Volume 25, Issue 6 (1-2026)
ijdld 2026, 25(6): 555-564 |
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Karimzadeh P, Khazaeli Najafabadi M, Sharghi S A, Karimi Birgani F, Asadollahpour E, Parichehreh-Dizaji S, et al . Endocrine Neoplasm Tumor Biobank as a Platform for Advancing Cancer Research: A Framework for Design, Collection, Processing, and Storage. ijdld 2026; 25 (6) :555-564
URL: http://ijdld.tums.ac.ir/article-1-6536-en.html
URL: http://ijdld.tums.ac.ir/article-1-6536-en.html
Parisa Karimzadeh1 
, Mahdis Khazaeli Najafabadi2 , Sina A Sharghi3 , Farzaneh Karimi Birgani1 , Effat Asadollahpour1 , Somayeh Parichehreh-Dizaji1 , Mahnaz Pejman Sani1 , Sayed Mahmoud Sajjadi-Jazi1 , Mahmood Naderi4 , Hilda Samimi1 , Shirzad Nasiri5 , Seyed Mohammad Tavangar2 , Bagher Larijani1 , Vahid Haghpanah *6
, Mahdis Khazaeli Najafabadi2 , Sina A Sharghi3 , Farzaneh Karimi Birgani1 , Effat Asadollahpour1 , Somayeh Parichehreh-Dizaji1 , Mahnaz Pejman Sani1 , Sayed Mahmoud Sajjadi-Jazi1 , Mahmood Naderi4 , Hilda Samimi1 , Shirzad Nasiri5 , Seyed Mohammad Tavangar2 , Bagher Larijani1 , Vahid Haghpanah *6
1- Endocrinology and Metabolism Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran
2- Department of Pathology, Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran
3- Department of Surgery, Emam Ali Hospital, Alborz University of Medical Sciences, Karaj, Iran
4- Digestive Oncology Research Center, Digestive Diseases Research Institute, Tehran University of Medical Sciences, Tehran, Iran
5- Department of Surgery, Shariati Hospital, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
6- Endocrinology and Metabolism Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran ,vhaghpanah@tums.ac.ir
2- Department of Pathology, Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran
3- Department of Surgery, Emam Ali Hospital, Alborz University of Medical Sciences, Karaj, Iran
4- Digestive Oncology Research Center, Digestive Diseases Research Institute, Tehran University of Medical Sciences, Tehran, Iran
5- Department of Surgery, Shariati Hospital, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
6- Endocrinology and Metabolism Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran ,
Abstract: (323 Views)
Background: Biobanks are biological repositories that collect, process, store, and distribute human biological samples. Among them, tumor banks play a central role in biomedical research. The overall goal of a tumor bank is to collect cancerous and normal samples under standardized conditions for basic, clinical, or applied research.
Methods: Tumor samples from patients with endocrine neoplasms were collected from excess tissue samples not required for diagnostic purposes after surgery in the surgical department of Dr. Shariati Hospital, Tehran, Iran. In addition, relevant biological samples such as serum, plasma and DNA were collected in parallel. Prior to sampling, informed consent was obtained from the patients and a questionnaire was completed. After rapid freezing with isopentane, tissue samples were stored in a liquid nitrogen tank, while other biological materials, such as serum, were stored in a -80°C freezer.
Results: Tissue, plasma, serum, and DNA samples collected from patients with endocrine neoplasms were stored in separate barcoded storage boxes in the biobank and were made available to researchers.
Conclusion: The use of bioproducts in domestic research and international networks has strengthened research collaborations through supporting the collection and distribution of tissues, especially cancer tissues. This trend plays an important role in facilitating basic and applied research in various fields of cancer, including molecular biology, immunology, genetics and pharmacology, and will pave the way for scientific advances and therapeutic innovations.
Methods: Tumor samples from patients with endocrine neoplasms were collected from excess tissue samples not required for diagnostic purposes after surgery in the surgical department of Dr. Shariati Hospital, Tehran, Iran. In addition, relevant biological samples such as serum, plasma and DNA were collected in parallel. Prior to sampling, informed consent was obtained from the patients and a questionnaire was completed. After rapid freezing with isopentane, tissue samples were stored in a liquid nitrogen tank, while other biological materials, such as serum, were stored in a -80°C freezer.
Results: Tissue, plasma, serum, and DNA samples collected from patients with endocrine neoplasms were stored in separate barcoded storage boxes in the biobank and were made available to researchers.
Conclusion: The use of bioproducts in domestic research and international networks has strengthened research collaborations through supporting the collection and distribution of tissues, especially cancer tissues. This trend plays an important role in facilitating basic and applied research in various fields of cancer, including molecular biology, immunology, genetics and pharmacology, and will pave the way for scientific advances and therapeutic innovations.
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