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ijdld 2023, 23(1): 13-23 |
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Rangraz tabatabaei M, Nikbakht M, Ranjbar R, Daryanoosh F, Ghanbarzadeh M. Effect of Eight Weeks High Intensity Interval Training (HIIT) on Asprosin, Lipid Profile and Insulin Resistance in Type 2 Diabetic Male Rats. ijdld 2023; 23 (1) :13-23
URL: http://ijdld.tums.ac.ir/article-1-6197-en.html
URL: http://ijdld.tums.ac.ir/article-1-6197-en.html
Mahboobeh Rangraz tabatabaei * 
1, Masoud Nikbakht2 , Rohollah Ranjbar2 , Farhad Daryanoosh3 , Mohsen Ghanbarzadeh2
1, Masoud Nikbakht2 , Rohollah Ranjbar2 , Farhad Daryanoosh3 , Mohsen Ghanbarzadeh2
1- Department of exercise physiology, Faculty of Sport Sciences,Shahid chamran university of Ahvaz, Ahvaz, Iran , mah.r.taba@gmail.com
2- Department of exercise physiology, Faculty of Sport Sciences,Shahid chamran university of Ahvaz, Ahvaz, Iran
3- Department of Sport Sciences, School of Education and Psychology, Shiraz university, Shiraz, Iran
2- Department of exercise physiology, Faculty of Sport Sciences,Shahid chamran university of Ahvaz, Ahvaz, Iran
3- Department of Sport Sciences, School of Education and Psychology, Shiraz university, Shiraz, Iran
Abstract: (1033 Views)
Background: The release of adipokines from adipose tissue depots plays a key role in regulating metabolic homeostasis and several other physiological processes, including diabetes, obesity, and vascular diseases. This study investigated the effect of eight weeks of high intensity interval training (HIIT) on asprosin, lipid profile and insulin resistance in type 2 diabetic male rats.
Methods: 24 male Sprague Dawley rats were randomly divided into four equal groups: control (C), control traning (C+T), diabet (D) and diabet traning (D+T). Diabetes was induced by the combined method of high fat diet and low dose strepotozocin injection. The traning group performed the HIIT program on the treadmill for eight weeks. Data were analyzed using one-way ANOVA and bonferroni post hoc test at a significance level of P<0.05.
Results: The results showed increased plasma asprosin in D group compared to C (P=0.0001) and decreased in C+T group compared to C (P=0.03) and D+T group compared to D (P=0.04). There was no significant difference in HOMA-IR between the C and C+T group (P=0.9) but decreased in D+T compared to D (P=0.0001). HDL increased in D+T group compared to the D (P=0.0001) and decreased TG and LDL (P=0.001). There was no significant difference between TG and LDL in the C group compared to the C+T, but HDL increased in C+T (P=0.01).
Conclusion: Plasma asprosin increases in rats with type 2 diabetes and HIIT can reduce the complications of diabetes by improved lipid profile and reduce asprosin and insulin resistance.
Methods: 24 male Sprague Dawley rats were randomly divided into four equal groups: control (C), control traning (C+T), diabet (D) and diabet traning (D+T). Diabetes was induced by the combined method of high fat diet and low dose strepotozocin injection. The traning group performed the HIIT program on the treadmill for eight weeks. Data were analyzed using one-way ANOVA and bonferroni post hoc test at a significance level of P<0.05.
Results: The results showed increased plasma asprosin in D group compared to C (P=0.0001) and decreased in C+T group compared to C (P=0.03) and D+T group compared to D (P=0.04). There was no significant difference in HOMA-IR between the C and C+T group (P=0.9) but decreased in D+T compared to D (P=0.0001). HDL increased in D+T group compared to the D (P=0.0001) and decreased TG and LDL (P=0.001). There was no significant difference between TG and LDL in the C group compared to the C+T, but HDL increased in C+T (P=0.01).
Conclusion: Plasma asprosin increases in rats with type 2 diabetes and HIIT can reduce the complications of diabetes by improved lipid profile and reduce asprosin and insulin resistance.
Keywords: High-Intensity Interval Training, Asprosin, Insulin Resistance, Lipid Profile, Type 2 Diabetes
Type of Study: Research |
Subject:
Special
Received: 2022/11/27 | Accepted: 2023/02/1 | Published: 2023/05/31
Received: 2022/11/27 | Accepted: 2023/02/1 | Published: 2023/05/31
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