Volume 25, Issue 6 (1-2026)
ijdld 2026, 25(6): 512-523 |
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Mohseni S, Mohajeri-Tehrani M, Pejman Sani M. Association of Blood Glucose Variability with Microvascular and Macrovascular Complications of Diabetes: A Review Study. ijdld 2026; 25 (6) :512-523
URL: http://ijdld.tums.ac.ir/article-1-6531-en.html
URL: http://ijdld.tums.ac.ir/article-1-6531-en.html
1- Endocrinology and Metabolism Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran
2- Endocrinology and Metabolism Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran ,mpsani@sina.tums.ac.ir
2- Endocrinology and Metabolism Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran ,
Abstract: (395 Views)
Blood glucose variability, defined as variations in blood glucose levels over time, is increasingly recognized as a significant factor in the pathology of diabetes complications. While chronic hyperglycemia has been linked to microvascular complications (retinopathy, nephropathy, and neuropathy) and macrovascular complications (coronary artery disease, stroke, and peripheral artery disease), emerging evidence suggests that glucose variability is an independent risk factor for these conditions. This review examined the relationship between blood glucose variability and the development of microvascular and macrovascular complications in diabetes, highlighting the underlying mechanisms, clinical implications, and therapeutic approaches.
Keywords: Diabetes mellitus, Blood glucose variability, Microvascular complications, Macrovascular complications
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