Volume 21, Issue 5 (1-2022)
ijdld 2022, 21(5): 311-322 |
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Nikseresht F, Bahrami M, Rahmati M. The Effect of Interval Training On G6Pase Expression in Hepatic Tissue, Glucose and Insulin of Obese Rats with Type 2 Diabetic. ijdld 2022; 21 (5) :311-322
URL: http://ijdld.tums.ac.ir/article-1-6088-en.html
URL: http://ijdld.tums.ac.ir/article-1-6088-en.html
1- Department of Physical Education and Sport Sciences, Faculty of Literature and Human Science, Lorestan University, Iran
2- Department of Physical Education and Sport Sciences, Faculty of Literature and Human Science, Lorestan University, Iran ,mostafa_bahr2003@yahoo.com
2- Department of Physical Education and Sport Sciences, Faculty of Literature and Human Science, Lorestan University, Iran ,
Abstract: (1357 Views)
Background: The objective of this experimental study was to determine the effect of 6 weeks of high intensity interval training (HIIT) on G6Pase expression in liver tissue, serum insulin and glucose and insulin resistance in obese rats with type 2 diabetic and compared with non-diabetic obese group.
Methods: 28 male Wistar rats aged 10 weeks (220 ± 10 g) were obesed by 6 weeks of high-fat diet (HFD). Then type 2 diabetes induced in 14 rats by intraperitoneal injection of STZ (30 mg/kg). Finally, the studied rats were divided into 4 same groups: 1) control obese, 2) interval obese, 3) control diabetic, 4) interval diabetic. Interval groups participated in an interval exercise program of 5 sessions per week for 6 weeks consists of 10 repetitions of a 40-second run on the treadmill with 2-minute rest (active rest) between repetitions. 48 hours after the lasting session, fasting levels of glucose, serum insulin and G6Pase expression in liver tissue in all 4 groups were measured and compared with 2 way ANOVA.
Results: Compared with diabetic control groups, HIIT in diabetic group resulted in significant decrease fasting glucose (p= 0.001). HIIT also led to an increase in serum insulin (p= 0.006) without change in G6Pase expression (p= 0.102) compared to the diabetic control group.
Conclusion: Improved glucose response to interval training in type 2 diabetic rats may be rooted in increase insulin without changes in hepatic G6Pase expression. Measurement of activity or expression of other liver enzymes is suggested for general conclusion.
Methods: 28 male Wistar rats aged 10 weeks (220 ± 10 g) were obesed by 6 weeks of high-fat diet (HFD). Then type 2 diabetes induced in 14 rats by intraperitoneal injection of STZ (30 mg/kg). Finally, the studied rats were divided into 4 same groups: 1) control obese, 2) interval obese, 3) control diabetic, 4) interval diabetic. Interval groups participated in an interval exercise program of 5 sessions per week for 6 weeks consists of 10 repetitions of a 40-second run on the treadmill with 2-minute rest (active rest) between repetitions. 48 hours after the lasting session, fasting levels of glucose, serum insulin and G6Pase expression in liver tissue in all 4 groups were measured and compared with 2 way ANOVA.
Results: Compared with diabetic control groups, HIIT in diabetic group resulted in significant decrease fasting glucose (p= 0.001). HIIT also led to an increase in serum insulin (p= 0.006) without change in G6Pase expression (p= 0.102) compared to the diabetic control group.
Conclusion: Improved glucose response to interval training in type 2 diabetic rats may be rooted in increase insulin without changes in hepatic G6Pase expression. Measurement of activity or expression of other liver enzymes is suggested for general conclusion.
Type of Study: Research |
Subject:
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Received: 2021/09/16 | Accepted: 2021/12/18 | Published: 2022/01/30
Received: 2021/09/16 | Accepted: 2021/12/18 | Published: 2022/01/30
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