Iranian Journal of

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Background: BDNF decrease, and HbA1c and Asprosin increase in diabetic people and exercise can reverse these effects, but the effect of vigorous exercise on Asprosin and BDNF in elderly diabetic people have not been investigated. Therefore, the aim of the present study was to investigate the effect of high-intensity functional exercise on Asprosin and BDNF and their relationship with glucose and HbA1c in elderly diabetic men and women.
Methods: In this semi-experimental study, 24 elderly diabetic men and women (age: 67.25 ± 5.84, BM: 70.29 ± 13.01, height: 160.92 ± 10.29) participated. The initial blood sample was taken while fasting. After 90 minutes, the subjects performed the exercise for 50 minutes. The second blood sample was taken 10 minutes after the high-intensity functional exercise. BDNF, Asprosin, HbA1c, and glucose levels were measured by ELISA method. To analyze the data, T-tests, covariance and Pearson's correlation coefficient were used.
Results: Asprosin and BDNF decreased (P< 0.0005) and increased (P< 0.0005), respectively in both groups. There was no significant difference between Asprosin and BDNF in elderly diabetic men and women in pre-test and post-test (P> 0.05). There was a significant negative correlation between BDNF with Asprosin, HbA1c and glucose and a significant positive correlation between Asprosin with HbA1c and glucose (P< 0.05).
Conclusion: Vigorous exercise decrease and increase Asprosin and BDNF in elderly diabetic men and women, respectively. Also, considering the significant negative relationship between BDNF with glucose and HbA1c and the significant positive relationship between Asprosin with glucose and HbA1c, it seems that vigorous exercise by reversing the changes of asprosin and BDNF causes possible improvement in levels of glucose and HbA1c.

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Background: National Document for the Prevention and Control of Non-Communicable Diseases (NCDs) and Related Risk Factors, developed in 2015, serves as Iran’s roadmap for guiding health policies to manage NCDs. After a decade, assessing its implementation and progress is essential. We aimed to review and synthesize existing evidence on the implementation status of the document’s interventions, and identify facilitators, barriers, and strategies to enhance its execution.
Methods: Following the PRISMA-ScR 2020 checklist, a systematic search was conducted in PubMed, Scopus, Web of Science, SID databases, Google Scholar, organizational repositories, and reference lists of related studies in Persian and English. Research or review studies that evaluated at least one objective or intervention of the national document—using health or health system indicators in Iran—were included. Three researchers independently performed screening and data extraction. Data were analyzed narratively and organized into thematic categories.
Results: Overall, 78 studies, reports, and national documents were included. Implemented actions encompassed establishing committees, developing action plans, integrating services into the health system, revising standards, producing educational materials, launching registries, and signing multisectoral cooperation agreements. Facilitators included legal support, intersectoral collaboration capacities, service delivery structures, and community capabilities. Major challenges were deficiencies in the national document, limited resources, weak coordination, and external disruptions such as COVID-19 and sanctions. Recommended strategies emphasized strengthening cost-effective interventions, continuous monitoring, securing sustainable resources, improving service delivery models, and enhancing multi-sectoral approaches.
Conclusion: Successful implementation of NCD prevention and control policies requires evidence-informed policymaking, prioritization of cost-effective interventions, ongoing evaluation, and sustained managerial support.