1- Department of Physical Education and Sports Sciences, Science and Research Branch, Islamic Azad University, Tehran, Iran
2- Department of Physical Education and Sports Sciences, Science and Research Branch, Islamic Azad University, Tehran, Iran ,abednazari@gmail.com
2- Department of Physical Education and Sports Sciences, Science and Research Branch, Islamic Azad University, Tehran, Iran ,
Abstract: (92 Views)
The aim of the present study was to study the changes in GLUT4 gene expression in soleus muscle tissue and insulin resistance index after HIIT and royal jelly in type 2 diabetic obese rats. Methods: The statistical sample of the present study was 36 obese diabetic male rats. After 20 weeks of feeding with a high-fat diet, the rats became diabetic by intraperitoneal injection of 25 mg/kg of STZ. Diabetic rats were grouped into 4 groups: control, intermittent exercise, royal Jelly, HIIT-Jelly. Eight weeks HIIT, five sessions per week with 2-minute HIIT of 80 to 90% and one-minute rest interval were performed. Royal jelly was given by gavage with a dose of 100 mg/kg before training. Findings: Data analysis using one-way and two-way analysis of variance and post-hoc test showed that compared to the control group, HIIT led to a significant decrease in glucose and insulin resistance index HIIT and royal jelly led to a significant increase in GLUT4 gene expression in soleus muscle compared to the control group (P=0.001). Conclusion: HIIT and royal jelly were effective in reducing insulin resistance index and expression of genes effective in glucose consumption in soleus muscle. Also, HIIT and royal jelly led to an increase in GLUT4 gene expression in the soleus muscle compared to the control group, which is important in glucose consumption in diabetics.
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