Volume 25, Issue 2 (7-2025)
ijdld 2025, 25(2): 85-100 |
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Saremi A, Zafarmand O. The Effect of High-Intensity Interval Training on Plasma Irisin Levels and Glycemic Indices in Obese and Type 2 Diabetic People: A Systematic Review and Meta-Analysis. ijdld 2025; 25 (2) :85-100
URL: http://ijdld.tums.ac.ir/article-1-6415-en.html
URL: http://ijdld.tums.ac.ir/article-1-6415-en.html
1- Department of Exercise Physiology, Faculty of Sport Sciences, Arak University, Arak, Iran
2- Department of Physical Education and Sports Sciences, School of Humanities, University of Yasouj, Yasouj, Iran ,OMIDZAFARMAND2202@GMAIL.COM
2- Department of Physical Education and Sports Sciences, School of Humanities, University of Yasouj, Yasouj, Iran ,
Abstract: (1381 Views)
Background: Irisine is a new myokine that is released from the membrane protein fndc5 and has positive effects on metabolism. The aim of the present study was to investigate the effect of high-intensity interval training on plasma irisin levels and glycemic indices in obese and type 2 diabetic people.
Methods: A systematic search of published English and Persian articles was conducted from PubMed, Web of Science, Scopus, SID, and Magiran databases up to 20 November 2024. The mean difference and 95% confidence interval (CI) were calculated using a random-effects model. Heterogeneity was assessed using the (I2) test and publication bias was assessed using visual analysis of funnel plots and Egger's test.
Results: A total of 11 studies and 264 obese and type 2 diabetic subjects were included in the present meta-analysis. The results showed that high-intensity interval training significantly increased irisin [WMD = 1.448 ng/ml (2.280 to 0.616), P= 0.001], significantly decreased glucose [WMD = -12.127 mg/dl (-24.180 to -0.074), P= 0.049] and insulin resistance [WMD= -1.275 (-0.567 to -1.983), P= 0.001] compared to the control group in obese and type 2 diabetic subjects. While insulin [WMD= -0.249Iu/ml (3.402 to -3.901), P= 0.894] was not significantly reduced.
Conclusion: Overall, the findings of the present meta-analysis indicate that high-intensity interval training plays an effective role in irisin, glucose, insulin, and insulin resistance to high-intensity interval training. High-intensity interval training increases irisin, decreases glucose, insulin, and insulin resistance in obese and diabetic individuals. Lifestyle modification and exercise training are preferred treatment strategy in obese and type 2 diabetic people.
Methods: A systematic search of published English and Persian articles was conducted from PubMed, Web of Science, Scopus, SID, and Magiran databases up to 20 November 2024. The mean difference and 95% confidence interval (CI) were calculated using a random-effects model. Heterogeneity was assessed using the (I2) test and publication bias was assessed using visual analysis of funnel plots and Egger's test.
Results: A total of 11 studies and 264 obese and type 2 diabetic subjects were included in the present meta-analysis. The results showed that high-intensity interval training significantly increased irisin [WMD = 1.448 ng/ml (2.280 to 0.616), P= 0.001], significantly decreased glucose [WMD = -12.127 mg/dl (-24.180 to -0.074), P= 0.049] and insulin resistance [WMD= -1.275 (-0.567 to -1.983), P= 0.001] compared to the control group in obese and type 2 diabetic subjects. While insulin [WMD= -0.249Iu/ml (3.402 to -3.901), P= 0.894] was not significantly reduced.
Conclusion: Overall, the findings of the present meta-analysis indicate that high-intensity interval training plays an effective role in irisin, glucose, insulin, and insulin resistance to high-intensity interval training. High-intensity interval training increases irisin, decreases glucose, insulin, and insulin resistance in obese and diabetic individuals. Lifestyle modification and exercise training are preferred treatment strategy in obese and type 2 diabetic people.
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