous and periodic training groups showed a significant increase.
Conclusion: Moderate and continuous exercise increases angiogenic factors in the heart of diabetic Wistar rats, which is a good way to reduce the mortality rate of diabetes.
Methods: 32 Wistar rats were randomly assigned into 4 groups: healthy non-exercised, diabetic no exercise, diabetic + moderate continuation and diabetic + severe interval exercises. Two types of exercises were calibrated and the exercise intensity was determined based on the maximum oxygen consumption and 5 days a week. The pro-angiogenic (VEGF, MMP2, TGFβ1) and anti-angiogenic (TIMP2) agents of the left ventricle of the heart were taken from the rat after 48 hours of the last training session. Western blot method was used to evaluate the synthesis of proteins involved in angiogenic route. Data were measured by one-way variance analysis with repeated measurements (P =0/000).
Results: The results showed that the levels of proangiogenic VEGF, MMP2, TGFβ1 significantly increased, but the anti-angiogenic factor of TIMP2 decreased (P <0.05). In addition, the maximum level of oxygen consumed in both continuous and periodic training groups showed a significant increase.
Conclusion: Moderate and continuous exercise increases angiogenic factors in the heart of diabetic Wistar rats, which is a good way to reduce the mortality rate of diabetes.
Keywords: Angiogenesis, Diabetes, Heart Muscle, Continuous Moderate Exercise, Interval Severe Exercises
Type of Study: Research |
Subject:
General
Received: 2019/05/6 | Accepted: 2019/10/7 | Published: 2019/07/1
Received: 2019/05/6 | Accepted: 2019/10/7 | Published: 2019/07/1
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