Volume 23, Issue 4 (11-2023)
ijdld 2023, 23(4): 236-244 |
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Alizadeh Palavani H, Yaghmaei M, Mirzaee Moghamir S, Salboukhi R. The Effect of High-Intensity Interval Training on the Amount of BECLIN1/2 Family Autophagy Proteins in the Left Ventricle of the Heart in Rats with Type 1 Diabetes. ijdld 2023; 23 (4) :236-244
URL: http://ijdld.tums.ac.ir/article-1-6234-en.html
URL: http://ijdld.tums.ac.ir/article-1-6234-en.html
1- Department of Physical Education, Farhangian University, Tehran, Iran , ha.alizadeh@cfu.ac.ir
2- Behbahan Khatam Alanbia University of Technology, Behbahan, Iran
3- Department of exercise physiology, Faculty of Sports Sciences, Kharazmi University, Tehran, Iran
4- Abadan University of Medical Sciences, Abadan, Iran
2- Behbahan Khatam Alanbia University of Technology, Behbahan, Iran
3- Department of exercise physiology, Faculty of Sports Sciences, Kharazmi University, Tehran, Iran
4- Abadan University of Medical Sciences, Abadan, Iran
Abstract: (648 Views)
Background: Several proteins regulate the autophagy pathway, and one of the most important regulators is the BECLIN family proteins. Therefore, this research aims to investigate the effect of high-intensity interval training on the amount of BECLIN1/2 family autophagy proteins in the left ventricle of the heart of rats with type 1 diabetes.
Methods: In this experimental study, 18 three-month-old male Sprague Dawley rats with an average weight of 300±20 grams were selected. 12 rats were diagnosed with type 1 diabetes through intraperitoneal injection of streptozotocin solution. These rats were randomly divided into two groups, diabetic exercise, and diabetic control; A healthy control group was also considered; The HIIT was performed for 6 weeks and 4 sessions each week including 5 bursts of 4 minutes with an intensity equal to 85-95% of the maximum speed and 3-minute active rest periods with an intensity equal to 50-60% of the maximum speed. Data analysis was done through one-way ANOVA and Tukey's post hoc tests in SPSS version 26 software. A significance level of 0.05 was considered.
Results: The intracellular content of BECLIN1 and BECLIN2 protein showed a significant decrease between the research groups in the left ventricle of the heart after six weeks of HIIT (p=0.0001).
Conclusion: It seems that BECLIN family proteins are decreased by HIIT and this can decrease the autophagy mechanism in cardiac cells.
Methods: In this experimental study, 18 three-month-old male Sprague Dawley rats with an average weight of 300±20 grams were selected. 12 rats were diagnosed with type 1 diabetes through intraperitoneal injection of streptozotocin solution. These rats were randomly divided into two groups, diabetic exercise, and diabetic control; A healthy control group was also considered; The HIIT was performed for 6 weeks and 4 sessions each week including 5 bursts of 4 minutes with an intensity equal to 85-95% of the maximum speed and 3-minute active rest periods with an intensity equal to 50-60% of the maximum speed. Data analysis was done through one-way ANOVA and Tukey's post hoc tests in SPSS version 26 software. A significance level of 0.05 was considered.
Results: The intracellular content of BECLIN1 and BECLIN2 protein showed a significant decrease between the research groups in the left ventricle of the heart after six weeks of HIIT (p=0.0001).
Conclusion: It seems that BECLIN family proteins are decreased by HIIT and this can decrease the autophagy mechanism in cardiac cells.
Keywords: BECLIN 1/2 Proteins, High-Intensity Interval Training, Type 1 Diabetes, Left Ventricle Heart
Type of Study: Research |
Subject:
Special
Received: 2023/04/23 | Accepted: 2023/07/4 | Published: 2023/11/1
Received: 2023/04/23 | Accepted: 2023/07/4 | Published: 2023/11/1
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