Showing 2 results for Ebrahimpour
Hossein Fakhrzadeh, Pantea Ebrahimpour, Rasoul Pourebrahim, Ramin Heshmat, Bagher Larijani,
Volume 4, Issue 2 (17 2004)
Abstract
Background: Homocysteine is regarded as a risk factor for metabolic syndrome and cardiovascular diseases. It is of great importance to determine exact risk factors of these disorders because of their high prevalence.
Methods: The 25-64 year old individuals in 17th district of Tehran were studied. It was designed according to the WHO MONICA (Multinational Monitoring of Trends and Determinants in Cardiovascular Disease) project using the ATP III criteria. Homocysteine levels higher than 15 µmol/l and Folate and vitamin B12 lower than 11 nmol/l and 185 pmol/l, respectively were considered as abnormal.
Results: Of the whole population, prevalence of abnormal homocysteine, Folic acid and vitamin B12 was 54.5%, 98.2% and 27%, respectively. Homocysteine levels were higher in men than women (P= 0.026). None of the differences between the means of these three risk factors were statistically significant in people with and without the metabolic syndrome. The only significant difference was higher homocysteine levels in women with metabolic syndrome (P= 0.010).
Conclusions: According to this study, hyperhomocysteinemia and Folate and vitamin B12 deficiency are more prevalent in our population. But there was no correlation between these factors and risk of metabolic syndrome. Because of the controversy about this issue and high prevalence of cardiovascular diseases in our country, further studies are suggested.
Hosein Fakhrzadeh, Pantea Ebrahimpour, Rasool Pourebrahim, Ramin Heshmat, Masoumeh Noori, Alireza Shafaee, Bagher Larijani,
Volume 4, Issue 4 (17 2005)
Abstract
Background: Homocysteine is one of the novel cardiovascular risk factors. We know most of the cardiovascular and diabetes risk factors are accompanied. The aim of this study was to determine the role of homocysteine in diabetes.
Methods: The study was performed in 25-64 year old individuals of the 17th district of Tehran according to WHO MONICA project. Homocysteine levels higher than 15 µmol/l was considered as abnormal. According to ADA 2004 criteria, fasting glucose levels of 100 to 125 mg/dl were considered as impaired glucose tolerance (IGT), while levels higher than 125 mg/dl included diabetes.
Results: Prevalence of hyperhomocysteinemia was 54.5% in the whole population. Prevalence of IGT and diabetes were 3.5% and 10.1%, respectively. There was no difference between prevalence of IGT and diabetes in both hyperhomocysteinemic and normal group (P= 0.365). The difference was also not significant in each genders, but mean glucose levels were significantly lower in people with hyperhomocysteinemia (P= 0.003).
Conclusion: This study emphasizes that an inverse relation between glucose and homocysteine levels. Some studies indicate an opposite result and there is controversy on it. More researches may determine the exact role of homocysteine in diabetes.
