Showing 10 results for Ebrahimi
Ghasem Sazegar, Vahid Ebrahimi, Mohammad Javad Saeedi Boroujeni, Shabnam Mohammadi, Ramin Salimnezhad,
Volume 14, Issue 1 (1-2015)
Abstract
Background: Given diabetes mellitus has an adverse effect on spermatogenesis and male fertility, the aim of the present study was to investigate the effect of L-carnitine administration on spermatogenesis and testicular structure in diabetic rats induced with Stereptozotocin.
Methods: In this experimental study, fifteen rats were randomly divided into 3 groups: control group was received citrate buffer. Case group was diabetic rats that received 40 mg/kg carnitine for 16 days. Third group was diabetic rats that did not receive carnitine. After sixteen days, morphometric study was performed. Besides, index of testicular weight was obtained. Then, data were analyzed using SPSS software and ANOVA.
Results: In testicular sections of diabetic rats were observed a disruption and deformity in first layer of somniferous tubules. Statistical analysis showed a significant difference in carnitine group when compared to the control group (P<0.05). There was a significant difference between weight of diabetic rat compared to the control group (P<0.001). Besides, there was the most ratio of testis index in control group.
Conclusion: Our finding showed that short-term L-carnitine administration was affective on the diameter and thickness of seminiferous tubules. Hence, L-carnitine treatment may cause an improvement in spermatogenesis of diabetic men.
Farid Bahrpeyma, Mehdi Ebrahimi, Razieh Javadian Kotenaei,
Volume 15, Issue 2 (1-2016)
Abstract
Background: One of the most common complications of Diabetic Polyneuropathy (DPN) is decreased balance and Postural Control disorder. Balance has an important role in static and dynamic activities as a base of activities of daily living. The objective of this study was the evaluation and comparison of dynamic and functional balance in patients with DPN and healthy subjects.
Methods: In this study, dynamic and functional balance of 11diabetic patients with DPN (detected by Michigan questionnaire) and 11 healthy subjects were evaluated by Biodex Balance System (BBS) and Tandem Stance (TS) test in open and closed eyes conditions. The participants were matched by age and BMI. An independent t-test was used to compare balance parameters between patient and normal group. Furthermore, the correlation between dynamic balance parameters of BBS and TS tests were calculated using the Pearson’s Correlation Coefficient.
Results: The results of BBS in patients with diabetic peripheral neuropathy were significantly higher than normal subjects (P<0.05). The mean of time of TS test in diabetic group was significantly lower than healthy subjects (P<0.05). Also there was a significant (P=0.004) negative (r = 0.794) correlation between Medio-Lateral stability index (recorded from BBS) and TS with open eye, in diabetes group.
Conclusion: Older adults with DPN have an impaired functional balance in comparison with matched control subjects and this may expose the patients to danger of falling during daily activities.
Mohammad Hossein Hajiebrahimi, Atieh Qanehari, Abdurrahman Charkazi, Zahra Hajiebrahimi,
Volume 16, Issue 4 (9-2017)
Abstract
Background: Increasing number of elder people accompanied with an increasing number of subjects with chronic diseases among them. The aim of this study was to compare the results of physical condition of elder people in Grogan city, Golestan, Iran, in 2009 with the results in 2004.
Methods: Through a cross-sectional study using a standard questionnaire data on 884 elder people who were resident in 4th and 5th health station covered by Gorgan health center at 2009 were collected by trained persons as self-report. Participants entered in the study through a census method are asked about their physical condition. Using Qui-Square method, collected data has been analyzed. The results were compared with the outcomes of pervious study (unpublished) at 2004 which has been carried out among 315 elder people in the same study area. SAS 9.2 software has been used for data analyzing.
Results: Mean age of elders at 2009 was 67.20±6.67 years and at 2004 was 67.59±6.72 years. Frequency of Hypertension, hyperlipidemia, asthma, diabetes showed a statistically significant (p<0.05) increase in 2009 compared with 2004. On the other hand, the frequency of epilepsy, losing of teeth, inguinal hernia and heart burn decreased during these years, statistically significant again (p<0.05).
Conclusion: The results of the current study indicated that cardiovascular disease significantly increased in second phase of the study rather than first one. It is necessity to interventions to the control of these problems.
Baharak Najafi, Parisa Taheri Tanjani, Farshad Sharifi, Hosein Fakhrzad, Mahtab Alizadeh, Masoud Arzaghi, Mehdi Varmaghani, Mahdi Ebrahimi,
Volume 16, Issue 5 (10-2017)
Abstract
Background: The aging of the population is a great challenge of the public health in this century. The health promotion of the elderly people requires a comprehensive and accurate understanding of their health status.
Methods: This cross-sectional study has assessed the health status of 191 old people ≥ 60 in Sistan and Balouchestan province that selected by a multi-level cluster random sampling. General health data was collected using SF-36 questionnaire, nutrition status was assessed using Mini Nutritional Assessment (MNA), depression status was detected by the geriatric depression scale-15 (GDS-15), functional status was assessed using the activity daily living (ADL) and instrumental activity daily living (IADL) questionnaires, as well as, the information about demographic, history of diseases, vaccination, participation in social activities, and the utilization of elderly care services were evaluated by an approved questionnaire. History of hypertension was asked from the participants. Moreover the blood pressures of them were twice measured.
