Showing 9 results for Afshar
Bagher Larijani, Mohammad Hasan Bastan Hagh, Mohammad Pajouhi, Mojgan Afshari, Mansoureh Khani, Masoumeh Shagareyan,
Volume 1, Issue 1 (18 2001)
Abstract
Background: Diabetes mellitus is a common chronic disorder with multiple disabling long- and shorter-term complications, the majority of which can be controlled if not prevented. The management of diabetic patients is a major drain on both health budgets and time.
Methods: We reviewed the records of 101 patients with diabetic foot ulcer, who had received treatment at either Doctor Shariati or Imam Khomeini hospital.
Results: Out of 101 patients (56.4% male and 43.6% female) with diabetic foot ulcer, 34.7% had eventually undergone amputation.
Conclusion: Our findings highlight the need for control and prevention programmes aimed at reducing the risk factors for and complications of diabetic foot ulcer.
Maryam Razaghi-Azar, Nazanin Noori, Kamran Afsharian,
Volume 4, Issue 3 (17 2005)
Abstract
Background: The importance of feed controlling has been proved in metabolic control of diabetic patients. An appropriate metabolic control prevents later complications. Patients with diabetes mellitus are deprived from eating sweat foods. Considering the effect of different carbohydrates on blood sugar, physicians and patients confront a lot of questions about eating these foods. The aim of this study was to compare the effect of sugar cube and Date consumption on blood sugar in patients with type 1 diabetes.
Methods: As a clinical-trial, we selected 20 patients with type I diabetes mellitus sequentially. They were divided into two groups with 10 subjects in each group. The patient’s blood sugar was measured in 2 days with one week interval, before and after eating a Date (10gr) and a sugar cube (5gr). We measured blood sugar at 30, 60, 90 and 120 minutes after consumption. Data analysis was performed by SPSS software version 11, and the results were compared by paired t test.
Results: There was no significant difference between the blood sugar after eating Date and sugar cube. We also compared the surface under the curve of blood sugar after eating date and sugar cube in 2 hours, which was 1619.4 ± 614 mg.min/dL and 1572 ± 967 mg.min/dL for sugar cube and Date respectively, which the difference was not significant.
Conclusion: Rising in blood sugar after Date consumption has not significant difference in comparison with sugar cube consumption in patients with type I diabetes. So, eating Date in diabetic patients is not preferable to eating sugar cube.
Gholamabbas Mohammady, Maryam Darabi-Amin, Mohammad Javad Sabet-Jahromi1, Reza Malek Puor -Afshar, Hassan Sheibani, Mohammad Nasry,
Volume 6, Issue 4 (17 2007)
Abstract
Background: Atherosclerosis is the leading cause of mortality in the developed and some developing countries. Some people believe that opium abuse has beneficial effects for reducing blood lipids and atherosclerosis prevention. In this study, the effect of oral opium addiction on lipid profile and atherogenesis in normal and hypercholesterolemic rabbits was studied.
Methods: Thirty two male Newzeland White rabbits were used in this study. They were divided into four groups including control, hypercholesterolemic, addicted, and hypercholesterolemic addicted and were studied for three months. The blood samples were obtained and lipid profile was determined at the beginning of the study and at the end of every month thereafter. After 90 days aorta was removed to assess for lesion formation.
Results: The levels of cholesterol, triglyceride (TG), high density lipoprotein-cholesterol (HDL-C), low density lipoprotein-cholesterol (LDL-C), and atherogenic index (total cholesterol/HDL-C) in the hypercholesterolemic and hypercholesterolemic addicted rabbits were increased significantly (P<0.001). These increases in lipids and aorta lesion areas were higher in hypercholesterolemic addicted group than hypercholesterolemic group.
Conclusion: These findings suggest that oral opium abuse affects cholesterol metabolism and depending on the dietary condition can have an aggravating effect on atherosclerosis. The protective effect of morphine on cardiac disease is not probably through the modulation of lipid metabolism.
Mehdi Zarei, Mohamadreza Hamedinia, Amirhossein Haghighi, Raha Noorafshar, Sara Amini,
Volume 16, Issue 1 (1-2017)
Abstract
Background: The purpose of this study was to compare effects of three combined aerobic-resistance exercise training protocols with different intensities on metabolic control and Visfatin levels in men with type 2 diabetes.
