Showing 2 results for Derakhshan
Mohammad Jafar Mahmoudi, Soodabeh Alataab, Farshad Sharifi, Farhang Derakhshan, Hossein Fakhrzadeh,
Volume 13, Issue 6 (9-2014)
Abstract
Background: Metabolic syndrome is a cluster of disorders which altogether increase the risk of cardiovascular disease and type 2 Diabetes. We evaluated the effect of consumption of Omega-3 Fatty Acids on different components of this syndrome.
Methods: This was a double blind placebo controlled clinical trial on 199 elderly residents of Kahrizak charity foundation in Tehran. Participants were divided into two groups of intervention and control, consisting of 100 and 99 persons, respectively. The intervention group was given the Omega-3 Fatty Acid capsules contain 180 mg EPA and 120 mg DHA once daily. The control group was given placebo once per day. The duration of the study was 6 months in the beginning and after 6 months of the study, blood pressure, waist circumference and Serum levels of ESR, hs-CRP, APO B, APO A1 and Insulin were measured.
Results: The study was completed in 89 and 87 participants in the intervention and control groups, respectively. The mean age of intervention and control groups were 74.13 ± 9.96 and 75.17 ± 8.70 years, respectively. Consumption of Omega-3 Fatty Acids could decrease diastolic blood pressure (P = 0.001) and serum Triglyceride levels (P = 0.01) significantly compared to control group. No change was observed in other measured parameters.
Conclusion: Consumption of Omega-3 Fatty Acids with dosage used in this study could probably improve symptoms of Metabolic syndrome in the elderly.
Mohamad Derakhshandeh, Farzaneh Taghian, Khosro Jalali Dehkordi, Ali Hoseini,
Volume 21, Issue 6 (3-2022)
Abstract
Background: Artificial intelligence analysis based on the gene list obtained from the DisGeNET database identified the important genes involved in the heart damage process. Data enrichment highlighted the apoptosis signaling pathway as a vital pathway in cardiovascular risk. Hence, we estimated the binding affinity of chemical and plant bioactive molecules for cytochrome-c protein. Here, we performed to evaluate the effect of eight weeks of resistance training (RT) with Tribulus Terrestris (TT) consumption on the mechanism of apoptosis in the heart tissue of rats exposed to stanozolol.
Methods: Thirty-five male rats were divided into seven groups: (1) Control, (2) Stanozolol (ST), (3) ST + 100 mg / kg TT, (4) ST + 50 mg / kg TT, (5) ST + RT (SRT), (6) S + RT + 100 mg / kg T (SRTT100), and (7) ST + RT + 50 mg / kg T (SRTT50). Differential gene expression was measured by q-RT-PCR. In bioinformatics analysis, the apoptosis signaling pathway was defined as a critical process in heart damage. In addition, adverse effects of Tribulus Terrestris and stanozolol on heart tissue were detected through the apoptotic pathway by molecular docking.
Result: Resistance training along with 100 mg/kg reduced CRP and cytochrome-c Moreover, 100 mg/kg TT as a more favorable effect than 50 mg/kg TT
Conclusion: we showed the beneficial effects of Tribulus Terrestris, the plant’s bioactive compound that can reduce cardiovascular risks by impairing the formation of apoptosome assemblages and inflammation.