Results: The mean age of the participants was 69.81 (8.32) years. The health status was reported excellent and bad by 4.2% and 9.4% of the participants, respectively. The prevalence of fall in recent year, memory disorder, hearing and visual impairment, and malnutrition were 35.3%, 15.6%, 30.3%, 56.6%, and 8.9%, respectively. The prevalence of dependency in "activity of daily living" and "instrumental activity of daily living" were 25.8% and 58.2%, respectively.
Conclusion: It seems that the prevalence of malnutrition, impaired ADL and IADL, and memory impairment in the older population of Sistan and Baluchestan are above the national and global averages.
Parisa Taheri Tanjani, Mehdi Varmaghani, Neds Nazari, Farshad Sharifi, Hossein Fakhrzadeh, Seyed Masoud Arzaghi, Mahtab Alizadeh Khoee, Mohammad Smaeel Motlagh, Mahdi Ebrahimi,
Volume 16, Issue 5 (10-2017)
Abstract
Background: Elderly people need more receiving health services. Planning to provide services at regional and national levels requires information about the health status of the elderly. This study was performed to assess the health status of East Azarbaijan province.
Methods: In this cross-sectional study, 436 subjects were enrolled (180 men and 258 women) aged ≥ 60 years using multi-level proportioned cluster Random sampling from 19 cities of the province.
Data was collected by a demographic questionnaire , measuring anthropometric characteristics, and blood pressure and using "Mini Nutritional Assessment" ,”Geriatric Depression Scale-15 ", “Katz’s Activity of daily living”, and "Lawton’s Instrumental activities of daily living”.
Results: The mean age of the participants was 69.31 years. The self-reported prevalence of diabetes was 34.2%. The prevalence of hypertension in the elderly was 52.5%. The most common complaint of the participants was pain (60.9%). Totally, 46.9% had a difficulty in walking, 44.3% visually impaired, and 26.4% suffered from hearing impairment. Moreover, 44.8% of sleep disorders was found. Also 26% of the participants had depressed mood.
Conclusion: Elderly residents of East Azerbaijan province, has probably a better health status than the average Iranian elderly. However, there is a high prevalence of hypertension and diabetes among older adults of this province that need to more pay attention.
Parisa Taheri-Tanjani, Farshad Sharifi, Neda Nazari, Hossein Fakhrzadeh, Mahtab Alizadeh-Khoee, Mohammad Smaeel Motlagh, Hosna Ataee, Seyed Masoud Arzaghi , Mahdi Ebrahimi,
Volume 16, Issue 5 (10-2017)
Abstract
Background: Alborz Province is one of the provinces that accepted immigrants. Immigration has a profound effect on physical and mental health in elderly. This study was performed to assess the health status of Alborz province older population.
Methods: In this cross-sectional study, 235 subjects were enrolled (113 men and 122 women) aged ≥ 60 years using multi-level proportionated cluster random sampling that selected from 19 cities of this province. Data was collected by a demographic questionnaire, measuring anthropometric characteristics, and blood pressure and using "Mini Nutritional Assessment", ”Geriatric Depression Scale-15 ", “Katz’s Activity of daily living”, and "Lawton’s Instrumental activities of daily living”. Data was analyzed with spss21.
Results: The mean age of the participants was 68(6.00) years. The prevalence of anxiety and depression among the participants was as 51.5% and 34%, respectively. At risk or malnutrition was observed in 27% of the participants and 54.5% had suffered dental problems and 49.8% also had problem in walking.
Conclusion: Overall, the health status of elderly people in the Alborz, perhaps slightly better than the national average, but the high prevalence of metabolic disorders also the high prevalence of depression and anxiety require serious intervention by policy makers to promote the health in elderly.
Elham Ebrahimi, Bahman Sadegi Sedeh, Mohammad Reza Rezvanfar,
Volume 17, Issue 3 (3-2018)
Abstract
Background: Insulin is first choice for gestational diabetes control, but its needed to frequent injections; one thing that is difficult for pregnant women, so interest to metformin consumption is increased. Metformin easily crosses the placenta and its fetal blood levels is equivalent to the level of the mother's blood. Metformin also easily cross the brain barrier and enter the brain. Possible side effects of metformin compared to insulin on fetus brain development was concerned to design of present study.
Methods: In this cross-sectional prospective trial, gestational diabetes women were recruited randomly to insulin (64 patients) and metformin (64 patients) groups and compared for pregnancy and neonatal outcome and also six-month-old infancy developmental indexes. The results considered significant if P value was ≤ 0.05.
Results: Six-month body mass index of insulin group women was significantly more than metformin group(P=0.05), but there was not any significant difference in cesarean section, preterm labor, dystocia, preeclampsia and still birth rate between two groups. Also neonatal characteristics, need to admission and six-month-old infancy developmental indexes according to Ages stages questionnaire were no different between two groups.
