Volume 21, Issue 1 (3-2021)
ijdld 2021, 21(1): 39-48 |
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Hosseini S, Esmaelzadeh Toloee M. The Effect of Eight Weeks of High-Intensity Interval Training and Endurance On Blood Glucose and TORC1 Protein Content in Subcutaneous Adipose Tissue of Obese with Type 2 Diabetes Rats. ijdld 2021; 21 (1) :39-48
URL: http://ijdld.tums.ac.ir/article-1-6037-en.html
URL: http://ijdld.tums.ac.ir/article-1-6037-en.html
1- Department of Exercise Physiology, Sport Sciences Faculty, Shomal University, Amol, Iran
2- Department of Exercise Physiology, Sport Sciences Faculty, Shomal University, Amol, Iran ,r.toloee@shomal.ac.ir
2- Department of Exercise Physiology, Sport Sciences Faculty, Shomal University, Amol, Iran ,
Abstract: (1916 Views)
Background: TORC1 protein is an important factor in regulating adipose tissue metabolism. Type 2 diabetes can lead to dysfunction and the development of obesity. Therefore, the aim of the present study was to investigate the effect of eight weeks of high-intensity interval training (HIIT) and endurance on blood glucose and TORC1 protein content in subcutaneous adipose tissue of obese with type 2 diabetes rats.
Methods: In this study, 18 head 2 Sprague-Dawley male rats with a mean weight of 270±30 g were selected. After becoming type 1 diabetic through streptozotocin and Nicotine amide solution, they were randomly divided into 3 groups: 1) HIIT training 2) endurance training and 3) control (6 heads per group). Exercise groups exercised 4 days a week for 8 weeks according to HIIT and endurance training programs. SPSS software version 23, one-way ANOVA and Tukey post hoc test were used to analyze the data.
Result: Eight weeks of HIIT and endurance training resulted in a significant decrease in blood glucose level (p<0.0001) and a significant increase in TORC1 protein content (P<0.0001) compared to the control group.
Conclusion: HIIT and endurance training lowered blood glucose levels and increase TORC1 protein content, which this training can be a suitable and non-invasive treatment to control diabetes and also regulate adipose tissue metabolism in type 2 diabetics who are prone to obesity.
Methods: In this study, 18 head 2 Sprague-Dawley male rats with a mean weight of 270±30 g were selected. After becoming type 1 diabetic through streptozotocin and Nicotine amide solution, they were randomly divided into 3 groups: 1) HIIT training 2) endurance training and 3) control (6 heads per group). Exercise groups exercised 4 days a week for 8 weeks according to HIIT and endurance training programs. SPSS software version 23, one-way ANOVA and Tukey post hoc test were used to analyze the data.
Result: Eight weeks of HIIT and endurance training resulted in a significant decrease in blood glucose level (p<0.0001) and a significant increase in TORC1 protein content (P<0.0001) compared to the control group.
Conclusion: HIIT and endurance training lowered blood glucose levels and increase TORC1 protein content, which this training can be a suitable and non-invasive treatment to control diabetes and also regulate adipose tissue metabolism in type 2 diabetics who are prone to obesity.
Keywords: Blood Glucose, Endurance Training, High-Intensity Interval Training, Subcutaneous Adipose Tissue, TORC1 Protein, Type 2 Diabetes
Type of Study: Research |
Subject:
General
Received: 2021/02/5 | Accepted: 2021/05/1 | Published: 2021/03/30
Received: 2021/02/5 | Accepted: 2021/05/1 | Published: 2021/03/30
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