Showing 5 results for Arshadi
Shahin Yarahmadi, Bagher Larijani, Ebrahim Javadi, Mohammad-Hassan Bastan Hagh, Mohammad Pajouhi, Reza Malekzadeh, Mahmood Mahmoudi, Aliereza Shafaei, Mohammad-Reza Mohajeri-Tehrani, Ali Rajabe, Mohammad Farshadi,
Volume 3, Issue 1 (16 2004)
Abstract
Celiac disease and typel diabetes mellirus have been linked to the same HLA markers and chromosomal loci, which may account for the concurrence of the two disorders in a significant number of patients. This study was designed to investigate the frequency of anti-gliadin antibodies, a marker for celiac disease, in diabetic patients.
Methods: In this study, 182 diabetic patients (52 with typel and 130 with type2 diabetes) were screened for anti-gliadin IgG by indirect immunofluorescence. Age range was 3-29.5 and 42-65 years for type 1 and type 2 diabetes groups.
Results: Anti-gliadin IgG was found in 1.9% and 1.5% of patients with type land type 2 diabetes. In Tehran, 0.02% of healthy blood donors have been reported to be seropositivitive for anti-gliadin IgG.
Conclusion: The prevalence of anti-gliadin seropositivity in type 1 and type 2 diabetics, was respectively 30 and 24 times higher than the general population of Tehran. This concurs with other reports indicating higher occurrence of celiac disease in diabetic populations. The rather low sensitivity and specificity (both around 80%) of the antigliadin antibody test has made it a suboptimal diagnostic test. However, it is quick and inexpensive and can be suitable for screening programs. We recommend the test in all at-risk populations including diabetics.
Farzad Hadaegh, Maryam Tohidi, Hadi Harati, Marjan Farshadi, Parisa Estaaneh,
Volume 4, Issue 1 (17 2004)
Abstract
Background: Diabetes type 1 is an autoimmune disease that is associated with other autoimmune disorders like Hashimoto thyroiditis. The purpose of this study was to determine the prevalence of autoimmune thyroid disease (ATD) in type 1 diabetic patients in the south of Iran (Bandar Abbas).
Methods: A cross-sectional study, was conducted 48 type 1 diabetics and 41 age and sex matched healthy controls were evaluated for the presence of ATD. Blood sample were collected from all of the subjects for the measurement of thyroid autoantobodies [anti thyroid peroxidase (anti-TPO) and anti thyroglobulin (anti-TG)], T3, T4, TSH, RT3U and HbA1c.
Results: Prevalence of positive anti-TPO and anti-TG was 29 % and 29% respectively in diabetic patients and 2% and 7% respectively in control group (P<0.05). The prevalence of ATD (positive anti TPO or anti TG) in diabetic patients and control subjects was 35% and 7% respectively (P<0.05). The prevalence of positive anti TPO and anti TG was higher in girls. There was no association between the prevalence of positive autoantibody and duration or age of onset of diabetes. 17.6% of diabetic patients with positive autoantibody had thyroid dysfunction (subclinical hypothyroidism and hyperthyroidism).
Conclusion: Regarding high prevalence of ATD in type 1 diabetic patients in Bandar Abbas (approximately 1 out of 3 patients), screening for ATD and thyroid dysfunction is recommended for all type 1 diabetic patiens and in those with positive autoantibody consecutively.
Marzieh Arshadi Mashkani, Mahsa Mohammad Amoli, Iman Salahshorifar, Farideh Razi,
Volume 16, Issue 3 (3-2017)
Abstract
Background: Diabetes is the most common endocrine disorder that affects many people every year. Diabetic nephropathy is main complication of diabetes type 2. Renoprotective effects of vitamin “D” in chronic kidney disease have been reported that including diabetic nephropathy. The purpose of this study is to investigate the association between polymorphism (rs731236 (Taq1)) at gene receptor vitamin D (VDR), and the risk of diabetic nephropathy in patients with type 2 diabetes.
Methods In this case-control study, 104 patients with type 2 diabetes and nephropathy, 100 patients with type 2 diabetes and no nephropathy, and 98 people without diabetes and nephropathy who referred to the Diabetes Clinic of Tehran University of Medical Sciences were included . Clinical data were obtained and biochemical parameters were measured. The DNA samples were extracted from blood samples by phenol chloroform method. TheTaqI polymorphism (rs731236) was studied by TaqMan specific genotypes.
Results: Urea, creatinine and urine albumin values were significantly higher and glomerular filtration rate was lower in nephropathy group. Although frequency of TT genotype and also T allele was higher in nephropathy group, the difference was not significant.
Conclusion: There was no association between Taq1 polymorphism and diabetic nephropathy in the studied population
Samira Majidi, Abdolali Banaeifar, Mohammad Ali Azarbayjani, Sajad Arshadi,
Volume 21, Issue 6 (3-2022)
Abstract
Background: Diabetes is the most common glandular disease in the world. The aim of this study was to compare the effect of three types of endurance, resistance and combination training on inflammation and insulin resistance in visceral adipose tissue of type 2 diabetic rats.
Methods: For this purpose, among eight-week-old male Wistar rats, 48 rats were selected and randomly divided into 6 groups (diabetic endurance training, diabetic resistance training, diabetic combination training, healthy combined training, healthy control and diabetic control). The rats became diabetic by injecting 95 mg of nicotinamide and after 15 minutes of STZ injection at the rate of 55 mg/kg body weight. 4 days after injection, rats with serum glucose above 300 mg/dL were considered diabetic. Then, the endurance training group trained for 6 weeks, 3 sessions per week with moderate intensity (50-60% of maximum oxygen consumption). The initial load to start resistance training was 50% of the rat's body weight. Each session added 15% of body weight to the weights. The combined exercise group also performed resistance and endurance exercises in a row. 48 hours after the last session, the rats were anesthetized and visceral adipose tissue was removed to examine the variables.
Results: The results showed that there was a significant difference between the effect of six weeks of endurance, resistance and combined exercise on inflammation and insulin resistance in the visceral adipose tissue of male diabetic mice.
Conclusion: The results confirm the effect of three training methods on the mechanisms involved in diabetes.
Fahimeh Kalhor, Sajad Arshadi, Ardeshir Zafari, Abdolali Banaeifar,
Volume 22, Issue 1 (4-2022)
Abstract
Background: Obesity has been recognized as one of the top 10 health problems by the World Health Organization. The purpose of the present study was to the effect of aerobic training on atrogin, eotaxin and IL-10 indices in obese women.
Method: The present applied research was a quasi-experimental study in which 30 obese women aged 30-45 years were selected by available method from South Tehran Azad University (2016-2017) and randomly divided into two groups of aerobic exercise and control. 24 hours before the start of training, the individual characteristics of the subjects and the research variables (atrogen, eutoxin and IL-10) were measured in blood tissue, then the subjects of the experimental group had their training program for 8 weeks, 3 They performed one session per week and each session lasted 45-60 minutes under the supervision of a researcher. Dependent and independent t-test was used to analyze the data.
Results: Due to the lack of differences in pre-test scores, it was found that the groups were identical. It was also found that 8 weeks of aerobic exercise had a significant effect on the levels of eutoxin, atrogen and interleukin-10 in obese women (p = 0.001)
Conclusion: According to the research results, it is recommended that obese women exercise aerobically. Use to reduce the negative effects of obesity.
