Showing 3 results for Akhi
Zahra Kashi, Shiva Borzouei, Ozra Akhi, Narges Moslemi Zadeh, Hamidreza Zakeri, Reza Mohammadpour Tahmtan, Rafat Bonafti, Leila Shahbazadeh,
Volume 6, Issue 1 (19 2006)
Abstract
Background: Detecting mothers with gestational diabetes mellitus (GDM) is not only important in prevention of prenatal morbidities but also has significant effect on neonatal and maternal long term outcomes. Today, there are screening tests for GDM but they are time-consuming and expensive, therefore it seems necessary to perform testes that are uses expensive but with higher sensitivity and specificity. The aim of this study was to determine a cut - off point of fasting plasma glucose (FPG) for screening of GDM.
Methods: 200 pregnant women referring to the perinatal clinic of Imam Khomeini hospital, (Sari – Iran) were studied. All cases with age ≥25 years old, history of recurrent abortion, GDM, preeclampsia, macrosomia, still birth, diabetes mellitus(DM) in first degree family or pre gestational body mass index ≥25kg/m2 were selected. Those with pre gestational diabetes mellitus were excluded. All of participants underwent a 50 g glucose challenge test (GCT) between the 24th and 28th gestational week. If 1- hour plasma glucose was more than 130 mg/dl, a 3- hour 100g oral glucose tolerance test (OGTT) was performed. The diagnosis of GDM was made by ADA 2006 recommendation (Carpenter and Coustan diagnostic criteria). Referring to the Receiver Operative Characteristic Curve, level of FPG having highest sensitivity and specificity in diagnosis of GDM was determined.
Results: From 200 participants, 65 women had positive GCT, of them 58 (response rate 89%) referred for 100g OGTT and 20(10%) were diagnosed GDM. Using ROC curve and under curve area of 0.853 the FBG level of 91.5 mg/dl, showed the highest sensitivity and specificity, 80% and 92% respectively in diagnosis of GDM.
Conclusion: FBG ≥ 91.5 mg/dl has good sensitivity and specificity in screening of GDM. Since this is simpler and cheaper than 50g GCT, is recommended as a screening method in diagnosis of GDM.
Amirbahador Dakhili, Reza Gharakhanlou, Mansoureh Movaheddin, Ali Khazani, Mohammad Keshavarz,
Volume 13, Issue 3 (3-2014)
Abstract
Background: Diabetic neuropathy is one of the most common complications of diabetes
mellitus, which is associated with a decrease in the synthesis and transport of neurotrophins .
The aim of present study was to investigate the effect of endurance training on gene expression of
nerve growth factor (NGF) in the sensory spinal cord of rats with diabetic neuropathy.
Methods: Twenty eight adult male Wistar rats in the body mass range of 326.3±8.4 gr, randomly
assigned in to four groups: diabetic control, diabetic training, healthy control and healthy training. For
inducing diabetic neuropathy, after twelve hours of food deprivation, intraperitoneal injection of STZ
solution (45 mg/Kg) method was used. Two weeks after STZ injection, the endurance training
protocol was performed for six weeks and Twenty four hours after the last training session, rats were
sacrificed. Gene expression of NGF in rat spinal sensory segments were measured with Real time
technique. In order to determine the significant differences between groups and Interaction
independent variables two way anova and LSD post hoc test were used.
Results: Endurance training, resulted in a significant increase in gene expression of NGF in the rats.
Also, in compare with diabetic control, training led to significant decrease in blood glucose levels in
diabetic training group.
Conclusion: Increased physical activity and exercise can strongly affect pathological factors
associated with diabetic neuropathy by increasing nerve growth factor. It is recommended that for
prevention of neurological complications and treatment of diseases associated with diabets exercise
training could be used as a non-pharmachological treatment.
Mohammad Keshavarz, Reza Gharakhankou, Mansoureh Movaheddin, Leila Baghersad, Amir Dakhili, Ali Khazani,
Volume 13, Issue 4 (5-2014)
Abstract
Background: Increased and decreased CDK5 gene expression regulation, as a protein kinase, is associated with launching death or survival pathways in the nervous system. According to the chronic effects of endurance training on growth Germination, Neuronal function and improvement of pathological conditions of neurodegenerative diseases, the aim of our study was to investigate the effect of 6 Weeks Endurance Training on Gene Expression of Cdk5 in spinal motor part of Male Wistar Rats with Diabetic Neuropathy.
Methods: Twenty eight adult male Wistar rats ten year old in the weight range of 326.3±84gr, were randomly divided into four groups including healthy control (C), healthy training (HT), neuropathic control (N) and neuropathic training (NT). Diabetes was induced with one shut injection of STZ(45mg/Kg) and after confirmation of neuropathic condition with behavior tests, training groups performed 6 weeks endurance training(with moderate intensity and increasing) on the treadmill. CDK5 gene expression in Spinal motor segments forming the sciatic nerve was measured with Real time technique and calculated using the 2-ΔΔCT method.
Results: After 6 weeks of endurance training, CDK5 gene expression in spinal motor part of (NT) group was significantly lower than the (NC) group, also, in comparison with neuropathy control, training led to significant decrease in blood glucose levels in neuropathic training group.
Conclusion: According to the specific role of CDK5 in neuronal growth or death, our study showed the beneficial effects of Chronic endurance exercise on neural networks leading to reduced gene expression of CDK5 in a pathologic condition.