Methods: 43 male patients with type 2 diabetes were randomly divided into 4 groups (three combined aerobic-resistance exercise training groups 1, 2, 3 and control). Training groups performed combined aerobic-resistance exercises for 12weeks, 3 times a week with given intensities )group 1:resistance 50-60% one repetition maximum- aerobic 70-80%maximum heart rate, group 2:resistance 60-70% one repetition maximum- aerobic 60-70% maximum heart rate and group 3:resistance 70-80% one repetition maximum- aerobic 50-60% maximum heart rate). Blood sampling to determine the levels of Visfatin, insulin, HbA1c, fasting glucose before and after 12weeks, were conducted.
Results: Visfatin levels and HbA1c in all training groups and fasting glucose in 2 combined training groups significantly decreased compared with control group (P<0.05). Vo2max was significantly increased in all training groups (P<0.05). No significant difference were observed between groups in body weight, Body mass index, fat mass, insulin levels and resistance insulin.
Conclusion: 12 weeks of combined aerobic-resistance exercise training protocols with were executed intensities through decreasing Visfatin and HbA1c levels and improving aerobic capacity could be helpful in patient with type 2diabetes. In addition to the above benefits, combined exercise training protocols of with intensity of 60-70% maximum heart rate–intensity 60-70% repetition maximum due to reducing fasting blood glucose could give greater benefits to patients.
Hadi Afshar Bakeshlou, Ahmad Abdi, Mohammad Ali Azarbayjani, Alireza Barari,
Volume 19, Issue 2 (1-2020)
Abstract
Background: Diabetes is a chronic and progressive metabolic disorder that leads to more severe cardiac complications. The aim of the present study was to investigate the effects of Berberine chloride at a dose of 50 mg / kg on the heart tissue of streptozotocin-induced diabetic rats with aerobic training.
Methods: 56 male Wistar rats were randomly divided into seven groups (n = 8): control (C), sham (S), Aerobic training control (TC), diabetes mellitus (DM), diabetes-berberine (BDM), diabetes mellitus. Aerobic training (TDM), and aerobic training-berberine (TBDM) were divided. Diabetes was induced by injection of streptozotocin in male rats. The training groups performed aerobic exercise program (10-18 m / min, 10-40 min five days a week) for six weeks on the treadmill for histological evaluation using hematoxylin and eosin (H&E), Masson trichrome and staining Immunohistochemicals were used to measure diameter change, cardiomyocyte rupture, change in nuclei, and collagen deposition in cardiac muscle fibers using one-way ANOVA and Tukey post hoc tests with SPSS 21 software.
Results: The results showed that DM group did not induce cardiomyocyte fibers rupture and collagen deposition and reduction of filament diameter in group C, S and TC and its damage in heart tissue was less in TBDM group than in BDM and TDM groups.
Conclusion: The results showed that berberine supplementation reduced these effects and synergized with aerobic training and reduced the cardiac cardiomyocyte muscle fibers diameter and decreased collagen deposition and better order of nuclei.
Negin Bozorgnejad, Hamid Reza Aghaei Meybodi, Mahdi Afshari, Negar Sarhangi, Mandana Hasanzad,
Volume 19, Issue 3 (2-2020)
Abstract
Background: Type 2 diabetes mellitus (T2DM) is the most common type of diabetes that was classically characterized by pancreatic β-cell dysfunction. Changes in circadian patterns is one of the reasons which can increase the occurrence of diabetes. Melatonin is one of the biological molecules which plays an important role in regulating the circadian clock and also an inhibitory effect on insulin secretion in β-cells. The aim of this study was to examine the association between MTNR1B (rs10830962) gene polymorphism and the risk of T2DM.
Methods: Genotyping was carried out in a total number of 208 subjects including 108 patients with T2DM and 100 normal controls using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) which is confirmed by Sanger sequencing method.
Results: The frequencies of CC, GC and GG among cases were 54.63%, 1.85% and 43.52% and in control subjects were 81%, 0% and 19% respectively (P<0.001). Frequency of G allele among diabetic patients was significantly higher than non-diabetics (OR=3.34, CI=2.10-5.36, P<0.001).
Conclusion: Our study showed that rs10830962 polymorphism of the MTNR1B gene can be directly associated with T2DM risk.
Afshar Jafari, Ali Zarghami Khameneh, Saeid Nikookheslat, Pooran Karimi,
Volume 19, Issue 4 (4-2020)
Abstract
Background: Autophagy is a new therapeutic strategy aimed at reducing the diabetic abnormalities. While excessive or insufficient autophagic activity during diabetes leads to altered cellular homeostasis. So, aim of the present study was conducted to determine the effect of eight-week high-intensity interval training (HIIT) along with caffeine injection on the levels of some myocardial autophagy-related proteins in diabetic rats.
