Showing 8 results for Bahrami
Amir Bahrami,
Volume 3, Issue 2 (16 2004)
Abstract
Background: Polycystic ovary syndrome (PCOS) which is characterized by menstrual irregularities (due to chronic anovulation) and hyperandrogenism is one of the most common endocrine disorders of women at reproductive age. The precise cause of PCOS is unknown, but it seems that several factors may have role in its pathogenesis. Insulin resistance and impaired insulin secretion are common findings in PCOS patients. Approximately 30 – 40 % of women with PCOS have impaired glucose tolerance or type 2 DM. According to my knowledge, there is no published study about prevalence of IGT and type 2 Diabetes Mellitus (type 2 DM) in Iranian women with PCOS. The aim of this prospective, controlled study was to determine the prevalence of abnormal glucose metabolism in women from north west part of the country.
Methods: 302 PCOS women and 116 normal women as a control group were prospectively studied. The diagnosis of PCOS was made based upon the presence of chronic anovulation and hyperandrogenemia. Other causes of hyperandrogenism were excluded by appropriate clinical and laboratory evaluations. None of the patients were known diabetics prior to study. In all patients with PCOS and control women appropriate medical history was taken and physical examination was done. Blood pressure, body weight, height, BMI, waist / hip ratio, score of hirsutism and other signs of androgen excess were determined. Serum concentrations of total testosterone and DHEA–S were measured by RIA methods in both patients and control group. Standard Oral Glucose Tolerance Test (OGTT) with 75 grams oral glucose was performed between 8 -9 AM after an overnight fast of 10 – 12 hours. Fasting and 2 – hour post - glucose plasma sugars were measured by glucose oxidase method. Results: Results of OGTT were interpreted according to WHO criteria. Mean age and mean BMI were similar in both patients and controls. Serum levels of total testosterone and DHEA – S were significantly higher in PCOS women in comparison with controls. 65% of patients and 68% of controls had BMI of ≥ 25 kg / m2. 55% of PCOS women and 51.6% of control women were obese (BMI ≥ 27kg/m2). 96 (31.7%) of PCOS women had impaired glucose tolerance (IGT) and 27 (8.9%) were diabetics. The prevalence of IGT and diabetes in controls were 14.6% and 5.1% respectively. In non-obese PCOS women the prevalence of IGT and DM were 17.2% and 3.6% respectively, while only 8.9% of control women had IGT and 1.7% were diabetics. Finally, 44.1% of obese PCOS women were glucose intolerant and 13.5% had diabetes mellitus in comparison with 20% and 10% of controls. Conclusion: It is concluded that the prevalence of IGT and DM in both obese and non–obese PCOS women were significantly higher than in control women. Screening of all PCOS women for IGT and DM is highly recommended.
Nosratollah Zarghami, Amir Bahrami, Majid Mobasseri, Bagher Larijani, Pooran Karimi, Behrang Alanii,
Volume 5, Issue 3 (17 2006)
Abstract
Background: Diabetes is a common endocrine disease in human kind. In most type II diabetic patients, obesity and overweight status account as the serious health problems worldwide and variety of endocrine factors well known that have regulatory role in weight balance and body composition including Leptin and IGF-I factor. The aim of this study was to examine the correlation between Leptin and IGF-I in type II diabetics and controls.
Methods: As a case- control study, 38 type 2 diabetics (20 males and 18 female with mean age 49.22) and 46 healthy controls (16 males and 30 females with mean age 49.52) are recruited. We measured the concentrations of FPG, IGF-I, HbA1C and IGFBP-3 in both groups. FPG was measured by enzymatic glucose oxidase method and Hb Gold analyzer HPLC was used to measure HbA1C. Determination of Leptin, IGF-I, IGFBP-3 and Insulin concentrations were carried out using ELIZA method. P< 0.05 was considered as statistically significant.
Results: The mean of BMI and age were not significantly different in both groups. The mean serum levels of IGF-I, Leptin, Insulin, FPG and HbA1c concentrations in type II diabetics were significantly higher than controls (P< 0.05). In males, the mean serum levels of Leptin were statistically lower than in females in both groups. There was a strong correlation between IGF-I and IGFBP-3, Leptin and insulin, IGF-I and age, and BMI with FPG in both patients and controls (P< 0.05). A reverse correlation was observed between IGF-I and HbA1c in patients and controls (P< 0.05).
Conclusion: It is speculated that based on this findings, Leptin and IGF-I system could have regulatory roles in body composition and fat content particularly in obese and overweight diabetic patients and have significant correlation with Insulin, glucose, BMI and age.
