Volume 23, Issue 2 (5-2023)
ijdld 2023, 23(2): 103-113 |
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Salboukhi R, Azizi M, Zavari A, Espandar N. The Effect of Combination of Continuous Exercise and Resveratrol Supplementation on Foxo-1 and Atrogin-1 Gene Expression in Cardiomyocytes of Diabetic Male Wistar Rats. ijdld 2023; 23 (2) :103-113
URL: http://ijdld.tums.ac.ir/article-1-6205-en.html
URL: http://ijdld.tums.ac.ir/article-1-6205-en.html
1- Abadan University of Medical Sciences, Abadan, Iran
2- Department of Physical Education And Sport, Abadan Branch, Islamic Azad University, Abadan, Iran ,scienceinsport@yahoo.com
3- Department of Exercise Physiology, Faculty of Sport Sciences, Urmia University, Urmia, Iran
2- Department of Physical Education And Sport, Abadan Branch, Islamic Azad University, Abadan, Iran ,
3- Department of Exercise Physiology, Faculty of Sport Sciences, Urmia University, Urmia, Iran
Abstract: (697 Views)
Background: Expression of FoxO transcription factors whould increase during certain forms of atrophy. In a dephosphorylated state, FoxOs participate in ubiquitin-mediated proteasomal degradation through the transcriptional activation of E3-ubiquitin ligases such as MAFbx/atrogin-1. Therefore, the study aimed to determine the effect of combination of continuous exercise and resveratrol supplementation on foxo-1 and Atrogin-1 gene expression in the left ventricular tissue of male Wistar rats.
Methods: In this study, 25 male Wistar rats with 180-250 g weight were randomly classified into 5 groups, including healthy control (n=5), diabetic control (n=5), diabetic resveratrol (n=5), diabetic-continuous exercise (n=5), and resveratrol+ continuous exercise+ diabetes (n=5). After inducing diabetes by intraperitoneal injection of streptozotocin, animals in expremental groups were carried out an 8-week exercise program on a treadmill with 60-75% Vo2max. One-way ANOVA and Tukey test with statistical level (P<0.05) was used to compare the differences between groups.
Results: The results showed that gene expression of Atrodin-1 were significantly markedly in the ARDM group compared to the DM group (P= 0.02) but the gene expression of foxo-1 only was significantly changed (P= 0.001) in ARDM group to compared with the other groups (P>0.05).
Conclusion: It seems that the Foxo1 gene expression fluctuations along with the significant decrease in the expression of the atherogen-1 gene can be improving the diabetic heart as a non-pharmacological method.
Methods: In this study, 25 male Wistar rats with 180-250 g weight were randomly classified into 5 groups, including healthy control (n=5), diabetic control (n=5), diabetic resveratrol (n=5), diabetic-continuous exercise (n=5), and resveratrol+ continuous exercise+ diabetes (n=5). After inducing diabetes by intraperitoneal injection of streptozotocin, animals in expremental groups were carried out an 8-week exercise program on a treadmill with 60-75% Vo2max. One-way ANOVA and Tukey test with statistical level (P<0.05) was used to compare the differences between groups.
Results: The results showed that gene expression of Atrodin-1 were significantly markedly in the ARDM group compared to the DM group (P= 0.02) but the gene expression of foxo-1 only was significantly changed (P= 0.001) in ARDM group to compared with the other groups (P>0.05).
Conclusion: It seems that the Foxo1 gene expression fluctuations along with the significant decrease in the expression of the atherogen-1 gene can be improving the diabetic heart as a non-pharmacological method.
Type of Study: Research |
Subject:
Special
Received: 2023/01/2 | Accepted: 2023/05/6 | Published: 2023/09/13
Received: 2023/01/2 | Accepted: 2023/05/6 | Published: 2023/09/13
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