Volume 24, Issue 4 (10-2024)                   ijdld 2024, 24(4): 199-209 | Back to browse issues page

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Zolfi H R, Shakib A, Zarei M, Farhangi N. Changes in Expression of miR-17 Gene and Oxidative Stress Indices in Overweight and Obese Women Following High-Intensity Functional Training. ijdld 2024; 24 (4) :199-209
URL: http://ijdld.tums.ac.ir/article-1-6320-en.html
1- Department of Physical Education and Sport Science, National University of Skills (NUS), Tehran, Iran
2- Department of Exercise Physiology, Faculty of Physical Education and Sport Sciences, University of Tabriz, Tabriz, Iran
3- Department of Physical Education and Sport Sciences, Faculty of Literature and Humanities, University of Neyshabur, Neyshabur, Iran , Mehdizarei@neyshabur.ac.ir
Abstract:   (524 Views)
Background: The effects of regular exercise on miRNA profile and oxidative stress indices are less known. The aim of this study was to investigate the changes in expression of  miR-17 and oxidative stress indices in overweight and obese women following high-intensity functional training.
Methods: In this semi-experimental study, 22 overweight and obese women were randomly divided into two groups of high-intensity functional training (n= 10) and control (n= 12). The subjects of the training group performed high-intensity functional exercises 3 times a week for 8 weeks and intensity of rating of perceived exertion7. Before and after 8 weeks, blood samples were taken to measure expression of miR-17 gene, malondialdehyde (MDA), superoxide dismutase, glutathione peroxidase (GPx) and total antioxidant capacity (TAC). Analysis of covariance test was used to analyze the data.
Results: After eight weeks of high-intensity functional training, expression of miR-17 in the experimental group significantly decreased compared to the control group (P= 0.001). After eight weeks of high-intensity functional training, TAC (P= 0.0001), GPX (P= 0.007) and SOD (P= 0.001) increased significantly in the experimental group compared to the control group. No significant change was observed in MDA (P= 0.778).
Conclusion: The results of the present study showed that eight weeks of high-intensity functional training may lead to the reduction of miR-17 expression and the improvement of oxidative stress indices and antioxidant enzymes, which may be effective in improving metabolic indices and obesity complications.
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Type of Study: Research | Subject: General
Received: 2023/12/27 | Accepted: 2024/03/10 | Published: 2024/10/31

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