Amir Bahrami, Nosratollah Zarghami, Liela Khajehali,
Volume 6, Issue 3 (17 2007)
Abstract
Background: Type 2 diabetes mellitus is a common metabolic disorder witht increasing prevalence is increasing worldwide. C-Reactive Protein (CRP) is a marker of systemic inflammation and an independent risk factor for cardiovascular disease (CVD). The aim of this study was to elucidate the correlation between glycemic control and systemic inflammation by measuring serum CRP levels.
Methods: In this cross sectional study 136 patients with type 2 diabetes mellitus (69 females, 67 males) were recruited. In addition to measurement of CRP levels by highly sensitive methods and measurement of hemoglobin A1C effects of influencing factors on the CRP level was considered. Fasting plasma glucose was determined via the glucose oxidase method, HbA1C via HPLC, serum lipid profile enzymatically and hs-CRP with sandwich immunoassay method.
Results: The mean concentrations of CRP levels in these patients (5.2 ± 4.8 mg/L) were higher than normal range and in women greater than men (6.4 ± 5.5 vs. 3.9 ± 3.6 mg/L). Before adjusting for influencing factors the association between hs-CRP levels and hemoglobin A1C was negative but not statistically significant (r= -0.15, P=0.07). After adjusting, the association was negative and significant. (r= -0.22, P= 0.02). In this study the relation between hs-CRP and lipid profile was also determined. There was no significant relationship between the levels of hs-CRP and total cholesterol, LDL-C and HDL-C. A positive correlation between hs-CRP with serum triglyceride and triglyceride / HDL ratio was observed. However, the correlation was not significant.
Conclusion: These results demonstrate that hs-CRP levels is influenced with multiple factors, and increased hs-CRP levels in patients with type 2 diabetes mellitus can not be explained with hyperglycemia alone.
Ghorban Mohammadzadeh, Nosratollah Zarghami, Amir Bahrami, Baghar Larijani,
Volume 7, Issue 2 (17 2007)
Abstract
Background: Adiponectin is an adipose tissue-derived hormone that low levels of this hormone are associated with obesity, insulin resistance, and type 2 diabetes. The aim of this study was to compare the serum levels of adiponectin in diabetic and non-diabetic obese individuals.
Methods: As a cross-sectional study 35 obese individuals with type 2 diabetes mellitus and 35 non-diabetic obese subjects were enrolled. Two groups were matched for age, gender and body mass index. Fasting lipid profile was measured via the enzymatic methods. The NycoCard HbA1c Kit was used to measure HbA1c.The Serum Adiponectin, insulin and glucose levels were measured via an enzyme immunoassay, using a commercially available kit and glucose oxidase methods, respectively. The HOMA and QUICKI indices were used to determine insulin resistance and insulin sensitivity, respectively.
Results: The mean of insulin resistance index (HOMA-IR), HbA1c, diastolic blood pressure, triglyceride and fasting glucose in diabetes were significantly higher than non-diabetics (P<0.05). The serum Adiponectin levels was significantly lower in diabetes than non-diabetics (15.74±6.70 vs. 21.52 ± 9.35) and was significantly higher in women than men (19.38 ± 7.33 vs. 12.68 ± 4.28) among diabetic and (24.63 ± 10.52 vs. 17.83 ± 6.21) among non-diabetics groups.
Conclusion: type 2 diabetes mellitus is associated with low serum adiponectin concentrations and probably adiponectin involved in the pathophysiology linking obesity to type 2 diabetes.
Melika Beihaghi, Hamideh Ghodrati Azadi, Zhila Taherzadeh, Hamid Reza Bahrami,
Volume 16, Issue 3 (3-2017)
Abstract
Background: In recent years, dietary supplements play an important role in maintaining a healthy diet in most chronic diseases such as diabetes. Spirulina platensis as a food supplement has been raised and regulator effects on cholesterol and antioxidant and immune regulating effects of this supplement are also considered. It contains vitamin B, beta-carotene, vitamin E, high value proteins, minerals, gamma linolenic acid and antioxidants.
Methods: In this study 50 patients with type II diabetes were randomly selected and after taking patient's history they were divided into two equal groups including control. 8 grams of spirulina that was prepared in tablet (each 1 gram) form was administered daily to patient group for three months. Fasting blood sugar levels monthly and hemoglobin A1C levels at the beginning and end of the projects were measured in both groups and their results were compared with each other.
Results: Fasting plasma glucose in patient group after 3 months of treatment with spirulina powder gave a significant reduction from the 158.1± 44.2 mg/dl at the beginning of study to 127.8 ± 36.7 mg/dl but was not significant in the control group. Glycosylated hemoglobin in the both groups decreased but this decrease was not statistically significant.
Conclusion: Spirulina platensis as a supplement can be administered in type II diabetic patients that used oral anti-diabetic drugs. It is effective in reducing fasting blood glucose in the short term but its effect on hemoglobin A1C need to prescribe longer.