Methods: In experimental design, fifty male white wistar rats with an age range of 3-2 months (average weight 250±25 g) were randomly divided into 5 groups of homogeneous 10 rats in each group: Healthy control (C: intraperitoneal injection of saline), Diabetic control (D: high-fat diet combined with a single intraperitoneal injection of streptozotocin, Diabetic with training (D+T: running with intensity at the 85-90% of maximum speed in 5 to 12 bout of 2 min-1; 5 days/week for 8 weeks), Diabetic with caffeine supplementation(D+CA: intraperitoneal injection of pure caffeine at 70 mg.kg-1 5 days/week for 8 weeks), Diabetic with training and with caffeine supplementation (D+T+CA). For evaluate changes in the expression profile of some of the genes associated with autophagy signaling pathway (LC3-II, ULK-1, Beclin1) in the myocardium (left ventricular), based on Western blot analysis will be used. Also, the one-way analysis of variance (ANOVA) and Tukey post hoc test were be used to analyze the data.
Results: The expression of all autophagic proteins in diabetic with trained and non-trained groups was higher than in healthy
group (P≤0.05). On the one hand, the expression of autophagy-related proteins in the trained group with caffeine supplementation was significantly higher than that of the training group without caffeine intake (P=0.001).
Conclusion: The findings of this study suggest that caffeine injection exacerbated the expression of autophagic proteins induced by diabetes; On the other hand, high-intensity interval training can as a preventive strategy, modulate diabetes-induced myocardial autophagy.
Anahita Fakhraei Nasab, Hamid Reza Aghaei Meybodi, Mahdi Afshari, Negar Sarhangi, Mandana Hasanzad,
Volume 19, Issue 4 (4-2020)
Abstract
Background: Type 2 diabetes Mellitus (T2DM) is a multifactorial, polygenic disease caused by impaired insulin secretion, insulin resistance and beta-cell dysfunction. Melatonin is a circadian rhythm regulator and any imbalance in its levels can be related to various metabolic disorders. Melatonin and the genetic variants of MTNR1B gene are reported to be associated with T2DM susceptibility. We investigated the association between rs4753426 variant in the MTNR1B gene and the risk of T2DM in group of Iranian patients.
Methods: In this case-control study108 T2DM and 100 normal individuals were recruited to genotyping by PCR- RFLP.
Results: It was observed a significant difference in CC, CT, and TT genotypes distribution between T2DM and control groups (P<0.001). Frequency of C allele among cases was significantly lower than controls (8.3% vs. 42.5% respectively, P<0.001) and C allele carriers had a 88% lower risk of developing T2DM than T carriers.
Conclusion: Our results showed that the rs4753426 variant of MTNR1B gene could reduce the risk of T2DM developing.
Ruqayyah Mansouri, Rasoul Shokri, Seyedeh Neda Mousavi, Davoud Afshar,
Volume 26, Issue 1 (4-2026)
Abstract
Background: The present study investigated the effects of curcumin supplementation along with a weight loss diet on the relative abundance of butyrate-producing bacteria in the gut of metabolically healthy obese men.
Methods: In the present double-blinded controlled clinical trial, sixty metabolically healthy obese men (body mass index ≥30 kg/m2) participated. Participants were randomly assigned to one of two groups receiving curcumin supplementation (500 mg, twice daily) or placebo. The duration of the intervention was eight weeks. The samples were matched for age and dietary intake before the study. Stool samples were collected at the beginning and end of the study and the relative abundance of bacteria was measured after DNA extraction.
Results: The relative abundance of Faecalibacterium prausnitzii in men undergoing placebo intervention decreased after 8 weeks (P= 0.04) and was significantly lower than that in the curcumin intervention group (P= 0.003). The mean changes in faecalibacterium prausnitzii increased in the curcumin while they decreased in the placebo group (P= 0.03). In addition, the mean changes in Roseburia intestinalis increased in the curcumin and decreased in the placebo group (P= 0.009).
Conclusion: Weight loss diet leads to a decrease in the relative abundance of butyrogenic bacteria in the gut of obese men, while curcumin supplementation can lead to an increase in the population of these bacteria, as one of the methods of treating obesity.
