Volume 21, Issue 2 (7-2021)
ijdld 2021, 21(2): 119-128 |
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Aghaei Bahmanbeglou N, Salboukhi R, Sherafati Moghadam M. The Effect of Protein Kinase-B on FOXO Autophagy Family Proteins (FOXO1 and FOXO3a) Following High Intensity Interval Training in the Left Ventricle of the Heart of Diabetic Rats by Streptozotocin and Nicotinamide. ijdld 2021; 21 (2) :119-128
URL: http://ijdld.tums.ac.ir/article-1-6041-en.html
URL: http://ijdld.tums.ac.ir/article-1-6041-en.html
1- Department of Physical Education and Sport Sciences, Aliabad Katoul Branch, Islamic Azad University, Aliabad Katoul, Iran , nedaghaei@gmail.com
2- Young Researchers and Elites Club, Abadan Branch, Islamic Azad University, Abadan, Iran
3- Department of Sport Sciences, Apadana Institute of Higher Education, Shiraz, Iran
2- Young Researchers and Elites Club, Abadan Branch, Islamic Azad University, Abadan, Iran
3- Department of Sport Sciences, Apadana Institute of Higher Education, Shiraz, Iran
Abstract: (1754 Views)
Background: FOXO family proteins are important factors in autophagy pathway. Protein kinase-B is an important regulator for this family that can be regulated through exercise training. Therefore, the aim of this study is to investigate the effect of protein kinase-B (PKB) on FOXO autophagy family proteins (FOXO1 and FOXO3a) following high intensity interval training (HIIT) in the left ventricle of the heart of diabetic rats by streptozotocin (STZ) and nicotinamide.
Methods: In this experimental study, 12 two-month-old Sprague-Dawley rats with a mean weight of 270±20 g were selected. After type 2 diabetes induction with STZ and Nicotinamide, rats were randomly assigned to two groups, diabetic training (6 heads) and diabetic control (6 heads). The training group trained for 4 days a week in accordance with the training program for 8 weeks. SPSS software version 23 and independent t-test were used to analyze the data. Significance level is considered p≤0.05.
Results: HIIT training resulted in a significant increase in PKB protein content between training and control groups (P=0.0001). In contrast, a significant decrease in protein content of FOXO1 (P=0.003) and FOXO3a (P=0.006) was observed between the training and control groups.
Conclusion: It seems based on the results HIIT with increasing and regulating PKB leads to a decrease and inactivation of FOXO1 and FOXO3a proteins in the hearts of diabetic subjects. Inhibition of these proteins can prevent excessive cardiac autophagy in diabetic subjects.
Methods: In this experimental study, 12 two-month-old Sprague-Dawley rats with a mean weight of 270±20 g were selected. After type 2 diabetes induction with STZ and Nicotinamide, rats were randomly assigned to two groups, diabetic training (6 heads) and diabetic control (6 heads). The training group trained for 4 days a week in accordance with the training program for 8 weeks. SPSS software version 23 and independent t-test were used to analyze the data. Significance level is considered p≤0.05.
Results: HIIT training resulted in a significant increase in PKB protein content between training and control groups (P=0.0001). In contrast, a significant decrease in protein content of FOXO1 (P=0.003) and FOXO3a (P=0.006) was observed between the training and control groups.
Conclusion: It seems based on the results HIIT with increasing and regulating PKB leads to a decrease and inactivation of FOXO1 and FOXO3a proteins in the hearts of diabetic subjects. Inhibition of these proteins can prevent excessive cardiac autophagy in diabetic subjects.
Keywords: High Intensity Interval Training, Heart Muscle, Protein Kinase-B, Protein FOXO1, Protein FOXO3a, Type 2 Diabetes
Type of Study: Research |
Subject:
General
Received: 2021/02/16 | Accepted: 2021/09/4 | Published: 2021/07/1
Received: 2021/02/16 | Accepted: 2021/09/4 | Published: 2021/07/1
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