Fatemeh Nikseresht, Mostafa Bahrami, Masoud Rahmati,
Volume 21, Issue 5 (1-2022)
Abstract
Background: The objective of this experimental study was to determine the effect of 6 weeks of high intensity interval training (HIIT) on G6Pase expression in liver tissue, serum insulin and glucose and insulin resistance in obese rats with type 2 diabetic and compared with non-diabetic obese group.
Methods: 28 male Wistar rats aged 10 weeks (220 ± 10 g) were obesed by 6 weeks of high-fat diet (HFD). Then type 2 diabetes induced in 14 rats by intraperitoneal injection of STZ (30 mg/kg). Finally, the studied rats were divided into 4 same groups: 1) control obese, 2) interval obese, 3) control diabetic, 4) interval diabetic. Interval groups participated in an interval exercise program of 5 sessions per week for 6 weeks consists of 10 repetitions of a 40-second run on the treadmill with 2-minute rest (active rest) between repetitions. 48 hours after the lasting session, fasting levels of glucose, serum insulin and G6Pase expression in liver tissue in all 4 groups were measured and compared with 2 way ANOVA.
Results: Compared with diabetic control groups, HIIT in diabetic group resulted in significant decrease fasting glucose (p= 0.001). HIIT also led to an increase in serum insulin (p= 0.006) without change in G6Pase expression (p= 0.102) compared to the diabetic control group.
Conclusion: Improved glucose response to interval training in type 2 diabetic rats may be rooted in increase insulin without changes in hepatic G6Pase expression. Measurement of activity or expression of other liver enzymes is suggested for general conclusion.
Soroor Kazemi, Sheida Sodagar, Sadegh Taghiloo, Maryam Bahrami Hidji, Nooshin Shirzad,
Volume 22, Issue 5 (12-2022)
Abstract
Background: The present study was conducted with the aim of comparing lifestyle education based on the Bezenf model and the World Health Organization model on FBS, 2HPPBS, HbA1c in patients with type II diabetes.
Methods: The research method was a semi-experimental and multi-group expanded type with pre-test-post-test designs and a control group with a follow-up period. The statistical population of this research included all patients with type II diabetes referred to the endocrinology department of Imam-Khomeini Hospital in 1400. In this research, from a list of 100 people with diabetes, 60 diabetic patients who met the entry criteria were identified. Then 45 people were randomly selected and replaced by random replacement in two experimental groups and one control group. Each experimental group received group psychological interventions separately, and at the end, both groups were subjected to a post-test. The obtained data were analyzed using mixed analysis with repeated measurements.
Results: The results indicate the effect of lifestyle education based on the Bezenf model and the World Health Organization model on FBS (P=0/001), 2HPPBS (P=0/001) and HbA1c (P=0/006) and the stability of this effect was in the follow-up phase. Also, compared to lifestyle education based on the World Health Organization model, lifestyle education based on the Bezenf model was a more effective method to reduce HbA1c in type 2 diabetes patients but the difference in the effect of the two groups on FBS and 2HPPBS was not significant.
Conclusion: The results indicated the effectiveness of both educational models and the superiority of the BAZENF educational model. Therefore, Lifestyle education based on the Bezenf model and the World Health Organization model can be used by therapists as adjunctive treatments in interventions for people with type 2 diabetes.
Asma Soleimani, Mohammad Fathi, Mostafa Bahrami,
Volume 24, Issue 3 (7-2024)
Abstract
Background: The purpose of this study was to investigate the effect of sports rehabilitation exercises with vitamin D consumption on fatigue, sleep quality and depression level of people with osteosarcoma cancer after bone marrow stem cell transplantation.
Methods: In this study, 27 women with osteosarcoma cancer with body mass index above 30 kg/m2, age 24.90±4.03 years, height 163.85±3.62 cm and weight 82.17±4.5 kg were randomly divided into four groups. (patient-exercise), (patient-exercise-vitamin D), (patient-exercise-placebo) and (control) were divided. The training protocol includes ten weeks of Pilates exercise. The supplement group took 500 IU of vitamin D three days a week for 10 weeks. Data were analyzed using dependent t-test and one-way analysis of variance.
Results: The results of the covariance analysis of the research of three exercise groups showed that after ten weeks of sports rehabilitation with vitamin D consumption, the indicators of fatigue and the level of depression decreased significantly (P≤ 0.05). Also, the results of covariance analysis of the three training groups showed that the overall sleep quality of people with osteosarcoma cancer increased significantly (P≤ 0.05). Conclusion: Based on the obtained results, it is suggested that the consumption of vitamin D along with exercise rehabilitation can be an effective treatment method for fatigue, sleep quality and depression in people with osteosarcoma cancer.
Conclusion: Based on the obtained results, it is suggested that the consumption of vitamin D along with sports rehabilitation can be an effective treatment method for fatigue, sleep quality and depression in people with osteosarcoma cancer.
