Volume 19, Issue 3 (2-2020)
ijdld 2020, 19(3): 134-142 |
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Hosseini M, Hosseini M. THE SYNERGISTIC EFFECT OF EIGHT WEEKS HIGH-INTENSITY INTERVAL TRAINING AND RESVERATROL CONSUMPTION ON IL-10 AND TNF- Α IN DIABETIC MALE RATS. ijdld 2020; 19 (3) :134-142
URL: http://ijdld.tums.ac.ir/article-1-5923-en.html
URL: http://ijdld.tums.ac.ir/article-1-5923-en.html
1- Department of exercise physiology. East Tehran Branch, Islamic Azad University, Tehran, Iran , mhbisadi@yahoo.com
2- Department of exercise physiology. East Tehran Branch, Islamic Azad University, Tehran, Iran
2- Department of exercise physiology. East Tehran Branch, Islamic Azad University, Tehran, Iran
Abstract: (1645 Views)
Background: The proinflammatory cytokines of tumor necrosis factor alpha TNF-α and anti-inflammatory interleukin-10 have important roles in inducing and preventing systemic inflammation, respectively. The purpose of this study was to the synergistic effect of High-Intensity Interval training and resveratrol consumption on IL-10 and TNF- α in diabetic rats.
Methods: In this experimental study, 32 diabetic rats 225± 10 g based on Cohen's sample size estimation table diabetic with combination of high-fat diet and streptozotocin (STZ) injection, were randomly divided into four groups: control(C), supplement(M), training (T)and training + supplement(TM). The training groups were exposed to high-intensity interval training with an intensity of 90 to 100% VO2max for 8 weeks, 5 sessions per week, each session for 18 minutes. The supplement groups received 10 mg / kg of resveratrol daily for eight weeks, three times a week by gavage. Blood samples were taken 48 hours after the last training session. Data were analyzed using one-way analysis of variance and SPSS software version 24 (ANOVA).
Results: Results showed that IL-10 increased in the experimental groups but was not significant (P=0.109). TNF-α levels decreased in the TM group, whereas it increased in the T and M groups, which was significant compared to the TM group (P=.000). Fasting glucose, insulin and insulin resistance index decreased significantly in experimental groups (P=.000).
Conclusion: Eight weeks of high-intensity interval training plus resveratrol can have a positive effect on inflammation and insulin resistance by increasing IL-10 and decreasing TNF-α.
Methods: In this experimental study, 32 diabetic rats 225± 10 g based on Cohen's sample size estimation table diabetic with combination of high-fat diet and streptozotocin (STZ) injection, were randomly divided into four groups: control(C), supplement(M), training (T)and training + supplement(TM). The training groups were exposed to high-intensity interval training with an intensity of 90 to 100% VO2max for 8 weeks, 5 sessions per week, each session for 18 minutes. The supplement groups received 10 mg / kg of resveratrol daily for eight weeks, three times a week by gavage. Blood samples were taken 48 hours after the last training session. Data were analyzed using one-way analysis of variance and SPSS software version 24 (ANOVA).
Results: Results showed that IL-10 increased in the experimental groups but was not significant (P=0.109). TNF-α levels decreased in the TM group, whereas it increased in the T and M groups, which was significant compared to the TM group (P=.000). Fasting glucose, insulin and insulin resistance index decreased significantly in experimental groups (P=.000).
Conclusion: Eight weeks of high-intensity interval training plus resveratrol can have a positive effect on inflammation and insulin resistance by increasing IL-10 and decreasing TNF-α.
Type of Study: Research |
Subject:
Special
Received: 2020/01/30 | Accepted: 2020/08/19 | Published: 2020/02/29
Received: 2020/01/30 | Accepted: 2020/08/19 | Published: 2020/02/29
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