Conclusion: Metformin consumption in compare to insulin was not associated with maternal, neonatal and six-month-old infancy developmental indexes side effects.
Mohammad Azimi Alamouti , Niloufar Shayan, Maryam Momeni, Masoumeh Nouri, Azam Koohkan, Ensiyeh Hajizadeh-Saffar, Fatemeh Soltanolizadeh, Maliheh Mahmoudi, Mahin Jamshidi Makiani, Marzieh Ebrahimi,
Volume 18, Issue 3 (3-2019)
Abstract
Background: For nearly 100 years, amniotic membranes have been used to treat various types of skin wounds. Amniotic extract is one of the derivatives of amniotic membrane that contains all the properties of amniotic membrane. The aim of this study was to evaluate the safety of the amniotic membrane extract in the treatment of diabetic ulcers.
Methods: This study was an Open labeled clinical trial without control group. A total of 10 patients with Wagner Grade 2 diabetic foot ulcers were selected in both sexes. The extract was used every 48 hours in the first week and every 72 hours from the second week until the end of the wound treatment. Patients were followed up weekly until wound healing.
Results: In this study 80% of patients were men and 20% were women with mean age (56.7 ± 8.7) years. The ulcer duration was 8.9 ± 2.12 weeks. The mean area of ulcers at the time of entry into the wound group ≥ 500 mm2, 977.5 ± 201.9 and in the wound group ≤500 mm2 was 145.6 ± 36.4. At 4 weeks post treatment, the wound healing rate in the wound group was ≤500mm2 ,98.9 ± 2.40 % and in the wound group ≥mm2 500 was 92.1 ± 7.23%. in sixth week of treatment, ulcers were complete closure in both groups.
Conclusion: The results of this study suggest that the use of amniotic extract can be effective in the healing of diabetes foot ulcer without any side effects.
Parisa Dana, Nasim Hayati Rodbari, Parichehreh Yaghmaei, Zahra Haj Ebrahimi,
Volume 21, Issue 4 (10-2021)
Abstract
Background: Empagliflozin, selective glucose-sodium inhibitor of the latest drugs in the treatment of type 2 diabetes. Diabetes induced hypogonadism disrupts sexual function. There is a direct relationship between reducing blood glucose and reduced libido. In this project, the anti-diabetic drug Empagliflozin in addition to treatment has been studied, in terms of effect on sexual function.
Methods: Type 2 diabetes with injection of 60 mg/kg streptozotocin per body weight was create intraperitoneally. The primary diabetes was treated with two doses of 10 and 25 mg/kg Empagliflozin per body weight. Sexual hormones, biochemical parameters and lipid profile were measured. Evaluation of Sperm parameters and morphological studies were performed on testicular tissue, pancreas and epididymis. Data were analyzed by one-way ANOVA in SPSS software version 22 and P˂0.05 was considered as a significant level.
Results: Empagliflozin significantly increases the quality, survival and natural state of sperm head and tail. Empagliflozin reduces weight in diabetic rats. Empagliflozin Without increasing hyperglycemia by reducing blood glucose affects steroidogenesis, maintains fertility strength in testicles, and increases the level of sex hormones. Empagliflozin significantly increases insulin secretion. Empagliflozin maintains and integrity of pancreatic beta cells. Empagliflozin has no effect on lipid profile.
Conclusion: Empagliflozin in addition positive effects on the treatment of diabetes in the early stage improves sexual function in adult rats.
Marayam Arabloei Sani, Parichehreh Yaghmaei, Zahra Hajebrahimi, Nasim Hayati Roodbari,
Volume 22, Issue 3 (9-2022)
Abstract
Diabetes is a serious public health problem in low- and middle-income countries. There is a strong association between hyperglycemia, oxidative stress and the development of diabetes. Therefore, screening and early diagnosis of this disease in people at high risk can be effective in preventing these complications. The main route of insulin signaling is to control lipid and glucose metabolism, and its imbalance leads to type 2 diabetes. P-Cymene is an aromatic monoterpene with a wide range of therapeutic properties including antioxidant activity. The aim of this study was to evaluate the effect of p-Cymene at a dose of 50 mg / kg in preventing the symptoms of diabetes and serum factors.
Materials and Methods: 30 male Wistar rats weighing approximately 250 g were randomly selected and divided into five groups: control, diabetic control (sham), metformin-treated diabetic (met), and non-diabetic treated. P-Cymene and diabetics treated with P-Cymene were divided. One week after streptozotocin injection, treatment with P-Cymene at a dose of 50 mg / kg was performed by sunflower oil solvent for 28 days by gavage. At the end of the experiment, blood samples were taken from the hearts of rats and the parameters of glucose, insulin, and superoxide dismutase (SOD) were measured.
Results: The results showed that diabetes increased water and food intake as well as glucose levels and decreased insulin (P <0.001) and superoxide dismutase activity in rats and administration of P-Cymene extract improved the symptoms of diabetes and oxidative stress in Became diabetic rat.
