Volume 24, Issue 3 (7-2024)
ijdld 2024, 24(3): 170-178 |
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Parsayyrad A, Khorshidi D, kiani F. The Effect of High Intensity Interval Training on Hepatic TCF7L2 Expression and Glycemic Control in Type 2 Diabetes Rats. ijdld 2024; 24 (3) :170-178
URL: http://ijdld.tums.ac.ir/article-1-6335-en.html
URL: http://ijdld.tums.ac.ir/article-1-6335-en.html
1- Department of Physical Education and Sport Sciences, Faculty of Humanities, Saveh Branch, Islamic Azad University, Saveh, Iran
2- Department of Physical Education and Sport Sciences, Faculty of Humanities, Saveh Branch, Islamic Azad University, Saveh, Iran ,khorshididavood@yahoo.com
2- Department of Physical Education and Sport Sciences, Faculty of Humanities, Saveh Branch, Islamic Azad University, Saveh, Iran ,
Abstract: (401 Views)
Background: Transcription factor 7-like 2 (TCF7L2) is one of the strongest genetic risk factors associated with type 2 diabetes mellitus (T2DM). The purpose of this study was to investigate the effect of 10 weeks of high intensity interval training (HIIT) on hepatic TCF7L2 expression in T2DM rats.
Methods: In this experimental study, fourteen males Wistar rats with T2DM induced by streptozotocin-nicotinamide injection were randomly divided into exercise (n=7) and control (n=7) groups. The exercise group performed the HIIT protocol on a treadmill for 10 weeks and 5 days per week. Hepatic TCF7L2 expression, blood glucose level, hemoglobin A1c (HbA1c), insulin and insulin resistance were measured 48 hours after the last training session. Data were analyzed by independent T test at P< 0.05.
Results: Hepatic TCF7L2 expression and serum insulin were significantly higher in the exercise group compared to the control group (P˂0.05). Blood glucose level, HbA1c and insulin resistance were significantly lower in the exercise group than in the control group (P˂0.05).
Conclusion: Based on these findings, it seems that the improved glycemic control in response to HIIT is partially dependent on the inhibition of gluconeogenesis caused by increased hepatic TCF7L2 expression.
Methods: In this experimental study, fourteen males Wistar rats with T2DM induced by streptozotocin-nicotinamide injection were randomly divided into exercise (n=7) and control (n=7) groups. The exercise group performed the HIIT protocol on a treadmill for 10 weeks and 5 days per week. Hepatic TCF7L2 expression, blood glucose level, hemoglobin A1c (HbA1c), insulin and insulin resistance were measured 48 hours after the last training session. Data were analyzed by independent T test at P< 0.05.
Results: Hepatic TCF7L2 expression and serum insulin were significantly higher in the exercise group compared to the control group (P˂0.05). Blood glucose level, HbA1c and insulin resistance were significantly lower in the exercise group than in the control group (P˂0.05).
Conclusion: Based on these findings, it seems that the improved glycemic control in response to HIIT is partially dependent on the inhibition of gluconeogenesis caused by increased hepatic TCF7L2 expression.
Type of Study: Research |
Subject:
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Received: 2024/02/19 | Accepted: 2024/02/29 | Published: 2024/07/31
Received: 2024/02/19 | Accepted: 2024/02/29 | Published: 2024/07/31
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