Volume 22, Issue 3 (9-2022)
ijdld 2022, 22(3): 133-144 |
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Torabi Palat Kaleh G, Sadeghi A, Maleki M J, Abdi A. The Effect of Eight- Week High-Intensity Interval Training on the Expression of Cardiac Angiostatin and Focal adhesion Kinase Proteins at Left Ventricle in Diabetic Rats. ijdld 2022; 22 (3) :133-144
URL: http://ijdld.tums.ac.ir/article-1-6151-en.html
URL: http://ijdld.tums.ac.ir/article-1-6151-en.html
1- Department of Sport Sciences ,Allame Gazvini Institute, Qazvin, Iran
2- Department of Sport Sciences, Faculty of Social Sciences, Imam Khomeini International University, Qazvin, Iran ,sadeghi@soc.ikiu.ac.ir
3- The Sports Medicine Center of Dr. Javad Maleki,Tehran Iran
4- Department of Sport Sciences .Ayatollah Amoli Branch, Islamic Azad University, Amol, Iran
2- Department of Sport Sciences, Faculty of Social Sciences, Imam Khomeini International University, Qazvin, Iran ,
3- The Sports Medicine Center of Dr. Javad Maleki,Tehran Iran
4- Department of Sport Sciences .Ayatollah Amoli Branch, Islamic Azad University, Amol, Iran
Abstract: (1062 Views)
Background: Diabetes can increase cardiovascular disease by altering the equilibrium between angiogenic stimulants and inhibitors of angiogenesis. In this study, we investigated the effect of High-Intensity Interval Training (HIIT) on angiostatin and focal adhesion kinase (FAK-1) in left ventricle cardiomyocytes in diabetic rats.
Methods: In this experimental study, 24 male Wistar rats were randomly divided into three equal groups (n=8): Control-Normal (C), Diabetes (D), and Diabetes-training (D+T). Diabetes was induced by the injection of streptozotocin in male rats. The Training group has performed a HIIT program on a motor-driven treadmill for eight weeks. At the end of eight weeks-- heart tissue samples were collected. Data were analyzed using ANOVA and Tukey post hoc at P<0.05.
Results: The results showed that induction of diabetes increased the expression of angiostatin (P=0.006), and serum glucose (P=0.001) and decreased FAK-1 (P=0.001). HIIT significantly reduced the level of angiostatin (P=0.006) and glucose (P=0.001) in diabetic rats. There was also a significant increase in FAK-1 in the D+T group (P=0.001).
Conclusion: HIIT decreased the protein expression of angiostatin and glucose and increased FAK-1 in cardiomyocytes. HIIT seems to reduce the vascular complications of diabetes in rats by altering these parameters that affect angiogenesis and blood glucose.
Methods: In this experimental study, 24 male Wistar rats were randomly divided into three equal groups (n=8): Control-Normal (C), Diabetes (D), and Diabetes-training (D+T). Diabetes was induced by the injection of streptozotocin in male rats. The Training group has performed a HIIT program on a motor-driven treadmill for eight weeks. At the end of eight weeks-- heart tissue samples were collected. Data were analyzed using ANOVA and Tukey post hoc at P<0.05.
Results: The results showed that induction of diabetes increased the expression of angiostatin (P=0.006), and serum glucose (P=0.001) and decreased FAK-1 (P=0.001). HIIT significantly reduced the level of angiostatin (P=0.006) and glucose (P=0.001) in diabetic rats. There was also a significant increase in FAK-1 in the D+T group (P=0.001).
Conclusion: HIIT decreased the protein expression of angiostatin and glucose and increased FAK-1 in cardiomyocytes. HIIT seems to reduce the vascular complications of diabetes in rats by altering these parameters that affect angiogenesis and blood glucose.
Type of Study: Research |
Subject:
Special
Received: 2022/05/16 | Accepted: 2022/09/14 | Published: 2022/09/1
Received: 2022/05/16 | Accepted: 2022/09/14 | Published: 2022/09/1
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