Showing 2 results for Abbassi Daloii
Nadiyeh Mohammadpour, Zaher Etemad, Khalid Mohammadzade, Asieh Abbassi Daloii,
Volume 20, Issue 3 (2-2021)
Abstract
Background: The hepatokines are now considered potential targets for the treatment of type 2 diabetes disorders. The aim of this study was to investigate the effect of 12 weeks combined training with Canagliflozin on some hepatokines in type 2 diabetic men.
Methods: In this quasi-experimental study, 44 men with type 2 diabetes (Mean age 33.2 ± 4.5 years, body mass index 27.3±3.0) from Tehran city in 2019 were randomly divided into four groups (n=11) of control, drug, exercise and exercise-drug groups. Combined training was performed 3 sessions per week, 45 minutes for 12 weeks. Subjects were given 200 mg of canagliflozin for 12 weeks. Blood samples and anthropometric characteristics were obtained before and 24 hours after the intervention at 12-hour fasting. Data were analyzed using two-way ANOVA with repeated measures, t-test and Bonferroni post hoc test at P<0.05.
Results: The results showed that 12 weeks of exercise with Canagliflozin intervention significantly reduced angiopoietin-3 and angiopoietin-4, FGF-21 and HFREP-1 levels in type 2 diabetic men (P=0.001). Also, after the intervention of exercise with Canagliflozin, levels of angiopoietin-3, angiopoietin-4, FGF-21, and HFREP-1 were significantly lower than the pre-test (P<0.001).
Conclusion: According to the results of research, it is possible that intervention of exercise with Canagliflozin can help treat of disorders due to type 2 diabetes by reducing hepatokines.
Mahdieh Ghasemi, Ahmad Abdi, Asieh Abbassi Daloii,
Volume 22, Issue 5 (12-2022)
Abstract
Background: Inflammation plays a critical role in the promotion of hepatocyte damage and liver fibrosis. In recent years the protective role of exercise and royal jelly (RJ), has been suggested for metabolic and inflammatory disorders. In this study, we aimed to evaluate the effects of aerobic training (AT) and RJ on pro-inflammatory markers in a rat's model of a high-fat diet (HFD).
Methods: In this experimental study, 45 male rats were randomly divided into five groups (Each group: n=9): Normal Diet (ND), High-Fat Diet (HFD), High-Fat Diet +Training (HFDT), High-Fat Diet + Royal Jelly (HFDRJ), and High-Fat Diet +Training + Royal Jelly (HFDTRJ). The supplement groups received 100 mg of royal jelly (kg/body weight) diluted in distilled water orally during the intervention period. The aerobic exercise program included treadmill running with an intensity of 50-60% oxygen consumption (VO2max), 5 days/week for 8 weeks.
Results: HFD increased hepatic NF-κB (p=0.006), TNF-α (p=0.0001) and IL-1β (p=0.0001). AT, RJ as well as the combination of AT with RJ decreased NF-κB, TNF-α and IL-1β (p≤0.05). Decrease in NF-κB, TNF-α and IL-1β were significant in HFDTRJ group compared to HFDT and HFDRJ groups (p≤0.05).
Conclusion: The combination of AT and RJ may decrease inflammatory markers and improve HFD-induced hepatic steatosis by reducing the expression of NF-κB, TNF-α, and IL-1β.
