Roya Askari, Amir Hosein Haghighi, Neda Badri,
Volume 17, Issue 4 (5-2018)
Abstract
Background: Increasing blood glucose levels is associated with a reduction in the antioxidant defense of the body. The purpose of this study was to compare the effect of aerobic resistance exercises with and without ginger on some of the oxidative and antioxidant indices in type 2 diabetic women.
Methods: Twenty-two type 2 diabetic women with a mean age of 49.47±4.36 years, BMI 31.3±16.3 kg / m2, height 0.56±0.04 meters were selected randomly and they were divided into two experimental and control groups. Both groups performed 12 weeks, 3 sessions per week, exercises with intensity of 75-85%, 1RM in 8 stations, and after 5 minutes of rest, aerobic training exercises with an intensity of 75-85% of MHR. A daily group of 800 mg capsules of ginger rhizome powder and the other group consumed capsules containing wheat flour. 24 hours before and after training, MDA, TAC, SOD, GSH, HbAlc, glucose and insulin and body composition were measured.
Results: 12 weeks of combination exercise caused a significant decrease in glycosylated hemoglobin, insulin resistance, insulin resistance, lipid percentage, and a significant increase in TAC and GSH compared to baseline (P <0.05), while SOD and MDA Did not have any significant effect.
Conclusion: Combined exercise with and without zinc seems to improve antioxidant and some of the body composition indices in type 2 diabetic women.
Zahra Badri, Maryam Delfan, Saeid Danesh Yar,
Volume 22, Issue 4 (11-2022)
Abstract
Background: Myogenin (MyoG) and Myostatin (Mstn) play role in muscle growth and wasting, respectively. The present study aimed to investigate the combined effect of High-intensity Interval Training (HIIT) and Metformin drug (Metf) on gene expression of MyoG and Mstn in skeletal muscle of type 2 diabetic mice.
Methods: 25 mice (C57BL/6) were assigned to two groups, including 1) Control © (n=5), and 2) HFD (n=20). The mice of the HFD group were fed a high-fat diet for 16 weeks. After 16 weeks, the mice with over 200 mg/dl were selected as diabetic mice. Then, the diabetic mice were divided into four groups including 1) Control Diabetic (CD) (n=5), 2) Diabet with Metf (DM) (n=5), 3) Diabet with HIIT (DH) (n=5) 4) Diabet with Metf and HIIT (DMH) (n=5). The mice of experimental groups underwent the interventions for eight weeks. The Real-Time–PCR methods were used to measure the mRNA expression of MyoG and Mstn in the Rectus-Femoris muscle.
Results: HIIT (but no Metf) upregulated the gene expression of MyoG (p=0.05). Metformin did not affect Mstn expression (p=0.45), However, HIIT downregulated the expression of Mstn (p=0.001). Metformin did not affect decreasingly or incrementally the downregulating effect of HIIT on Mstn expression (p=0.95).
Conclusion: Metf may not positively or negatively affect the expression changes of MyoG and Mstn induced by HIIT in skeletal muscle of mice with type 2 diabetes.
